Gene description for MAPK8
Gene name mitogen-activated protein kinase 8
Gene symbol MAPK8
Other names/aliases JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
Species Homo sapiens
 Database cross references - MAPK8
ExoCarta ExoCarta_5599
Vesiclepedia VP_5599
Entrez Gene 5599
HGNC 6881
MIM 601158
UniProt P45983  
 MAPK8 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for MAPK8
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 TAS
    JUN kinase activity GO:0004705 IBA
    JUN kinase activity GO:0004705 IDA
    JUN kinase activity GO:0004705 ISS
    JUN kinase activity GO:0004705 TAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    enzyme binding GO:0019899 IPI
    protein phosphatase binding GO:0019903 IPI
    histone deacetylase regulator activity GO:0035033 IMP
    histone deacetylase binding GO:0042826 IPI
    protein serine kinase activity GO:0106310 IEA
    protein serine/threonine kinase binding GO:0120283 IPI
Biological Process
    protein phosphorylation GO:0006468 IMP
    response to oxidative stress GO:0006979 IDA
    JNK cascade GO:0007254 IBA
    JNK cascade GO:0007254 IDA
    JUN phosphorylation GO:0007258 IDA
    JUN phosphorylation GO:0007258 IDA
    response to UV GO:0009411 IDA
    response to mechanical stimulus GO:0009612 IBA
    positive regulation of gene expression GO:0010628 IMP
    regulation of macroautophagy GO:0016241 TAS
    peptidyl-serine phosphorylation GO:0018105 IDA
    peptidyl-threonine phosphorylation GO:0018107 IDA
    positive regulation of cyclase activity GO:0031281 IMP
    positive regulation of cell killing GO:0031343 TAS
    negative regulation of protein binding GO:0032091 IDA
    regulation of protein localization GO:0032880 IDA
    cellular response to amino acid starvation GO:0034198 IDA
    cellular response to oxidative stress GO:0034599 IDA
    cellular response to reactive oxygen species GO:0034614 IDA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    regulation of circadian rhythm GO:0042752 ISS
    positive regulation of apoptotic process GO:0043065 IBA
    positive regulation of apoptotic process GO:0043065 TAS
    negative regulation of apoptotic process GO:0043066 IDA
    negative regulation of apoptotic process GO:0043066 IDA
    rhythmic process GO:0048511 IEA
    positive regulation of protein metabolic process GO:0051247 IMP
    stress-activated MAPK cascade GO:0051403 IDA
    cellular response to lipopolysaccharide GO:0071222 IDA
    cellular response to mechanical stimulus GO:0071260 IEP
    cellular senescence GO:0090398 TAS
    energy homeostasis GO:0097009 ISS
    positive regulation of NLRP3 inflammasome complex assembly GO:1900227 IDA
    positive regulation of establishment of protein localization to mitochondrion GO:1903749 TAS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 TAS
    axon GO:0030424 ISS
    synapse GO:0045202 ISS
    basal dendrite GO:0097441 ISS
 Experiment description of studies that identified MAPK8 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MAPK8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSTP1 2950
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
2 ZNF605  
Two-hybrid Homo sapiens
3 CRTC3  
Affinity Capture-MS Homo sapiens
4 CCT3 7203
Affinity Capture-MS Homo sapiens
5 LAMP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
7 ATE1 11101
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 DUSP8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SP1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
10 CRK 1398
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
11 MKNK2 2872
Two-hybrid Homo sapiens
12 PAX2  
Biochemical Activity Homo sapiens
13 JUND 3727
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
14 CASP10  
Co-purification Homo sapiens
15 CCT4 10575
Affinity Capture-MS Homo sapiens
16 ATM 472
Biochemical Activity Homo sapiens
17 COG2 22796
Affinity Capture-MS Homo sapiens
18 PRKDC 5591
Biochemical Activity Homo sapiens
