Gene description for MAPK14
Gene name mitogen-activated protein kinase 14
Gene symbol MAPK14
Other names/aliases CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
Species Homo sapiens
 Database cross references - MAPK14
ExoCarta ExoCarta_1432
Vesiclepedia VP_1432
Entrez Gene 1432
HGNC 6876
MIM 600289
UniProt Q16539  
 MAPK14 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for MAPK14
Molecular Function
    protein serine/threonine kinase activity GO:0004674 EXP
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 TAS
    JUN kinase activity GO:0004705 IEA
    MAP kinase activity GO:0004707 IDA
    MAP kinase kinase activity GO:0004708 TAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    enzyme binding GO:0019899 IPI
    protein phosphatase binding GO:0019903 IPI
    mitogen-activated protein kinase p38 binding GO:0048273 IPI
    NFAT protein binding GO:0051525 ISS
    protein serine kinase activity GO:0106310 IEA
Biological Process
    DNA damage checkpoint signaling GO:0000077 IEA
    cell morphogenesis GO:0000902 IEA
    cartilage condensation GO:0001502 IEA
    angiogenesis GO:0001525 IEA
    osteoblast differentiation GO:0001649 IEA
    placenta development GO:0001890 IEA
    response to dietary excess GO:0002021 IEA
    chondrocyte differentiation GO:0002062 IEA
    negative regulation of inflammatory response to antigenic stimulus GO:0002862 TAS
    glucose metabolic process GO:0006006 IEA
    regulation of transcription by RNA polymerase II GO:0006357 ISS
    transcription by RNA polymerase II GO:0006366 IEA
    apoptotic process GO:0006915 IEA
    chemotaxis GO:0006935 TAS
    signal transduction GO:0007165 TAS
    cell surface receptor signaling pathway GO:0007166 TAS
    cell surface receptor protein serine/threonine kinase signaling pathway GO:0007178 IEA
    JNK cascade GO:0007254 IEA
    skeletal muscle tissue development GO:0007519 IEA
    positive regulation of gene expression GO:0010628 IGI
    positive regulation of gene expression GO:0010628 IMP
    positive regulation of myotube differentiation GO:0010831 ISS
    peptidyl-serine phosphorylation GO:0018105 ISS
    fatty acid oxidation GO:0019395 IEA
    platelet activation GO:0030168 TAS
    regulation of ossification GO:0030278 IEA
    osteoclast differentiation GO:0030316 ISS
    stress-activated protein kinase signaling cascade GO:0031098 IDA
    positive regulation of cyclase activity GO:0031281 IMP
    lipopolysaccharide-mediated signaling pathway GO:0031663 IEA
    response to muramyl dipeptide GO:0032495 IEA
    positive regulation of interleukin-12 production GO:0032735 IMP
    response to insulin GO:0032868 IEA
    negative regulation of hippo signaling GO:0035331 IMP
    intracellular signal transduction GO:0035556 IBA
    intracellular signal transduction GO:0035556 IDA
    cellular response to vascular endothelial growth factor stimulus GO:0035924 IMP
    response to muscle stretch GO:0035994 IEA
    p38MAPK cascade GO:0038066 IDA
    p38MAPK cascade GO:0038066 ISS
    p38MAPK cascade GO:0038066 TAS
    positive regulation of protein import into nucleus GO:0042307 IEA
    signal transduction in response to DNA damage GO:0042770 IMP
    positive regulation of blood vessel endothelial cell migration GO:0043536 IMP
    positive regulation of erythrocyte differentiation GO:0045648 IMP
    positive regulation of myoblast differentiation GO:0045663 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    D-glucose import GO:0046323 IEA
    positive regulation of D-glucose import GO:0046326 IEA
    vascular endothelial growth factor receptor signaling pathway GO:0048010 IMP
    stem cell differentiation GO:0048863 IEA
    striated muscle cell differentiation GO:0051146 IEA
    positive regulation of muscle cell differentiation GO:0051149 TAS
    stress-activated MAPK cascade GO:0051403 IDA
    positive regulation of cardiac muscle cell proliferation GO:0060045 IEA
    bone development GO:0060348 IEA
    3'-UTR-mediated mRNA stabilization GO:0070935 TAS
    cellular response to lipopolysaccharide GO:0071222 IDA
    cellular response to lipoteichoic acid GO:0071223 IMP
    cellular response to tumor necrosis factor GO:0071356 IEA
