Gene description for OPA1
Gene name optic atrophy 1 (autosomal dominant)
Gene symbol OPA1
Other names/aliases MGM1
NPG
NTG
largeG
Species Homo sapiens
 Database cross references - OPA1
ExoCarta ExoCarta_4976
Entrez Gene 4976
HGNC 8140
MIM 605290
UniProt O60313  
 OPA1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for OPA1
Molecular Function
    protein binding GO:0005515 IPI
    GTPase activity GO:0003924 TAS
    magnesium ion binding GO:0000287 NAS
    GTP binding GO:0005525 IEA
Biological Process
    cellular senescence GO:0090398 IDA
    apoptotic process GO:0006915 IEA
    negative regulation of release of cytochrome c from mitochondria GO:0090201 IMP
    mitochondrial fission GO:0000266 TAS
    mitochondrial fusion GO:0008053 TAS
    axon transport of mitochondrion GO:0019896 TAS
    neural tube closure GO:0001843 IEA
    mitochondrion organization GO:0007005 NAS
    metabolic process GO:0008152 TAS
    visual perception GO:0007601 IMP
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 IGI
    inner mitochondrial membrane organization GO:0007007 IDA
    mitochondrial genome maintenance GO:0000002 IMP
Subcellular Localization
    mitochondrial inner membrane GO:0005743 NAS
    cytoplasm GO:0005737 IDA
    integral component of membrane GO:0016021 IEA
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 IDA
    mitochondrial intermembrane space GO:0005758 ISS
    dendrite GO:0030425 ISS
    membrane GO:0016020 IDA
    mitochondrial crista GO:0030061 IDA
    mitochondrial outer membrane GO:0005741 IDA
 Experiment description of studies that identified OPA1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for OPA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which OPA1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here