Gene description for BICD1
Gene name bicaudal D homolog 1 (Drosophila)
Gene symbol BICD1
Other names/aliases BICD
Species Homo sapiens
 Database cross references - BICD1
ExoCarta ExoCarta_636
Entrez Gene 636
HGNC 1049
MIM 602204
UniProt Q96G01  
 BICD1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for BICD1
Molecular Function
    dynein binding GO:0045502 IDA
    cytoskeletal adaptor activity GO:0008093 IDA
    structural constituent of cytoskeleton GO:0005200 TAS
    Rab GTPase binding GO:0017137 IPI
    proteinase activated receptor binding GO:0031871 ISS
    dynactin binding GO:0034452 IDA
    protein binding GO:0005515 IPI
Biological Process
    protein localization to organelle GO:0033365 IDA
    regulation of proteinase activated receptor activity GO:1900276 ISS
    negative regulation of phospholipase C activity GO:1900275 ISS
    positive regulation of receptor-mediated endocytosis GO:0048260 IMP
    RNA processing GO:0006396 TAS
    negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway GO:1900737 ISS
    anatomical structure morphogenesis GO:0009653 TAS
    microtubule anchoring at microtubule organizing center GO:0072393 ISS
    intracellular mRNA localization GO:0008298 NAS
    minus-end-directed organelle transport along microtubule GO:0072385 IMP
    stress granule assembly GO:0034063 ISS
    viral process GO:0016032 IMP
Subcellular Localization
    cytoskeleton GO:0005856 NAS
    perinuclear region of cytoplasm GO:0048471 IDA
    Golgi apparatus GO:0005794 IDA
    host cell viral assembly compartment GO:0072517 IDA
    cytoplasmic microtubule GO:0005881 IDA
    trans-Golgi network GO:0005802 IDA
    tubulin complex GO:0045298 TAS
    cytoplasmic vesicle GO:0031410 IDA
    membrane GO:0016020 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified BICD1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for BICD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAB6A 5870
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which BICD1 is involved
No pathways found





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