19 APP 351
Reconstituted Complex Homo sapiens
20 ARHGDIA 396
Co-purification Homo sapiens
21 HIST2H2AA3 8337
Affinity Capture-MS Homo sapiens
22 SPANXN4  
Affinity Capture-MS Homo sapiens
23 WDR62  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 VANGL2  
Affinity Capture-Western Homo sapiens
25 TKT 7086
Affinity Capture-MS Homo sapiens
26 JUNB  
Affinity Capture-Western Homo sapiens
27 SH3BP5 9467
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
28 JKAMP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
29 MAP3K7  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
30 GFPT1 2673
Two-hybrid Homo sapiens
31 CASP3 836
Biochemical Activity Homo sapiens
32 APBB2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
33 RFXANK  
Affinity Capture-MS Homo sapiens
34 CCDC88C 440193
Two-hybrid Homo sapiens
35 SPAG9 9043
Affinity Capture-Western Homo sapiens
36 FZR1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
37 NFE2L2 4780
Affinity Capture-Western Homo sapiens
38 STAT3 6774
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
39 NCOA3  
Biochemical Activity Homo sapiens
40 STK11IP 114790
Affinity Capture-MS Homo sapiens
41 MAPK14 1432
Affinity Capture-Western Homo sapiens
42 FAM193B 54540
Two-hybrid Homo sapiens
43 MAPK8IP1 9479
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
44 RHOA 387
Co-purification Homo sapiens
Co-localization Homo sapiens
45 BAX 581
Affinity Capture-Western Homo sapiens
46 C2orf44  
Affinity Capture-MS Homo sapiens
47 SUN2 25777
Affinity Capture-MS Homo sapiens
48 HRAS 3265
Phenotypic Suppression Homo sapiens
49 ZNF219  
Two-hybrid Homo sapiens
50 NFATC3 4775
Two-hybrid Homo sapiens
51 HSD17B4 3295
Two-hybrid Homo sapiens
52 GPS1 2873
Phenotypic Suppression Homo sapiens
53 HSPA8 3312
Two-hybrid Homo sapiens
54 FAS 355
Co-purification Homo sapiens
Co-localization Homo sapiens
55 CCT2 10576
Affinity Capture-MS Homo sapiens
56 GARS 2617
Two-hybrid Homo sapiens
57 PPM1B 5495
Co-fractionation Homo sapiens
58 KRT8 3856
Affinity Capture-Western Homo sapiens
59 MAPK8IP3  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
60 CAMP 820
Two-hybrid Homo sapiens
61 FAM96A  
Affinity Capture-MS Homo sapiens
62 BCAR1 9564
Affinity Capture-Western Homo sapiens
63 TCP1 6950
Affinity Capture-MS Homo sapiens
64 FASLG 356
Co-purification Homo sapiens
Co-localization Homo sapiens
65 PLBD1 79887
Affinity Capture-MS Homo sapiens
66 MAP3K2 10746
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
67 BCL2L11  
Biochemical Activity Homo sapiens
68 CDKN1A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
69 PARK2  
Affinity Capture-MS Homo sapiens
70 PNRC1 10957
Two-hybrid Homo sapiens
71 HIVEP1 3096
Two-hybrid Homo sapiens
72 SCAND1  
Two-hybrid Homo sapiens
73 CBL 867
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
74 ATF2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
75 STAB2 55576
Affinity Capture-Western Homo sapiens
76 RPS6KB1 6198
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
77 PSMD2 5708
Affinity Capture-MS Homo sapiens
78 CTSC 1075
Affinity Capture-MS Homo sapiens
79 MBP 4155
Biochemical Activity Homo sapiens
80 REL 5966
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
81 PIAS2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
82 RAD18  
Biochemical Activity Homo sapiens
83 Trp53  
Biochemical Activity Mus musculus
84 FLNB 2317
Affinity Capture-Western Homo sapiens
85 BAK1 578
Affinity Capture-Western Homo sapiens
86 GANAB 23193
Two-hybrid Homo sapiens
87 SCOC 60592
Two-hybrid Homo sapiens
88 MAPK8 5599
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
89 ITCH 83737
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
90 AIMP1 9255
Biochemical Activity Homo sapiens
91 CEBPA  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
92 NFATC4 4776
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
93 USP32 84669
Affinity Capture-MS Homo sapiens
94 MAP2K7 5609
