Gene description for NFATC3
Gene name nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
Gene symbol NFATC3
Other names/aliases NFAT4
NFATX
Species Homo sapiens
 Database cross references - NFATC3
ExoCarta ExoCarta_4775
Entrez Gene 4775
HGNC 7777
MIM 602698
UniProt Q12968  
 NFATC3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for NFATC3
Molecular Function
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IMP
    protein binding GO:0005515 IPI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    chromatin binding GO:0003682 IEA
Biological Process
    inflammatory response GO:0006954 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS
    innate immune response GO:0045087 TAS
    smooth muscle cell differentiation GO:0051145 IEA
    muscle cell development GO:0055001 IEA
    heart development GO:0007507 IEA
    cellular respiration GO:0045333 IEA
    cellular response to lithium ion GO:0071285 IEA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    patterning of blood vessels GO:0001569 IEA
    transcription from RNA polymerase II promoter GO:0006366 TAS
    cellular response to calcium ion GO:0071277 IEA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    nucleus GO:0005634 IDA
    nucleolus GO:0005730 IDA
 Experiment description of studies that identified NFATC3 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for NFATC3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which NFATC3 is involved
PathwayEvidenceSource
CLEC7A (Dectin-1) induces NFAT activation TAS Reactome
FCERI mediated Ca+2 mobilization TAS Reactome





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