Gene description for CAMKK2
Gene name calcium/calmodulin-dependent protein kinase kinase 2, beta
Gene symbol CAMKK2
Other names/aliases CAMKK
CAMKKB
Species Homo sapiens
 Database cross references - CAMKK2
ExoCarta ExoCarta_10645
Vesiclepedia VP_10645
Entrez Gene 10645
HGNC 1470
MIM 615002
UniProt Q96RR4  
 CAMKK2 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for CAMKK2
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IBA
    calcium/calmodulin-dependent protein kinase activity GO:0004683 IEA
    protein tyrosine kinase activity GO:0004713 TAS
    calcium ion binding GO:0005509 IDA
    calmodulin binding GO:0005516 TAS
    ATP binding GO:0005524 IEA
    protein serine kinase activity GO:0106310 IEA
Biological Process
    MAPK cascade GO:0000165 TAS
    positive regulation of protein phosphorylation GO:0001934 IMP
    protein phosphorylation GO:0006468 IDA
    calcium-mediated signaling GO:0019722 TAS
    cellular response to reactive oxygen species GO:0034614 TAS
    regulation of protein kinase activity GO:0045859 TAS
    positive regulation of DNA-templated transcription GO:0045893 TAS
    protein autophosphorylation GO:0046777 IDA
    CAMKK-AMPK signaling cascade GO:0061762 IBA
    CAMKK-AMPK signaling cascade GO:0061762 IMP
    positive regulation of autophagy of mitochondrion GO:1903599 IC
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IDA
    cytosol GO:0005829 IMP
    cytosol GO:0005829 TAS
    neuron projection GO:0043005 IEA
 Experiment description of studies that identified CAMKK2 in exosomes
1
Experiment ID 275
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for CAMKK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNAJC7 7266
Proximity Label-MS Homo sapiens
2 SFN 2810
Affinity Capture-MS Homo sapiens
3 FAM196A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PRKAB1 5564
Affinity Capture-MS Homo sapiens
5 SMC3 9126
Affinity Capture-MS Homo sapiens
6 SLC25A11 8402
Affinity Capture-MS Homo sapiens
7 PRKAG1 5571
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 NPAS1  
Affinity Capture-MS Homo sapiens
9 PRKY  
Affinity Capture-MS Homo sapiens
10 NEDD4 4734
Reconstituted Complex Homo sapiens
11 CEP63  
Two-hybrid Homo sapiens
12 IREB2 3658
Affinity Capture-MS Homo sapiens
13 CALM2 805
Affinity Capture-MS Homo sapiens
14 PRKAA2 5563
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 CDC37 11140
Affinity Capture-MS Homo sapiens
16 INF2 64423
Affinity Capture-MS Homo sapiens
17 IRAK1  
Affinity Capture-MS Homo sapiens
18 FANCI 55215
Affinity Capture-MS Homo sapiens
19 CALM1 801
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 THAP11 57215
Affinity Capture-MS Homo sapiens
21 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
22 FILIP1  
Affinity Capture-MS Homo sapiens
23 FKBP5 2289
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 GCN1L1 10985
Affinity Capture-MS Homo sapiens
25 PRKDC 5591
Affinity Capture-MS Homo sapiens
26 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
27 GCHFR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 C6orf141  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 PRKACA 5566
Biochemical Activity Homo sapiens
30 ZBTB33  
Affinity Capture-MS Homo sapiens
31 ESYT2 57488
Affinity Capture-MS Homo sapiens
32 DNAI2  
Affinity Capture-MS Homo sapiens
33 DYRK1A 1859
Affinity Capture-MS Homo sapiens
34 ATG4B 23192
Affinity Capture-MS Homo sapiens
35 MYL4 4635
Affinity Capture-MS Homo sapiens
36 FLNA 2316
Affinity Capture-MS Homo sapiens
37 METTL21B  
Affinity Capture-MS Homo sapiens
38 FLNC 2318
Affinity Capture-MS Homo sapiens
39 XPOT 11260
Affinity Capture-MS Homo sapiens
40 SGK1  
Affinity Capture-Western Homo sapiens
41 CALM3 808
Affinity Capture-MS Homo sapiens
42 SMC1A 8243
Affinity Capture-MS Homo sapiens
43 MAPK14 1432
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 OBSL1 23363
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 DUSP16  
Affinity Capture-MS Homo sapiens
46 ALOX5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 HINT1 3094
Affinity Capture-MS Homo sapiens
48 ATG7 10533
Affinity Capture-MS Homo sapiens
49 IQGAP2 10788
Affinity Capture-MS Homo sapiens
50 UBXN6 80700
Affinity Capture-MS Homo sapiens
51 CAMK1 8536
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which CAMKK2 is involved
PathwayEvidenceSource
Activation of AMPK downstream of NMDARs IEA Reactome
Activation of NMDA receptors and postsynaptic events IEA Reactome
Activation of NMDA receptors and postsynaptic events TAS Reactome
Activation of RAC1 downstream of NMDARs TAS Reactome
Activation of RAC1 downstream of NMDARs IEA Reactome
Ca-dependent events IEA Reactome
Ca-dependent events TAS Reactome
Calmodulin induced events IEA Reactome
Calmodulin induced events TAS Reactome
CaM pathway IEA Reactome
CaM pathway TAS Reactome
CaMK IV-mediated phosphorylation of CREB IEA Reactome
CaMK IV-mediated phosphorylation of CREB TAS Reactome
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde IEA Reactome
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde TAS Reactome
DAG and IP3 signaling IEA Reactome
DAG and IP3 signaling TAS Reactome
G alpha (i) signalling events IEA Reactome
G alpha (i) signalling events TAS Reactome
G-protein mediated events IEA Reactome
G-protein mediated events TAS Reactome
GPCR downstream signalling IEA Reactome
GPCR downstream signalling TAS Reactome
Intracellular signaling by second messengers IEA Reactome
Intracellular signaling by second messengers TAS Reactome
Neuronal System IEA Reactome
Neuronal System TAS Reactome
Neurotransmitter receptors and postsynaptic signal transmission IEA Reactome
Neurotransmitter receptors and postsynaptic signal transmission TAS Reactome
Opioid Signalling IEA Reactome
Opioid Signalling TAS Reactome
PLC beta mediated events IEA Reactome
PLC beta mediated events TAS Reactome
Post NMDA receptor activation events IEA Reactome
Post NMDA receptor activation events TAS Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
Signaling by GPCR IEA Reactome
Signaling by GPCR TAS Reactome
Transmission across Chemical Synapses IEA Reactome
Transmission across Chemical Synapses TAS Reactome





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