Gene description for ROR2
Gene name receptor tyrosine kinase-like orphan receptor 2
Gene symbol ROR2
Other names/aliases BDB
BDB1
NTRKR2
Species Homo sapiens
 Database cross references - ROR2
ExoCarta ExoCarta_4920
Vesiclepedia VP_4920
Entrez Gene 4920
HGNC 10257
MIM 602337
UniProt Q01974  
 ROR2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for ROR2
Molecular Function
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IBA
    GPI-linked ephrin receptor activity GO:0005004 IEA
    transmembrane-ephrin receptor activity GO:0005005 IEA
    epidermal growth factor receptor activity GO:0005006 IEA
    fibroblast growth factor receptor activity GO:0005007 IEA
    hepatocyte growth factor receptor activity GO:0005008 IEA
    insulin receptor activity GO:0005009 IEA
    insulin-like growth factor receptor activity GO:0005010 IEA
    macrophage colony-stimulating factor receptor activity GO:0005011 IEA
    platelet-derived growth factor alpha-receptor activity GO:0005018 IEA
    platelet-derived growth factor beta-receptor activity GO:0005019 IEA
    stem cell factor receptor activity GO:0005020 IEA
    vascular endothelial growth factor receptor activity GO:0005021 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    boss receptor activity GO:0008288 IEA
    coreceptor activity GO:0015026 TAS
    Wnt-protein binding GO:0017147 IBA
    Wnt-protein binding GO:0017147 IPI
    mitogen-activated protein kinase kinase kinase binding GO:0031435 IPI
    histone H3Y41 kinase activity GO:0035401 IEA
    placental growth factor receptor activity GO:0036332 IEA
    protein tyrosine kinase collagen receptor activity GO:0038062 IEA
    metal ion binding GO:0046872 IEA
    brain-derived neurotrophic factor receptor activity GO:0060175 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    signal transduction GO:0007165 IMP
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    epidermal growth factor receptor signaling pathway GO:0007173 IEA
    multicellular organism development GO:0007275 IBA
    insulin receptor signaling pathway GO:0008286 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 IEA
    astrocyte development GO:0014002 IEA
    Wnt signaling pathway GO:0016055 IEA
    bone mineralization GO:0030282 IEA
    positive regulation of cell migration GO:0030335 IDA
    male genitalia development GO:0030539 IEA
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA
    platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA
    platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA
    vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA
    collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA
    vascular endothelial growth factor signaling pathway GO:0038084 IEA
    Kit signaling pathway GO:0038109 IEA
    macrophage colony-stimulating factor signaling pathway GO:0038145 IEA
    positive regulation of macrophage differentiation GO:0045651 IEA
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    hepatocyte growth factor receptor signaling pathway GO:0048012 IEA
    ephrin receptor signaling pathway GO:0048013 IEA
    positive regulation of synaptic transmission, glutamatergic GO:0051968 IEA
    regulation of postsynapse organization GO:0099175 IEA
    regulation of synaptic signaling by nitric oxide GO:0150045 IEA
    macrophage migration GO:1905517 IEA
Subcellular Localization
    microtubule GO:0005874 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IEA
