Gene description for PTPN7
Gene name protein tyrosine phosphatase, non-receptor type 7
Gene symbol PTPN7
Other names/aliases BPTP-4
HEPTP
LC-PTP
LPTP
PTPNI
Species Homo sapiens
 Database cross references - PTPN7
ExoCarta ExoCarta_5778
Entrez Gene 5778
HGNC 9659
MIM 176889
UniProt P35236  
 PTPN7 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PTPN7
Molecular Function
    protein binding GO:0005515 IPI
    protein tyrosine phosphatase activity GO:0004725 IEA
Biological Process
    protein dephosphorylation GO:0006470 TAS
    peptidyl-tyrosine dephosphorylation GO:0035335 TAS
Subcellular Localization
    cytoplasmic side of plasma membrane GO:0009898 IDA
    cytoskeleton GO:0005856 IEA
    cytosol GO:0005829 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified PTPN7 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PTPN7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAPK1 5594
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
2 MAPK14 1432
Affinity Capture-MS Homo sapiens
3 MAPK3 5595
Invivo Homo sapiens
Invitro Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which PTPN7 is involved
No pathways found





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