    cellular response to ionizing radiation GO:0071479 IMP
    cellular response to UV-B GO:0071493 IDA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IEA
    positive regulation of brown fat cell differentiation GO:0090336 IEA
    cellular senescence GO:0090398 TAS
    stress-induced premature senescence GO:0090400 IMP
    cellular response to virus GO:0098586 IMP
    regulation of synaptic membrane adhesion GO:0099179 IEA
    regulation of cytokine production involved in inflammatory response GO:1900015 IDA
    positive regulation of myoblast fusion GO:1901741 ISS
    positive regulation of reactive oxygen species metabolic process GO:2000379 IMP
Subcellular Localization
    spindle pole GO:0000922 IEA
    extracellular region GO:0005576 TAS
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
    mitochondrion GO:0005739 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    nuclear speck GO:0016607 IDA
    secretory granule lumen GO:0034774 TAS
    glutamatergic synapse GO:0098978 IEA
    ficolin-1-rich granule lumen GO:1904813 TAS
 Experiment description of studies that identified MAPK14 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MAPK14
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAP2K7 5609
Biochemical Activity Homo sapiens
2 RPS6KA5 9252
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 DUSP7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 OXCT1 5019
Co-fractionation Homo sapiens
5 TRMT1L 81627
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 PPP2R4 5524
Affinity Capture-Western Homo sapiens
7 KMT2C 58508
Two-hybrid Homo sapiens
8 CNBP 7555
Affinity Capture-MS Homo sapiens
9 RIN3  
Affinity Capture-MS Homo sapiens
10 AES 166
Two-hybrid Homo sapiens
11 YWHAE 7531
Co-fractionation Homo sapiens
12 CD4 920
Biochemical Activity Homo sapiens
13 ADRB2  
Affinity Capture-MS Homo sapiens
14 MKNK2 2872
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 PAK2 5062
Affinity Capture-Western Homo sapiens
16 F2R 2149
Affinity Capture-Western Homo sapiens
17 IRAK1  
Affinity Capture-Western Homo sapiens
18 CDC25B 994
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
19 TAB1 10454
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
20 ATM 472
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
21 CALM1 801
Affinity Capture-Western Homo sapiens
22 HOXC10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SRSF2 6427
Affinity Capture-MS Homo sapiens
24 PLG 5340
Two-hybrid Homo sapiens
25 SLC12A2 6558
Affinity Capture-Western Homo sapiens
26 TGFBR1 7046
Affinity Capture-Western Homo sapiens
27 ATG13 9776
Affinity Capture-Western Homo sapiens
28 COPS5 10987
Two-hybrid Homo sapiens
29 HOXB9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 RPS6KA3 6197
Affinity Capture-Western Homo sapiens
31 HDAC3 8841
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
32 ERF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 SNAPIN 23557
Two-hybrid Homo sapiens
34 ZNF142  
Two-hybrid Homo sapiens
35 BTRC 8945
Affinity Capture-Western Homo sapiens
36 ZNHIT1  
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
37 HOXA5  
Affinity Capture-MS Homo sapiens
38 SPAG9 9043
Affinity Capture-Western Homo sapiens
39 CCDC14  
Two-hybrid Homo sapiens
40 SPANXN4  
Affinity Capture-MS Homo sapiens
41 MEF2A  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
42 CCDC97  
Two-hybrid Homo sapiens
43 IQGAP1 8826
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 NPM1 4869
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
45 DCUN1D5 84259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 NRL  
Biochemical Activity Homo sapiens
47 DUSP2  
Affinity Capture-MS Homo sapiens
48 MAPK14 1432
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
49 OBSL1 23363
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 NCOA3  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
51 PTPRR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 RHBDF1 64285
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 MBP 4155
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
54 ELMSAN1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 MARCKSL1 65108
