Gene description for UBL5
Gene name ubiquitin-like 5
Gene symbol UBL5
Other names/aliases HUB1
Species Homo sapiens
 Database cross references - UBL5
ExoCarta ExoCarta_59286
Vesiclepedia VP_59286
Entrez Gene 59286
HGNC 13736
MIM 606849
UniProt Q9BZL1  
 UBL5 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for UBL5
Molecular Function
    protein binding GO:0005515 IPI
    protein tag activity GO:0031386 IBA
Biological Process
    mRNA splicing, via spliceosome GO:0000398 IBA
    protein modification process GO:0036211 IBA
    positive regulation of protein targeting to mitochondrion GO:1903955 HMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    Cajal body GO:0015030 IEA
 Experiment description of studies that identified UBL5 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for UBL5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 PSME2 5721
Two-hybrid Homo sapiens
3 ZNF618  
Two-hybrid Homo sapiens
4 PAX4  
Two-hybrid Homo sapiens
5 KRTAP13-3  
Two-hybrid Homo sapiens
6 UBE2N 7334
Co-fractionation Homo sapiens
7 C1QTNF1 114897
Two-hybrid Homo sapiens
8 MYCN  
Affinity Capture-MS Homo sapiens
9 RBM39 9584
Affinity Capture-MS Homo sapiens
10 HID1 283987
Two-hybrid Homo sapiens
11 HSPB2  
Two-hybrid Homo sapiens
12 NRIP3  
Two-hybrid Homo sapiens
13 COIL  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
14 ZNF124  
Two-hybrid Homo sapiens
15 CCDC28B  
Two-hybrid Homo sapiens
16 ATL3 25923
Affinity Capture-MS Homo sapiens
17 Htatsf1  
Two-hybrid Mus musculus
18 CTAG1A  
Two-hybrid Homo sapiens
19 SPANXB1  
Two-hybrid Homo sapiens
20 TEX35  
Two-hybrid Homo sapiens
21 FAM50B  
Two-hybrid Homo sapiens
22 AES 166
Two-hybrid Homo sapiens
23 NME4 4833
Two-hybrid Homo sapiens
24 CTAG1B  
Two-hybrid Homo sapiens
25 KRTAP10-8  
Two-hybrid Homo sapiens
26 CLK2 1196
Reconstituted Complex Homo sapiens
27 PRMT8  
Two-hybrid Homo sapiens
28 CLK4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
29 Bcas2  
Affinity Capture-MS Mus musculus
30 Nudt21 68219
Two-hybrid Mus musculus
31 SF1 7536
Two-hybrid Homo sapiens
32 TRIM27  
Two-hybrid Homo sapiens
33 DMRTB1  
Two-hybrid Homo sapiens
34 FANCI 55215
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
35 WDR83  
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Two-hybrid Homo sapiens
36 NUP43 348995
Proximity Label-MS Homo sapiens
37 HOXA1 3198
Two-hybrid Homo sapiens
38 TXN 7295
Co-fractionation Homo sapiens
39 SEPT2 4735
Two-hybrid Homo sapiens
40 PINX1  
Two-hybrid Homo sapiens
41 SART1 9092
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
42 CAB39 51719
Co-fractionation Homo sapiens
43 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
44 WAPAL  
Synthetic Lethality Homo sapiens
45 Rbm14  
Two-hybrid Mus musculus
46 Pqbp1  
Affinity Capture-MS Mus musculus
47 PCBP1 5093
Affinity Capture-MS Homo sapiens
48 ZFP41  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
49 AURKA 6790
Affinity Capture-MS Homo sapiens
50 CLK1  
Reconstituted Complex Homo sapiens
51 SMCP  
Two-hybrid Homo sapiens
52 CRKL 1399
Affinity Capture-MS Homo sapiens
53 EGFR 1956
Negative Genetic Homo sapiens
54 SPATC1L  
Two-hybrid Homo sapiens
55 LAP3 51056
Co-fractionation Homo sapiens
56 U2AF2 11338
Affinity Capture-MS Homo sapiens
57 BIN3 55909
Two-hybrid Homo sapiens
58 LENG1  
Two-hybrid Homo sapiens
59 BEND7 222389
Two-hybrid Homo sapiens
60 CERCAM 51148
Two-hybrid Homo sapiens
61 NCOA5  
Two-hybrid Homo sapiens
62 KRAS 3845
Negative Genetic Homo sapiens
63 BMI1  
Affinity Capture-MS Homo sapiens
64 MBD3L1  
Two-hybrid Homo sapiens
65 GCSAML  
Two-hybrid Homo sapiens
66 MYC  
Affinity Capture-MS Homo sapiens
67 DDX58 23586
Affinity Capture-RNA Homo sapiens
68 TRIM39  
Two-hybrid Homo sapiens
69 WASH1 100287171
Two-hybrid Homo sapiens
70 DDX39B 7919
Affinity Capture-MS Homo sapiens
71 LINC00238  
Two-hybrid Homo sapiens
72 SERTAD3  
Two-hybrid Homo sapiens
73 HESX1  
Two-hybrid Homo sapiens
74 ITGA4 3676
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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