Gene description for MAP2K4
Gene name	mitogen-activated protein kinase kinase 4
Gene symbol	MAP2K4
Other names/aliases	JNKK JNKK1 MAPKK4 MEK4 MKK4 PRKMK4 SAPKK-1 SAPKK1 SEK1 SERK1 SKK1
Species	Homo sapiens
Database cross references - MAP2K4
ExoCarta	ExoCarta_6416
Entrez Gene	6416
HGNC	6844
MIM	601335
UniProt	P45985
MAP2K4 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Thymus	23844026

Gene ontology annotations for MAP2K4

Molecular Function     mitogen-activated protein kinase kinase kinase binding GO:0031435 IEA     protein serine/threonine kinase activity GO:0004674 IEA     ATP binding GO:0005524 IEA     JUN kinase kinase activity GO:0008545 IBA     protein tyrosine kinase activity GO:0004713 IEA     protein binding GO:0005515 IPI     protein kinase activity GO:0004672 TAS Biological Process     toll-like receptor 2 signaling pathway GO:0034134 TAS     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     JNK cascade GO:0007254 TAS     positive regulation of neuron apoptotic process GO:0043525 IEA     stress-activated MAPK cascade GO:0051403 TAS     cellular response to mechanical stimulus GO:0071260 IEP     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     innate immune response GO:0045087 TAS     cellular response to sorbitol GO:0072709 IEA     toll-like receptor 5 signaling pathway GO:0034146 TAS     toll-like receptor 4 signaling pathway GO:0034142 TAS     peptidyl-tyrosine phosphorylation GO:0018108 IEA     positive regulation of DNA replication GO:0045740 IEA     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     signal transduction GO:0007165 TAS     toll-like receptor signaling pathway GO:0002224 TAS     cell growth involved in cardiac muscle cell development GO:0061049 IEA     positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 IEA     apoptotic process GO:0006915 IEA     activation of JUN kinase activity GO:0007257 IBA     Fc-epsilon receptor signaling pathway GO:0038095 TAS     toll-like receptor 9 signaling pathway GO:0034162 TAS     toll-like receptor 3 signaling pathway GO:0034138 TAS     toll-like receptor 10 signaling pathway GO:0034166 TAS Subcellular Localization     intracellular GO:0005622 IBA     axon GO:0030424 IEA     cytosol GO:0005829 TAS     dendrite cytoplasm GO:0032839 IEA     nucleus GO:0005634 IEA     perikaryon GO:0043204 IEA