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Phenotypic Enhancement Homo sapiens
Protein-peptide Homo sapiens
Co-localization Homo sapiens
95 PSG11  
Affinity Capture-MS Homo sapiens
96 MAP2K1 5604
Protein-peptide Homo sapiens
97 PHLPP1  
Affinity Capture-MS Homo sapiens
98 PKMYT1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
99 DUSP1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
100 SPIB  
Co-purification Homo sapiens
Biochemical Activity Homo sapiens
101 ID2  
Two-hybrid Homo sapiens
102 RPLP2 6181
Two-hybrid Homo sapiens
103 NR4A1  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
104 C11orf57  
Two-hybrid Homo sapiens
105 PITRM1 10531
Co-fractionation Homo sapiens
106 YWHAZ 7534
Biochemical Activity Homo sapiens
107 ELK4 2005
Biochemical Activity Homo sapiens
108 AKT1 207
Biochemical Activity Homo sapiens
109 CCT6A 908
Affinity Capture-MS Homo sapiens
110 GORASP2 26003
Biochemical Activity Homo sapiens
111 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
112 ETV1  
Biochemical Activity Homo sapiens
113 HDAC9  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
114 SH3RF3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
115 TNFRSF1A 7132
Co-purification Homo sapiens
116 SF1 7536
Affinity Capture-MS Homo sapiens
117 DCP1A 55802
Co-localization Homo sapiens
118 PRKD1 5587
Affinity Capture-Western Homo sapiens
119 EGFR 1956
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
120 MAP3K1 4214
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
121 PHKG2 5261
Affinity Capture-MS Homo sapiens
122 METTL21B  
Affinity Capture-MS Homo sapiens
123 PDPK1 5170
Reconstituted Complex Homo sapiens
124 DUSP16  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
125 TFCP2 7024
Biochemical Activity Homo sapiens
126 CDC42 998
Co-localization Homo sapiens
127 CCDC50 152137
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
128 JUN 3725
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
129 ELK1  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
130 PRR3  
Affinity Capture-MS Homo sapiens
131 TJP2 9414
Affinity Capture-MS Homo sapiens
132 C3orf18  
Affinity Capture-MS Homo sapiens
133 MYC  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
134 MTOR 2475
Affinity Capture-Western Homo sapiens
135 CCT8 10694
Affinity Capture-MS Homo sapiens
136 MAP3K4 4216
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
137 BLMH 642
Affinity Capture-MS Homo sapiens
138 BCL2L1 598
Co-localization Homo sapiens
139 VRK2 7444
Affinity Capture-Western Homo sapiens
140 RAF1 5894
Two-hybrid Homo sapiens
141 PRKY  
Affinity Capture-MS Homo sapiens
142 MSN 4478
Co-purification Homo sapiens
143 CDKN1B 1027
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
144 NFATC2  
Affinity Capture-Western Homo sapiens
145 IRF3 3661
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
146 H2AFX 3014
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
147 Rara  
Biochemical Activity Mus musculus
148 C6orf222  
Affinity Capture-MS Homo sapiens
149 FERMT1 55612
Co-fractionation Homo sapiens
150 IKBKAP 8518
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
151 SNCA 6622
Affinity Capture-Western Homo sapiens
152 MAP2K2 5605
Protein-peptide Homo sapiens
153 FADD 8772
Co-purification Homo sapiens
154 BMF  
Biochemical Activity Homo sapiens
155 MAPKAP1 79109
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
156 TRAF2 7186
Affinity Capture-Western Homo sapiens
157 MAP2K4 6416
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Phenotypic Enhancement Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
158 DUSP10 11221
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
159 Rps6kb1  
Reconstituted Complex Mus musculus
160 ALDH9A1 223
Co-fractionation Homo sapiens
161 BAD  
Co-localization Homo sapiens
162 TP53 7157
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
163 NFE2  
Biochemical Activity Homo sapiens
164 BCL7A  
Affinity Capture-MS Homo sapiens
165 SSU72 29101
Two-hybrid Homo sapiens
166 SH2D3A  
