Gene description for FANCI
Gene name Fanconi anemia, complementation group I
Gene symbol FANCI
Other names/aliases KIAA1794
Species Homo sapiens
 Database cross references - FANCI
ExoCarta ExoCarta_55215
Vesiclepedia VP_55215
Entrez Gene 55215
HGNC 25568
MIM 611360
UniProt Q9NVI1  
 FANCI identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for FANCI
Molecular Function
    DNA polymerase binding GO:0070182 IPI
    DNA binding GO:0003677 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of protein ubiquitination GO:0031398 IDA
    cell cycle GO:0007049 IEA
    DNA repair GO:0006281 TAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
    nucleoplasm GO:0005654 TAS
    membrane GO:0016020 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified FANCI in exosomes
1
Experiment ID 217
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|CD81|CD9|CD63
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FANCI
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BRF2  
Affinity Capture-MS Homo sapiens
2 NEK6 10783
Affinity Capture-MS Homo sapiens
3 ILK 3611
Affinity Capture-MS Homo sapiens
4 PTP4A3  
Affinity Capture-MS Homo sapiens
5 MAGED1 9500
Affinity Capture-MS Homo sapiens
6 MYC  
Affinity Capture-MS Homo sapiens
7 PELO 53918
Affinity Capture-MS Homo sapiens
8 C20orf24  
Affinity Capture-MS Homo sapiens
9 GSTK1 373156
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FANCI is involved
PathwayEvidenceSource
Fanconi Anemia pathway TAS Reactome
Regulation of the Fanconi anemia pathway TAS Reactome





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