Affinity Capture-MS Homo sapiens
56 LIPG 9388
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 CDT1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
58 FBXW8 26259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 YY1AP1 55249
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
60 RECQL4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 TFCP2 7024
Biochemical Activity Homo sapiens
62 CSNK2B 1460
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
63 ADSS 159
Co-fractionation Homo sapiens
64 ARHGAP9 64333
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
65 EEF1A1 1915
Two-hybrid Homo sapiens
66 GPR156  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 DYRK1B  
Biochemical Activity Homo sapiens
68 WDR1 9948
Co-fractionation Homo sapiens
69 PAK1 5058
Affinity Capture-Western Homo sapiens
70 PAK3  
Affinity Capture-Western Homo sapiens
71 MAPK1 5594
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
72 RB1 5925
Biochemical Activity Homo sapiens
73 LCOR 84458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 KRT8 3856
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
75 TOLLIP 54472
Affinity Capture-Western Homo sapiens
76 BCAR1 9564
Affinity Capture-MS Homo sapiens
77 MAPK8 5599
Affinity Capture-Western Homo sapiens
78 FOXC1  
Affinity Capture-Western Homo sapiens
79 MAPK3 5595
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Co-localization Homo sapiens
80 NEB 4703
Affinity Capture-MS Homo sapiens
81 MAP2K4 6416
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
82 USP11 8237
Affinity Capture-MS Homo sapiens
83 TCEAL1  
Affinity Capture-MS Homo sapiens
84 HIVEP1 3096
Two-hybrid Homo sapiens
85 BEX4  
Affinity Capture-MS Homo sapiens
86 SMEK1 55671
Two-hybrid Homo sapiens
87 GDF15 9518
Two-hybrid Homo sapiens
88 CBL 867
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
89 ATF2  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
90 MAPKAPK3 7867
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 PPIL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 Rps6kb1  
Reconstituted Complex Mus musculus
93 FAM19A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 STAB2 55576
Affinity Capture-Western Homo sapiens
95 MAPT  
Biochemical Activity Homo sapiens
96 JUN 3725
Biochemical Activity Homo sapiens
97 CSNK1G2 1455
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 SH2D1A 4068
Biochemical Activity Homo sapiens
99 MYLK3 91807
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 VPRBP 9730
Affinity Capture-MS Homo sapiens
101 GORASP2 26003
Biochemical Activity Homo sapiens
102 U2AF2 11338
Affinity Capture-RNA Homo sapiens
Protein-RNA Homo sapiens
103 C9orf170  
Affinity Capture-MS Homo sapiens
104 CEP164  
Two-hybrid Homo sapiens
105 ULK1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
106 CENPC  
Two-hybrid Homo sapiens
107 ARL13B 200894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 RRP1B 23076
Affinity Capture-MS Homo sapiens
109 EIF4EBP1  
Biochemical Activity Homo sapiens
110 ETV1  
Biochemical Activity Homo sapiens
111 CAMKK2 10645
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 SRPK1 6732
Biochemical Activity Homo sapiens
113 MAPK11  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
114 NFATC4 4776
Co-localization Homo sapiens
115 GATA3  
Biochemical Activity Homo sapiens
116 GTSF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 SP1  
Affinity Capture-Western Homo sapiens
118 STK39 27347
Affinity Capture-Western Homo sapiens
119 TPX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 DDX26B  
Two-hybrid Homo sapiens
121 PTPN11 5781
Co-fractionation Homo sapiens
122 HOXA10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 DUSP1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
124 EPS15 2060
Biochemical Activity Homo sapiens
125 MAZ 4150
Affinity Capture-MS Homo sapiens
126 HTRA2 27429
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
127 ATF6  
Affinity Capture-Western Homo sapiens
128 RICTOR 253260
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 TYMS 7298
Co-fractionation Homo sapiens
130 CDC25A  
Reconstituted Complex Homo sapiens
131 RALB 5899
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 ROBO1 6091
