Gene description for PTPN7
Gene name protein tyrosine phosphatase, non-receptor type 7
Gene symbol PTPN7
Other names/aliases BPTP-4
HEPTP
LC-PTP
LPTP
PTPNI
Species Homo sapiens
 Database cross references - PTPN7
ExoCarta ExoCarta_5778
Vesiclepedia VP_5778
Entrez Gene 5778
HGNC 9659
MIM 176889
UniProt P35236  
 PTPN7 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PTPN7
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IBA
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 TAS
    protein binding GO:0005515 IPI
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
Biological Process
    MAPK cascade GO:0000165 TAS
    chromatin remodeling GO:0006338 IEA
    protein dephosphorylation GO:0006470 TAS
    signal transduction GO:0007165 IBA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    cytoplasmic side of plasma membrane GO:0009898 IDA
    microtubule cytoskeleton GO:0015630 IDA
    mitotic spindle GO:0072686 IDA
 Experiment description of studies that identified PTPN7 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PTPN7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAPK1IP1L 93487
Affinity Capture-MS Homo sapiens
2 AATK  
Two-hybrid Homo sapiens
3 MACROD1 28992
Affinity Capture-MS Homo sapiens
4 RPS19BP1  
Affinity Capture-MS Homo sapiens
5 MAPK1 5594
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
6 CCDC57 284001
Two-hybrid Homo sapiens
7 GLB1 2720
Affinity Capture-MS Homo sapiens
8 PPP1CA 5499
Biochemical Activity Homo sapiens
9 ACAD11 84129
Affinity Capture-MS Homo sapiens
10 SIRPA 140885
Reconstituted Complex Homo sapiens
11 RPS12 6206
Affinity Capture-MS Homo sapiens
12 HSPA1L 3305
Affinity Capture-MS Homo sapiens
13 MAPK3 5595
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
14 ERBB4 2066
Two-hybrid Homo sapiens
15 EGFR 1956
Two-hybrid Homo sapiens
16 IGF1R 3480
Two-hybrid Homo sapiens
17 ERBB3 2065
Two-hybrid Homo sapiens
18 APP 351
Reconstituted Complex Homo sapiens
19 SSBP1 6742
Affinity Capture-MS Homo sapiens
20 ROR2 4920
Two-hybrid Homo sapiens
21 PTPN7 5778
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 MAPKAPK3 7867
Affinity Capture-MS Homo sapiens
23 PMPCB 9512
Affinity Capture-MS Homo sapiens
24 PRKACA 5566
Biochemical Activity Homo sapiens
25 DCAF10  
Affinity Capture-MS Homo sapiens
26 RPA3 6119
Affinity Capture-MS Homo sapiens
27 ME1 4199
Affinity Capture-MS Homo sapiens
28 PMPCA 23203
Affinity Capture-MS Homo sapiens
29 SAV1  
Affinity Capture-MS Homo sapiens
30 DHPS 1725
Affinity Capture-MS Homo sapiens
31 OPA1 4976
Affinity Capture-MS Homo sapiens
32 PNMA2  
Affinity Capture-MS Homo sapiens
33 EPHA2 1969
Two-hybrid Homo sapiens
34 HSPH1 10808
Affinity Capture-MS Homo sapiens
35 MAPK14 1432
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 GMCL1  
Two-hybrid Homo sapiens
37 MAPK11  
Affinity Capture-MS Homo sapiens
38 PTK7 5754
Two-hybrid Homo sapiens
39 PAK4 10298
Affinity Capture-MS Homo sapiens
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