Gene description for DUSP10
Gene name	dual specificity phosphatase 10
Gene symbol	DUSP10
Other names/aliases	MKP-5 MKP5
Species	Homo sapiens
Database cross references - DUSP10
ExoCarta	ExoCarta_11221
Vesiclepedia	VP_11221
Entrez Gene	11221
HGNC	3065
MIM	608867
UniProt	Q9Y6W6
DUSP10 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for DUSP10

Molecular Function     non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA     protein binding GO:0005515 IPI     protein tyrosine/threonine phosphatase activity GO:0008330 IBA     protein tyrosine/threonine phosphatase activity GO:0008330 IDA     JUN kinase binding GO:0008432 IDA     phosphatase activity GO:0016791 IDA     MAP kinase tyrosine/serine/threonine phosphatase activity GO:0017017 IBA     myosin phosphatase activity GO:0017018 IEA     protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA     calmodulin-dependent protein phosphatase activity GO:0033192 IEA     MAP kinase phosphatase activity GO:0033549 IDA     MAP kinase phosphatase activity GO:0033549 ISS     MAP kinase tyrosine phosphatase activity GO:0033550 IBA     mitogen-activated protein kinase p38 binding GO:0048273 IPI     histone H2AXS140 phosphatase activity GO:0140791 IEA     histone H2AXY142 phosphatase activity GO:0140793 IEA     RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA     RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA     RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA     RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA     RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA     MAP kinase serine/threonine phosphatase activity GO:1990439 IEA Biological Process     regulation of adaptive immune response GO:0002819 IEA     chromatin remodeling GO:0006338 IEA     regulation of transcription by RNA polymerase II GO:0006357 IEA     signal transduction GO:0007165 IBA     negative regulation of epithelial cell migration GO:0010633 ISS     dephosphorylation GO:0016311 IDA     negative regulation of cell migration GO:0030336 NAS     response to lipopolysaccharide GO:0032496 IEA     negative regulation of stress-activated MAPK cascade GO:0032873 IEA     peptidyl-threonine dephosphorylation GO:0035970 IDA     negative regulation of JUN kinase activity GO:0043508 IDA     positive regulation of regulatory T cell differentiation GO:0045591 IMP     negative regulation of JNK cascade GO:0046329 IBA     negative regulation of JNK cascade GO:0046329 IDA     oligodendrocyte differentiation GO:0048709 IEA     negative regulation of oligodendrocyte differentiation GO:0048715 IEA     negative regulation of epithelial cell proliferation GO:0050680 ISS     stress-activated MAPK cascade GO:0051403 IEA     negative regulation of respiratory burst involved in inflammatory response GO:0060266 IEA     negative regulation of ERK1 and ERK2 cascade GO:0070373 ISS     regulation of brown fat cell differentiation GO:0090335 IEA     negative regulation of p38MAPK cascade GO:1903753 IDA     negative regulation of p38MAPK cascade GO:1903753 NAS     negative regulation of epithelium regeneration GO:1905042 ISS     peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity GO:1990264 IDA Subcellular Localization     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     cytosol GO:0005829 IBA     cytosol GO:0005829 IDA