Gene description for SETD4
Gene name SET domain containing 4
Gene symbol SETD4
Other names/aliases C21orf18
C21orf27
Species Homo sapiens
 Database cross references - SETD4
ExoCarta ExoCarta_54093
Vesiclepedia VP_54093
Entrez Gene 54093
HGNC 1258
UniProt Q9NVD3  
 SETD4 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 19837982    
 Gene ontology annotations for SETD4
Molecular Function
    transcription coactivator activity GO:0003713 IBA
    protein binding GO:0005515 IPI
    histone H4K20 methyltransferase activity GO:0042799 IDA
    histone H3K4 methyltransferase activity GO:0042800 IBA
    histone H3K4 methyltransferase activity GO:0042800 ISS
    histone H3K36 methyltransferase activity GO:0046975 IBA
    histone H4K20me methyltransferase activity GO:0140941 IEA
    histone H4K20 monomethyltransferase activity GO:0140944 IEA
    histone H3K4 monomethyltransferase activity GO:0140945 IEA
Biological Process
    chromatin remodeling GO:0006338 IBA
    chromatin remodeling GO:0006338 ISS
    inflammatory response GO:0006954 IEA
    methylation GO:0032259 IEA
    positive regulation of interleukin-6 production GO:0032755 ISS
    positive regulation of tumor necrosis factor production GO:0032760 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of inflammatory response GO:0050729 IBA
    positive regulation of inflammatory response GO:0050729 ISS
    regulation of cell proliferation in bone marrow GO:0071863 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified SETD4 in sEVs
1
Experiment ID 21
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors "Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson"
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for SETD4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GDF15 9518
Affinity Capture-MS Homo sapiens
2 GBE1 2632
Affinity Capture-MS Homo sapiens
3 NXF1 10482
Affinity Capture-RNA Homo sapiens
4 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
5 RPL37A 6168
Affinity Capture-MS Homo sapiens
6 FAM96A  
Two-hybrid Homo sapiens
7 MRPL1  
Co-fractionation Homo sapiens
8 RPL36 25873
Affinity Capture-MS Homo sapiens
9 IMPDH1 3614
Affinity Capture-MS Homo sapiens
10 CORO7 79585
Affinity Capture-MS Homo sapiens
11 ZMIZ1 57178
Co-fractionation Homo sapiens
12 WWP1 11059
Affinity Capture-MS Homo sapiens
13 USP11 8237
Affinity Capture-MS Homo sapiens
14 TP53 7157
Negative Genetic Homo sapiens
15 PMM2 5373
Affinity Capture-MS Homo sapiens
16 DDX55  
Co-fractionation Homo sapiens
17 LRRC59 55379
Affinity Capture-MS Homo sapiens
18 TCEAL1  
Affinity Capture-MS Homo sapiens
19 LGALS7 3963
Affinity Capture-MS Homo sapiens
20 TADA3  
Affinity Capture-MS Homo sapiens
21 SNRPD2 6633
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SETD4 is involved
No pathways found





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