Gene description for C1QTNF1
Gene name C1q and tumor necrosis factor related protein 1
Gene symbol C1QTNF1
Other names/aliases CTRP1
GIP
ZSIG37
Species Homo sapiens
 Database cross references - C1QTNF1
ExoCarta ExoCarta_114897
Entrez Gene 114897
HGNC 14324
MIM 610365
UniProt Q9BXJ1  
 C1QTNF1 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for C1QTNF1
Molecular Function
    protein binding GO:0005515 IPI
    collagen binding GO:0005518 IDA
Biological Process
    protein homooligomerization GO:0051260 IEA
    protein heterotrimerization GO:0070208 IEA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IDA
    negative regulation of platelet aggregation GO:0090331 IDA
    positive regulation of MAPK cascade GO:0043410 IEA
    positive regulation of gene expression GO:0010628 IDA
    positive regulation of aldosterone secretion GO:2000860 IDA
    regulation of glucose metabolic process GO:0010906 IEA
    positive regulation of protein kinase B signaling GO:0051897 IEA
    negative regulation of platelet activation GO:0010544 IDA
Subcellular Localization
    collagen trimer GO:0005581 IEA
    extracellular space GO:0005615 IDA
    integral component of plasma membrane GO:0005887 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified C1QTNF1 in exosomes
1
Experiment ID 66
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for C1QTNF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SGTA 6449
Two-hybrid Homo sapiens
2 AVPR2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which C1QTNF1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here