Two-hybrid Homo sapiens
133 PIAS2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
134 EEF2 1938
Affinity Capture-MS Homo sapiens
135 NFKBIA  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
136 RPS6KA4 8986
Reconstituted Complex Homo sapiens
Phenotypic Enhancement Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 TAB2  
Affinity Capture-Western Homo sapiens
138 PAK6 56924
Two-hybrid Homo sapiens
139 SRSF5 6430
Two-hybrid Homo sapiens
140 RPL41  
Two-hybrid Homo sapiens
141 EGFR 1956
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
142 MYO19  
Affinity Capture-MS Homo sapiens
143 RNF138  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 METTL21B  
Affinity Capture-MS Homo sapiens
145 METTL3  
Biochemical Activity Homo sapiens
146 DUSP16  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 SPTBN1 6711
Two-hybrid Homo sapiens
148 DUSP6 1848
Affinity Capture-Western Homo sapiens
149 TRAPPC1 58485
Affinity Capture-MS Homo sapiens
150 PTPN7 5778
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 CDC25C  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
152 MAP2K3 5606
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 PI4K2B 55300
Biochemical Activity Homo sapiens
154 MOB3B  
Two-hybrid Homo sapiens
155 RPA3 6119
Proximity Label-MS Homo sapiens
156 NME1 4830
Co-fractionation Homo sapiens
157 PDX1  
Affinity Capture-Western Homo sapiens
158 MAPKAPK5 8550
Two-hybrid Homo sapiens
159 DLX6  
Affinity Capture-MS Homo sapiens
160 RPL22 6146
Two-hybrid Homo sapiens
161 MYEF2 50804
Affinity Capture-Western Homo sapiens
162 DUSP9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
163 BICD1 636
Two-hybrid Homo sapiens
164 AMMECR1L 83607
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 PRKY  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 BMI1  
Biochemical Activity Homo sapiens
167 HOXB6 3216
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
168 HSPD1 3329
Co-fractionation Homo sapiens
169 AKT1 207
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
170 MEF2C  
Two-hybrid Homo sapiens
171 FOXK1 221937
Affinity Capture-MS Homo sapiens
172 SUPT20H 55578
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
173 CCDC8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
174 C6orf222  
Affinity Capture-MS Homo sapiens
175 NGB  
Reconstituted Complex Homo sapiens
176 RELA 5970
Two-hybrid Homo sapiens
177 MUC12  
Two-hybrid Homo sapiens
178 MAPKAPK2 9261
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
179 NKTR  
Two-hybrid Homo sapiens
180 MED19  
Affinity Capture-MS Homo sapiens
181 MAP2K6 5608
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
182 UGT2B10  
Two-hybrid Homo sapiens
183 KIF22  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
184 GMFB 2764
Affinity Capture-Western Homo sapiens
185 PLCB2  
Affinity Capture-Western Homo sapiens
186 DUSP10 11221
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
187 HDGF 3068
Affinity Capture-MS Homo sapiens
188 SMAD7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
189 TP53 7157
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
190 MKNK1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
191 EPB42 2038
Two-hybrid Homo sapiens
192 SLX4IP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
193 TMEM63B 55362
Two-hybrid Homo sapiens
194 KAT2B  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
195 FLYWCH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
196 KEAP1 9817
Negative Genetic Homo sapiens
197 SNRPA 6626
Affinity Capture-MS Homo sapiens
198 IKBKB 3551
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
199 SQSTM1 8878
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
200 MAX  
Co-localization Homo sapiens
201 SP7  
Biochemical Activity Homo sapiens
202 HDAC1 3065
Co-fractionation Homo sapiens
203 TSC1 7248
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
204 MEF2D  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
205 S100A9 6280
Biochemical Activity Homo sapiens
206 CSNK2A1 1457
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
207 PPM1G 5496
Co-fractionation Homo sapiens
208 PTPN5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
209 DDIT3 1649