    axon GO:0030424 IBA
    dendrite GO:0030425 IEA
    clathrin-coated endocytic vesicle membrane GO:0030669 TAS
    neuronal cell body GO:0043025 IEA
    receptor complex GO:0043235 IBA
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified ROR2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ROR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C3orf56  
Two-hybrid Homo sapiens
2 GJD3  
Proximity Label-MS Homo sapiens
3 ISX  
Two-hybrid Homo sapiens
4 RBPMS 11030
Two-hybrid Homo sapiens
5 OCLN 100506658
Proximity Label-MS Homo sapiens
6 METTL7A 25840
Proximity Label-MS Homo sapiens
7 LAMP3  
Proximity Label-MS Homo sapiens
8 ATG9A 79065
Proximity Label-MS Homo sapiens
9 HLA-E 3133
Affinity Capture-MS Homo sapiens
10 GJA1 2697
Proximity Label-MS Homo sapiens
11 PARD3 56288
Proximity Label-MS Homo sapiens
12 C19orf54  
Two-hybrid Homo sapiens
13 ZNF34  
Two-hybrid Homo sapiens
14 ECEL1  
Affinity Capture-MS Homo sapiens
15 DAB1 1600
Two-hybrid Homo sapiens
16 GAA 2548
Affinity Capture-MS Homo sapiens
17 LAMP2 3920
Proximity Label-MS Homo sapiens
18 DNAJC25 548645
Proximity Label-MS Homo sapiens
19 SLURP1  
Affinity Capture-MS Homo sapiens
20 STX4 6810
Proximity Label-MS Homo sapiens
21 SLC22A9  
Affinity Capture-MS Homo sapiens
22 KLK2  
Affinity Capture-MS Homo sapiens
23 PTPN20B  
Two-hybrid Homo sapiens
24 ATXN7L1 222255
Two-hybrid Homo sapiens
25 KRTAP19-7  
Two-hybrid Homo sapiens
26 B3GAT1  
Proximity Label-MS Homo sapiens
27 MLLT4 4301
Proximity Label-MS Homo sapiens
28 PTPN12 5782
Two-hybrid Homo sapiens
29 STOX1  
Two-hybrid Homo sapiens
30 ASIC1  
Affinity Capture-MS Homo sapiens
31 PPP3CB  
Two-hybrid Homo sapiens
32 DUSP14 11072
Two-hybrid Homo sapiens
33 MTMR2 8898
Two-hybrid Homo sapiens
34 CD3E 916
Affinity Capture-MS Homo sapiens
35 PTPRR  
Two-hybrid Homo sapiens
36 ACVR2B  
Affinity Capture-MS Homo sapiens
37 SOX14  
Two-hybrid Homo sapiens
38 PPM1A 5494
Two-hybrid Homo sapiens
39 STX6 10228
Proximity Label-MS Homo sapiens
40 ARID5A  
Two-hybrid Homo sapiens
41 RAB35 11021
Proximity Label-MS Homo sapiens
42 ELSPBP1  
Affinity Capture-MS Homo sapiens
43 BTNL2  
Affinity Capture-MS Homo sapiens
44 TMEM106A  
Affinity Capture-MS Homo sapiens
45 STYX  
Two-hybrid Homo sapiens
46 ERBB2 2064
PCA Homo sapiens
47 EBAG9 9166
Proximity Label-MS Homo sapiens
48 PRR20C  
Two-hybrid Homo sapiens
49 MARCKS 4082
Proximity Label-MS Homo sapiens
50 LAMTOR1 55004
Proximity Label-MS Homo sapiens
51 PRR20A  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
52 PPM1B 5495
Two-hybrid Homo sapiens
53 PTPN6 5777
Two-hybrid Homo sapiens
54 BRICD5  
Affinity Capture-MS Homo sapiens
55 TLX3  
Two-hybrid Homo sapiens
56 CXADR 1525
Proximity Label-MS Homo sapiens
57 MSX2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
58 LYN 4067
Proximity Label-MS Homo sapiens
59 DAZAP2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
60 DNAJC5 80331
Proximity Label-MS Homo sapiens
61 KRTAP6-2  
Two-hybrid Homo sapiens
62 SDF2L1 23753
Affinity Capture-MS Homo sapiens
63 DIRAS3  
Proximity Label-MS Homo sapiens
64 NTRK1 4914
Affinity Capture-MS Homo sapiens
65 C10orf55  
Two-hybrid Homo sapiens
66 DTX2 113878
Proximity Label-MS Homo sapiens
67 RAB2A 5862
Proximity Label-MS Homo sapiens
68 MTMR1 8776
Two-hybrid Homo sapiens
69 FOSB  
Two-hybrid Homo sapiens
70 VENTX  
Two-hybrid Homo sapiens
71 LY86  
Affinity Capture-MS Homo sapiens
72 ZMYM4  
Two-hybrid Homo sapiens
