Gene description for MAPK14
Gene name	mitogen-activated protein kinase 14
Gene symbol	MAPK14
Other names/aliases	CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA
Species	Homo sapiens
Database cross references - MAPK14
ExoCarta	ExoCarta_1432
Entrez Gene	1432
HGNC	6876
MIM	600289
UniProt	Q16539
MAPK14 identified in exosomes derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113
Squamous carcinoma cells	20124223

Gene ontology annotations for MAPK14

Molecular Function     ATP binding GO:0005524 IEA     MAP kinase kinase activity GO:0004708 TAS     protein binding GO:0005515 IPI     MAP kinase activity GO:0004707 IDA     NFAT protein binding GO:0051525 ISS     protein serine/threonine kinase activity GO:0004674 TAS Biological Process     stress-activated MAPK cascade GO:0051403 TAS     angiogenesis GO:0001525 IEA     innate immune response GO:0045087 TAS     toll-like receptor 10 signaling pathway GO:0034166 TAS     signal transduction GO:0007165 TAS     cellular response to ionizing radiation GO:0071479 IMP     peptidyl-serine phosphorylation GO:0018105 ISS     p38MAPK cascade GO:0038066 ISS     intracellular signal transduction GO:0035556 IDA     gene expression GO:0010467 TAS     positive regulation of myotube differentiation GO:0010831 ISS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     toll-like receptor signaling pathway GO:0002224 TAS     platelet activation GO:0030168 TAS     cell morphogenesis GO:0000902 IEA     positive regulation of myoblast differentiation GO:0045663 ISS     blood coagulation GO:0007596 TAS     muscle cell differentiation GO:0042692 TAS     positive regulation of reactive oxygen species metabolic process GO:2000379 IMP     apoptotic process GO:0006915 IEA     myoblast differentiation involved in skeletal muscle regeneration GO:0014835 IEA     skeletal muscle tissue development GO:0007519 IEA     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     mitochondrion organization GO:0007005 TAS     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     response to muramyl dipeptide GO:0032495 IEA     regulation of sequence-specific DNA binding transcription factor activity GO:0051090 TAS     positive regulation of myoblast fusion GO:1901741 ISS     cellular response to lipopolysaccharide GO:0071222 IDA     negative regulation of canonical Wnt signaling pathway GO:0090090 IEA     activation of MAPK activity GO:0000187 TAS     cellular response to vascular endothelial growth factor stimulus GO:0035924 IMP     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     toll-like receptor 4 signaling pathway GO:0034142 TAS     lipopolysaccharide-mediated signaling pathway GO:0031663 IEA     positive regulation of protein import into nucleus GO:0042307 IEA     positive regulation of brown fat cell differentiation GO:0090336 IEA     stress-induced premature senescence GO:0090400 IMP     chemotaxis GO:0006935 TAS     regulation of cytokine production involved in inflammatory response GO:1900015 IDA     striated muscle cell differentiation GO:0051146 IEA     signal transduction in response to DNA damage GO:0042770 IMP     Ras protein signal transduction GO:0007265 TAS     glucose metabolic process GO:0006006 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA     DNA damage checkpoint GO:0000077 IEA     positive regulation of muscle cell differentiation GO:0051149 TAS     positive regulation of erythrocyte differentiation GO:0045648 IEA     toll-like receptor 5 signaling pathway GO:0034146 TAS     organelle organization GO:0006996 TAS     cell surface receptor signaling pathway GO:0007166 TAS     cartilage condensation GO:0001502 IEA     positive regulation of cyclase activity GO:0031281 IMP     toll-like receptor 3 signaling pathway GO:0034138 TAS     fatty acid oxidation GO:0019395 IEA     3'-UTR-mediated mRNA stabilization GO:0070935 TAS     toll-like receptor 9 signaling pathway GO:0034162 TAS     positive regulation of blood vessel endothelial cell migration GO:0043536 IMP     transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 IEA     chondrocyte differentiation GO:0002062 IEA     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     transcription, DNA-templated GO:0006351 IEA     osteoclast differentiation GO:0030316 ISS     movement of cell or subcellular component GO:0006928 TAS     toll-like receptor 2 signaling pathway GO:0034134 TAS     regulation of transcription from RNA polymerase II promoter GO:0006357 ISS Subcellular Localization     cytosol GO:0005829 TAS     nucleoplasm GO:0005654 TAS     mitochondrion GO:0005739 IEA     extracellular exosome GO:0070062 IDA     spindle pole GO:0000922 IEA     nucleus GO:0005634 ISS     cytoplasm GO:0005737 ISS