Biochemical Activity Homo sapiens
210 GFER  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
211 HOXC9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
212 CDK13 8621
Co-fractionation Homo sapiens
213 FLNA 2316
Two-hybrid Homo sapiens
214 TCF20  
Two-hybrid Homo sapiens
215 MYF6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
216 RBM43 375287
Affinity Capture-MS Homo sapiens
217 DUSP4 1846
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
218 ZFP36L1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
219 CUL7 9820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
220 CIZ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
221 PHC2  
PCA Homo sapiens
222 SMARCD3  
Biochemical Activity Homo sapiens
223 RPA2 6118
Proximity Label-MS Homo sapiens
224 PHF8  
Affinity Capture-MS Homo sapiens
225 USP47 55031
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
226 Dusp9  
Two-hybrid Mus musculus
227 EP300 2033
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
228 GREM2 64388
Affinity Capture-MS Homo sapiens
229 LRRC1 55227
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MAPK14 is involved
PathwayEvidenceSource
activated TAK1 mediates p38 MAPK activation TAS Reactome
Activation of PPARGC1A (PGC-1alpha) by phosphorylation IEA Reactome
Activation of the AP-1 family of transcription factors TAS Reactome
ADP signalling through P2Y purinoceptor 1 TAS Reactome
Anti-inflammatory response favouring Leishmania parasite infection TAS Reactome
CD163 mediating an anti-inflammatory response TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Developmental Biology IEA Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
ERK/MAPK targets TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
Hemostasis TAS Reactome
Immune System TAS Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Interleukin-17 signaling TAS Reactome
KSRP (KHSRP) binds and destabilizes mRNA IEA Reactome
Leishmania infection TAS Reactome
Leishmania parasite growth and survival TAS Reactome
MAP kinase activation TAS Reactome
MAPK targets/ Nuclear events mediated by MAP kinases TAS Reactome
Metabolism of RNA IEA Reactome
MITF-M-dependent gene expression TAS Reactome
MITF-M-regulated melanocyte development TAS Reactome
Mitochondrial biogenesis IEA Reactome
MyD88 cascade initiated on plasma membrane TAS Reactome
MyD88 dependent cascade initiated on endosome TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
Myogenesis IEA Reactome
Myogenesis TAS Reactome
Neutrophil degranulation TAS Reactome
NOD1/2 Signaling Pathway TAS Reactome
Nuclear Events (kinase and transcription factor activation) TAS Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TAS Reactome
Organelle biogenesis and maintenance IEA Reactome
Oxidative Stress Induced Senescence TAS Reactome
p38MAPK events TAS Reactome
p38MAPK events IEA Reactome
Parasitic Infection Pathways TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet homeostasis TAS Reactome
Platelet sensitization by LDL TAS Reactome
Regulation of MITF-M-dependent genes involved in pigmentation TAS Reactome
Regulation of mRNA stability by proteins that bind AU-rich elements IEA Reactome
Regulation of TP53 Activity TAS Reactome
Regulation of TP53 Activity through Phosphorylation TAS Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases Activate NADPH Oxidases TAS Reactome
RNA Polymerase II Transcription TAS Reactome
Signal amplification TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by Interleukins TAS Reactome
Signaling by NTRK1 (TRKA) TAS Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRKs TAS Reactome
Signaling by NTRKs IEA Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by VEGF TAS Reactome
Signalling to ERKs TAS Reactome
Signalling to ERKs IEA Reactome
Signalling to RAS TAS Reactome
Signalling to RAS IEA Reactome
Toll Like Receptor 10 (TLR10) Cascade TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor 5 (TLR5) Cascade TAS Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade TAS Reactome
Toll Like Receptor 9 (TLR9) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
VEGFA-VEGFR2 Pathway TAS Reactome





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