Gene description for KIF7
Gene name kinesin family member 7
Gene symbol KIF7
Other names/aliases ACLS
HLS2
JBTS12
UNQ340
Species Homo sapiens
 Database cross references - KIF7
ExoCarta ExoCarta_374654
Vesiclepedia VP_374654
Entrez Gene 374654
HGNC 30497
MIM 611254
UniProt Q2M1P5  
 KIF7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for KIF7
Molecular Function
    microtubule motor activity GO:0003777 IBA
    microtubule motor activity GO:0003777 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    microtubule binding GO:0008017 IBA
    ATP hydrolysis activity GO:0016887 IBA
Biological Process
    microtubule-based movement GO:0007018 IBA
    negative regulation of smoothened signaling pathway GO:0045879 ISS
    positive regulation of smoothened signaling pathway GO:0045880 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    kinesin complex GO:0005871 IBA
    microtubule GO:0005874 IBA
    cilium GO:0005929 IDA
    ciliary basal body GO:0036064 ISS
    ciliary tip GO:0097542 TAS
 Experiment description of studies that identified KIF7 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for KIF7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 NUF2  
Affinity Capture-MS Homo sapiens
3 PTPN22  
Proximity Label-MS Homo sapiens
4 SEPT10 151011
Proximity Label-MS Homo sapiens
5 TPTE2  
Proximity Label-MS Homo sapiens
6 P4HA2 8974
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 NUP62 23636
Affinity Capture-MS Homo sapiens
8 TRIM66  
Affinity Capture-MS Homo sapiens
9 APC  
Affinity Capture-MS Homo sapiens
10 TNFAIP6 7130
Affinity Capture-MS Homo sapiens
11 STX11 8676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 NDC80 10403
Proximity Label-MS Homo sapiens
14 C11orf30  
Affinity Capture-MS Homo sapiens
15 TBC1D31  
Affinity Capture-MS Homo sapiens
16 CAPN12  
Affinity Capture-MS Homo sapiens
17 ZNF74  
Affinity Capture-MS Homo sapiens
18 CCDC14  
Proximity Label-MS Homo sapiens
19 SMTN 6525
Affinity Capture-MS Homo sapiens
20 IMPDH2 3615
Proximity Label-MS Homo sapiens
21 ZNF460  
Affinity Capture-MS Homo sapiens
22 BRPF3  
Affinity Capture-MS Homo sapiens
23 YWHAG 7532
Affinity Capture-MS Homo sapiens
24 PHLDB2 90102
Affinity Capture-MS Homo sapiens
25 DGCR2 9993
Affinity Capture-MS Homo sapiens
26 CCDC18  
Affinity Capture-MS Homo sapiens
27 YWHAH 7533
Affinity Capture-MS Homo sapiens
28 POLR2C 5432
Proximity Label-MS Homo sapiens
29 CEP131 22994
Affinity Capture-MS Homo sapiens
30 MAD2L1 4085
Affinity Capture-MS Homo sapiens
31 RBM14 10432
Affinity Capture-MS Homo sapiens
32 CINP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 NINL  
Proximity Label-MS Homo sapiens
34 USP22 23326
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 NUP155 9631
Proximity Label-MS Homo sapiens
36 PFN1 5216
Proximity Label-MS Homo sapiens
37 EPB41L3 23136
Affinity Capture-MS Homo sapiens
38 KRT8 3856
Proximity Label-MS Homo sapiens
39 TAF8  
Affinity Capture-MS Homo sapiens
40 PRPH 5630
Proximity Label-MS Homo sapiens
41 PIBF1  
Affinity Capture-MS Homo sapiens
42 IMPACT 55364
Affinity Capture-MS Homo sapiens
43 CEP72  
Affinity Capture-MS Homo sapiens
44 PARD3 56288
Proximity Label-MS Homo sapiens
45 ACTL6A 86
Affinity Capture-MS Homo sapiens
46 GLI3 2737
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 PNMA2  
Affinity Capture-MS Homo sapiens
48 DCTN1 1639
Proximity Label-MS Homo sapiens
49 BICD2 23299
Proximity Label-MS Homo sapiens
50 STIL  
Proximity Label-MS Homo sapiens
51 BBS4 585
Affinity Capture-MS Homo sapiens
52 CCDC61  
Affinity Capture-MS Homo sapiens
53 GMPS 8833
Affinity Capture-MS Homo sapiens
54 DYNLRB2 83657
Affinity Capture-MS Homo sapiens
55 SSX2IP  
Affinity Capture-MS Homo sapiens
56 DISC1 27185
Affinity Capture-MS Homo sapiens
57 CEP135  
Proximity Label-MS Homo sapiens
58 USP15 9958
Affinity Capture-MS Homo sapiens
59 NR3C1 2908
Proximity Label-MS Homo sapiens
60 GLI1  
Affinity Capture-MS Homo sapiens
61 SASS6 163786
Proximity Label-MS Homo sapiens
62 LZTS2 84445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 MAPRE3  
Proximity Label-MS Homo sapiens
64 CCDC77  
Affinity Capture-MS Homo sapiens
65 NEFM 4741
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 NIN 51199
Proximity Label-MS Homo sapiens
67 C1QTNF1 114897
Affinity Capture-MS Homo sapiens
68 SAV1  
Proximity Label-MS Homo sapiens
69 MPZL1 9019
Affinity Capture-MS Homo sapiens
70 MAP3K4 4216
Affinity Capture-MS Homo sapiens
71 RAB11FIP2  
Affinity Capture-MS Homo sapiens
72 N4BP3  
Affinity Capture-MS Homo sapiens
73 DLL1  
Affinity Capture-MS Homo sapiens
74 BICD1 636
Proximity Label-MS Homo sapiens
75 FLII 2314
Affinity Capture-MS Homo sapiens
76 SLC39A10 57181
Affinity Capture-MS Homo sapiens
77 PCM1 5108
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 AMOT  
Proximity Label-MS Homo sapiens
79 RAB28 9364
Affinity Capture-MS Homo sapiens
80 KRT19 3880
Proximity Label-MS Homo sapiens
81 PPFIA1 8500
Affinity Capture-MS Homo sapiens
82 DOCK6 57572
Affinity Capture-MS Homo sapiens
83 KRT16 3868
Affinity Capture-MS Homo sapiens
84 ZNF263  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 CCDC8  
Affinity Capture-MS Homo sapiens
86 RBBP8  
Affinity Capture-MS Homo sapiens
87 ZRANB1 54764
Affinity Capture-MS Homo sapiens
88 KRT18 3875
Proximity Label-MS Homo sapiens
89 RALBP1 10928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
91 ZNF785  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 LRRCC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 STAMBP 10617
Affinity Capture-MS Homo sapiens
94 SQSTM1 8878
Proximity Label-MS Homo sapiens
95 FAM184A 79632
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
96 LATS1  
Proximity Label-MS Homo sapiens
97 FGL2 10875
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 ANAPC2 29882
Proximity Label-MS Homo sapiens
99 KRT38 8687
Affinity Capture-MS Homo sapiens
100 GLI2  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 PXN 5829
Proximity Label-MS Homo sapiens
102 ZUFSP 221302
Affinity Capture-MS Homo sapiens
103 HSPG2 3339
Affinity Capture-MS Homo sapiens
104 ZNF331  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 LURAP1  
Affinity Capture-MS Homo sapiens
106 NRD1 4898
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KIF7 is involved
PathwayEvidenceSource
Hedgehog 'off' state TAS Reactome
Hedgehog 'on' state TAS Reactome
Signal Transduction TAS Reactome
Signaling by Hedgehog TAS Reactome





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