Gene description for DUSP10
Gene name dual specificity phosphatase 10
Gene symbol DUSP10
Other names/aliases MKP-5
MKP5
Species Homo sapiens
 Database cross references - DUSP10
ExoCarta ExoCarta_11221
Entrez Gene 11221
HGNC 3065
MIM 608867
UniProt Q9Y6W6  
 DUSP10 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for DUSP10
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IEA
    phosphatase activity GO:0016791 IDA
    phosphoprotein phosphatase activity GO:0004721 TAS
    MAP kinase tyrosine/serine/threonine phosphatase activity GO:0017017 IEA
    protein tyrosine/serine/threonine phosphatase activity GO:0008138 IBA
    MAP kinase phosphatase activity GO:0033549 IDA
Biological Process
    negative regulation of respiratory burst involved in inflammatory response GO:0060266 IEA
    JNK cascade GO:0007254 TAS
    inactivation of MAPK activity GO:0000188 IDA
    response to lipopolysaccharide GO:0032496 IEA
    regulation of brown fat cell differentiation GO:0090335 IEA
    negative regulation of protein kinase activity by regulation of protein phosphorylation GO:0044387 IEA
    regulation of adaptive immune response GO:0002819 IEA
    peptidyl-tyrosine dephosphorylation GO:0035335 IEA
    response to stress GO:0006950 TAS
    negative regulation of JUN kinase activity GO:0043508 IBA
    oligodendrocyte differentiation GO:0048709 IEA
    protein dephosphorylation GO:0006470 IDA
    negative regulation of oligodendrocyte differentiation GO:0048715 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 TAS
    nucleus GO:0005634 TAS
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified DUSP10 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DUSP10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAPK8 5599
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 MAPK10 5602
Affinity Capture-Western Homo sapiens
3 MAPK14 1432
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
4 MAPK9 5601
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which DUSP10 is involved
No pathways found





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