73 PCDHA8  
Affinity Capture-MS Homo sapiens
74 CDC14A  
Two-hybrid Homo sapiens
75 PTPN11 5781
Two-hybrid Homo sapiens
76 DUSP1  
Two-hybrid Homo sapiens
77 LHX6  
Two-hybrid Homo sapiens
78 RAB5A 5868
Proximity Label-MS Homo sapiens
79 PANX1 24145
Proximity Label-MS Homo sapiens
80 ILKAP 80895
Two-hybrid Homo sapiens
81 EPB41L4A 64097
Proximity Label-MS Homo sapiens
82 RNF43  
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
83 TAB1 10454
Two-hybrid Homo sapiens
84 BHLHE40  
Two-hybrid Homo sapiens
85 PRR20D  
Two-hybrid Homo sapiens
86 CLEC4A  
Affinity Capture-MS Homo sapiens
87 EYA2  
Two-hybrid Homo sapiens
88 KLRD1  
Affinity Capture-MS Homo sapiens
89 ARF6 382
Proximity Label-MS Homo sapiens
90 MAP3K7  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
91 DUSP6 1848
Two-hybrid Homo sapiens
92 NXF1 10482
Affinity Capture-RNA Homo sapiens
93 CRX  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
94 PTPN7 5778
Two-hybrid Homo sapiens
95 CDC25C  
Two-hybrid Homo sapiens
96 PRKACA 5566
Proximity Label-MS Homo sapiens
97 LYZL1  
Affinity Capture-MS Homo sapiens
98 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
99 RAB9A 9367
Proximity Label-MS Homo sapiens
100 FAM46A  
Two-hybrid Homo sapiens
101 C1orf94  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
102 DUSP21  
Two-hybrid Homo sapiens
103 RHOB 388
Proximity Label-MS Homo sapiens
104 PRKAB2 5565
Two-hybrid Homo sapiens
105 DUSP18  
Two-hybrid Homo sapiens
106 DUPD1  
Two-hybrid Homo sapiens
107 FLOT1 10211
Proximity Label-MS Homo sapiens
108 PPM1F 9647
Two-hybrid Homo sapiens
109 MTMR9 66036
Two-hybrid Homo sapiens
110 DUSP19  
Two-hybrid Homo sapiens
111 ADAM30 11085
Affinity Capture-MS Homo sapiens
112 ALG13 79868
Two-hybrid Homo sapiens
113 WNT1  
Affinity Capture-Western Homo sapiens
114 HLA-G 3135
Affinity Capture-MS Homo sapiens
115 DUSP10 11221
Two-hybrid Homo sapiens
116 RPL6 6128
Cross-Linking-MS (XL-MS) Homo sapiens
117 RPL3 6122
Cross-Linking-MS (XL-MS) Homo sapiens
118 POU2AF1  
Two-hybrid Homo sapiens
119 CD1B 910
Affinity Capture-MS Homo sapiens
120 IKBKG 8517
Reconstituted Complex Homo sapiens
121 LCK 3932
Proximity Label-MS Homo sapiens
122 B4GAT1 11041
Affinity Capture-MS Homo sapiens
123 TPTE  
Two-hybrid Homo sapiens
124 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
125 C11orf52 91894
Proximity Label-MS Homo sapiens
126 ROR2 4920
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
127 PRR20B  
Two-hybrid Homo sapiens
128 SFTPC  
Affinity Capture-MS Homo sapiens
129 OGFOD3 79701
Affinity Capture-MS Homo sapiens
130 MAGED1 9500
Affinity Capture-Western Homo sapiens
131 MOV10 4343
Affinity Capture-RNA Homo sapiens
132 PRR20E  
Two-hybrid Homo sapiens
133 DNAJC5B  
Proximity Label-MS Homo sapiens
134 UGT1A7 54577
Affinity Capture-MS Homo sapiens
135 RAB11A 8766
Proximity Label-MS Homo sapiens
136 KRTAP7-1  
Two-hybrid Homo sapiens
137 EPHA2 1969
Proximity Label-MS Homo sapiens
138 ASIC4  
Affinity Capture-MS Homo sapiens
139 KRAS 3845
Proximity Label-MS Homo sapiens
140 HLA-DRB1 3123
Affinity Capture-MS Homo sapiens
141 PCDHB3  
Affinity Capture-MS Homo sapiens
142 PTCH1  
Affinity Capture-MS Homo sapiens
143 CAV1 857
Proximity Label-MS Homo sapiens
144 FAM168B 130074
Two-hybrid Homo sapiens
145 HLA-C 3107
Affinity Capture-MS Homo sapiens
146 MTMR6 9107
Two-hybrid Homo sapiens
View the network image/svg+xml



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