Phenotypic Enhancement Homo sapiens
167 EZR 7430
Co-purification Homo sapiens
168 SNCG 6623
Affinity Capture-Western Homo sapiens
169 CASP8 841
Co-purification Homo sapiens
170 RPTOR 57521
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
171 BID  
Co-purification Homo sapiens
172 HDAC1 3065
Affinity Capture-Western Homo sapiens
173 RBM15 64783
Two-hybrid Homo sapiens
174 TAF1D  
Affinity Capture-MS Homo sapiens
175 SIRT1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
176 NUP98 4928
Affinity Capture-MS Homo sapiens
177 Dusp22  
Affinity Capture-Western Mus musculus
178 GSTM3 2947
Affinity Capture-MS Homo sapiens
179 RABL3 285282
Affinity Capture-MS Homo sapiens
180 TNFRSF10B 8795
Co-purification Homo sapiens
181 FAM110D  
Affinity Capture-MS Homo sapiens
182 BCL2  
Biochemical Activity Homo sapiens
183 MAPK9 5601
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
184 HSF1  
Reconstituted Complex Homo sapiens
185 PXN 5829
Co-localization Homo sapiens
186 METTL3  
Biochemical Activity Homo sapiens
187 DUSP4 1846
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
188 SMAD3 4088
Co-localization Homo sapiens
189 BMPR2 659
Two-hybrid Homo sapiens
190 UBXN6 80700
Affinity Capture-MS Homo sapiens
191 ANXA7 310
Affinity Capture-MS Homo sapiens
192 SPI1  
Biochemical Activity Homo sapiens
193 IRS1 3667
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
194 GUCY1A3  
Two-hybrid Homo sapiens
195 GPS2  
Phenotypic Suppression Homo sapiens
196 Dusp9  
Two-hybrid Mus musculus
197 EP300 2033
Biochemical Activity Homo sapiens
198 KCNAB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MAPK8 is involved
PathwayEvidenceSource
Activation of BH3-only proteins TAS Reactome
Activation of BIM and translocation to mitochondria TAS Reactome
Activation of BMF and translocation to mitochondria TAS Reactome
Activation of the AP-1 family of transcription factors TAS Reactome
Apoptosis TAS Reactome
Cell death signalling via NRAGE, NRIF and NADE TAS Reactome
Cell death signalling via NRAGE, NRIF and NADE IEA Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Death Receptor Signaling TAS Reactome
Death Receptor Signaling IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
DNA Double Strand Break Response TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA Repair TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
FCERI mediated MAPK activation TAS Reactome
Immune System TAS Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Interleukin-1 family signaling TAS Reactome
Interleukin-17 signaling TAS Reactome
Interleukin-38 signaling TAS Reactome
Intrinsic Pathway for Apoptosis TAS Reactome
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TAS Reactome
Killing mechanisms TAS Reactome
Leishmania infection TAS Reactome
MAP kinase activation TAS Reactome
MAPK targets/ Nuclear events mediated by MAP kinases TAS Reactome
MyD88 cascade initiated on plasma membrane TAS Reactome
MyD88 dependent cascade initiated on endosome TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
NRAGE signals death through JNK TAS Reactome
NRAGE signals death through JNK IEA Reactome
NRIF signals cell death from the nucleus IEA Reactome
Oxidative Stress Induced Senescence TAS Reactome
p75 NTR receptor-mediated signalling TAS Reactome
p75 NTR receptor-mediated signalling IEA Reactome
Parasitic Infection Pathways TAS Reactome
Programmed Cell Death TAS Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by ALK fusions and activated point mutants TAS Reactome
Signaling by ALK in cancer TAS Reactome
Signaling by Interleukins TAS Reactome
Toll Like Receptor 10 (TLR10) Cascade TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor 5 (TLR5) Cascade TAS Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade TAS Reactome
Toll Like Receptor 9 (TLR9) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
WNT5:FZD7-mediated leishmania damping TAS Reactome





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