Gene description for RHBDF1
Gene name rhomboid 5 homolog 1 (Drosophila)
Gene symbol RHBDF1
Other names/aliases C16orf8
Dist1
EGFR-RS
gene-89
gene-90
hDist1
Species Homo sapiens
 Database cross references - RHBDF1
ExoCarta ExoCarta_64285
Entrez Gene 64285
HGNC 20561
MIM 614403
UniProt Q96CC6  
 RHBDF1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for RHBDF1
Molecular Function
    serine-type endopeptidase activity GO:0004252 IDA
    growth factor binding GO:0019838 IEA
Biological Process
    protein processing GO:0016485 IBA
    cell migration GO:0016477 IMP
    regulation of proteasomal protein catabolic process GO:0061136 IDA
    regulation of protein secretion GO:0050708 IMP
    protein transport GO:0015031 IEA
    negative regulation of protein secretion GO:0050709 IDA
    cell proliferation GO:0008283 IMP
    regulation of epidermal growth factor receptor signaling pathway GO:0042058 IMP
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IDA
    Golgi membrane GO:0000139 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified RHBDF1 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RHBDF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RHBDF1 is involved
No pathways found





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