Gene description for ZMIZ1
Gene name zinc finger, MIZ-type containing 1
Gene symbol ZMIZ1
Other names/aliases MIZ
RAI17
TRAFIP10
ZIMP10
hZIMP10
Species Homo sapiens
 Database cross references - ZMIZ1
ExoCarta ExoCarta_57178
Vesiclepedia VP_57178
Entrez Gene 57178
HGNC 16493
MIM 607159
UniProt Q9ULJ6  
 ZMIZ1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ZMIZ1
Molecular Function
    transcription coactivator activity GO:0003713 IDA
    zinc ion binding GO:0008270 IEA
    nuclear receptor coactivator activity GO:0030374 IBA
    SMAD binding GO:0046332 IPI
    SUMO ligase activity GO:0061665 IBA
Biological Process
    vasculogenesis GO:0001570 IEA
    in utero embryonic development GO:0001701 IEA
    heart morphogenesis GO:0003007 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    vitellogenesis GO:0007296 IEA
    protein sumoylation GO:0016925 IBA
    pyramidal neuron migration to cerebral cortex GO:0021852 IMP
    androgen receptor signaling pathway GO:0030521 IDA
    positive regulation of T cell differentiation GO:0045582 ISS
    positive regulation of Notch signaling pathway GO:0045747 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of fibroblast proliferation GO:0048146 IEA
    developmental growth GO:0048589 IEA
    artery morphogenesis GO:0048844 IEA
    SMAD protein signal transduction GO:0060395 IDA
    cellular senescence GO:0090398 IEA
Subcellular Localization
    chromatin GO:0000785 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified ZMIZ1 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ZMIZ1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BCLAF1 9774
Affinity Capture-MS Homo sapiens
2 HNRNPD 3184
Affinity Capture-MS Homo sapiens
3 SETD4 54093
Co-fractionation Homo sapiens
4 RBPJ 3516
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
5 TP53 7157
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
6 ZEB1  
Affinity Capture-MS Homo sapiens
7 CTNNB1 1499
Affinity Capture-MS Homo sapiens
8 MAML1  
Affinity Capture-MS Homo sapiens
9 BRCA1 672
Affinity Capture-MS Homo sapiens
10 SMAD4  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
11 PIAS3  
Two-hybrid Homo sapiens
12 NUP35 129401
Proximity Label-MS Homo sapiens
13 DDX58 23586
Affinity Capture-RNA Homo sapiens
14 TBR1  
Proximity Label-MS Homo sapiens
15 CCR7  
Affinity Capture-MS Homo sapiens
16 CNTNAP2  
Two-hybrid Homo sapiens
17 TRIM28 10155
Affinity Capture-MS Homo sapiens
18 ETV4  
Proximity Label-MS Homo sapiens
19 SMAD3 4088
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
20 ETS1  
Affinity Capture-Western Homo sapiens
21 TCF7  
Affinity Capture-MS Homo sapiens
22 AR 367
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
23 NFATC3 4775
Affinity Capture-MS Homo sapiens
24 SIRT1  
Affinity Capture-MS Homo sapiens
25 NANOG  
Affinity Capture-MS Homo sapiens
26 SP7  
Proximity Label-MS Homo sapiens
27 NOTCH1 4851
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
28 SATB1 6304
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZMIZ1 is involved
No pathways found





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