ExoCarta: Gene summary

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Gene description for MTX2
Gene name	metaxin 2
Gene symbol	MTX2
Other names/aliases	-
Species	Homo sapiens
Database cross references - MTX2
ExoCarta	ExoCarta_10651
Vesiclepedia	VP_10651
Entrez Gene	10651
HGNC	7506
MIM	608555
UniProt	O75431
MTX2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Mesenchymal stem cells	36408942

Gene ontology annotations for MTX2

Molecular Function
	protein binding	GO:0005515	IPI
Biological Process
	mitochondrial transport	GO:0006839	IMP
	mitochondrion organization	GO:0007005	IBA
	inner mitochondrial membrane organization	GO:0007007	IC
	protein insertion into mitochondrial outer membrane	GO:0045040	NAS
Subcellular Localization
	SAM complex	GO:0001401	HDA
	SAM complex	GO:0001401	IBA
	SAM complex	GO:0001401	IPI
	nucleolus	GO:0005730	IDA
	cytoplasm	GO:0005737	IBA
	mitochondrion	GO:0005739	HTP
	mitochondrion	GO:0005739	IDA
	mitochondrial outer membrane	GO:0005741	NAS
	MIB complex	GO:0140275	HDA

Experiment description of studies that identified MTX2 in exosomes

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

488

MISEV standards
✔ EM	Biophysical techniques
✔ CD9\|CD81\|CD63\|GAPDH\|SDCBP\|LAMP1\|TFRC\|UCHL1\|FLOT2\|LAMP2\|FLOT1\|ICAM1\|RAB5B\|CD151\|RAB35\|TSG101\|RAB5A\|CD82	Enriched markers
✔ CANX	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Homo sapiens

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Mesenchymal stem cells

Sample name

UCMSC

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Protein-protein interactions for MTX2

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

FAM73A

Proximity Label-MS

Homo sapiens

DNAJC11

55735

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

MTCH1

23787

Proximity Label-MS

Homo sapiens

COX15

1355

Proximity Label-MS

Homo sapiens

RPA2

6118

Proximity Label-MS

Homo sapiens

TMEM184A

Affinity Capture-MS

Homo sapiens

SLC2A1

6513

Affinity Capture-MS

Homo sapiens

BNIP3L

Proximity Label-MS

Homo sapiens

FAM3B

54097

Affinity Capture-MS

Homo sapiens

HNRNPR

10236

Co-fractionation

Homo sapiens

NDUFA4

4697

Affinity Capture-MS

Homo sapiens

PTPN1

5770

Proximity Label-MS

Homo sapiens

FAXC

Affinity Capture-MS

Homo sapiens

FFAR1

Affinity Capture-MS

Homo sapiens

SOX2

Affinity Capture-MS

Homo sapiens

CCDC90B

Proximity Label-MS

Homo sapiens

PDE2A

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

C19orf70

Affinity Capture-MS

Homo sapiens

FIS1

51024

Proximity Label-MS

Homo sapiens

C9orf89

84270

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CCDC138

Proximity Label-MS

Homo sapiens

FAM174A

345757

Affinity Capture-MS

Homo sapiens

PRC1

9055

Affinity Capture-MS

Homo sapiens

TRABD

80305

Proximity Label-MS

Homo sapiens

SRRM2

23524

Proximity Label-MS

Homo sapiens

P2RY8

Affinity Capture-MS

Homo sapiens

VPS13D

55187

Proximity Label-MS

Homo sapiens

DNAJB1

3337

Affinity Capture-MS

Homo sapiens

SURF1

Proximity Label-MS

Homo sapiens

EXD2

Proximity Label-MS

Homo sapiens

PHB

5245

Affinity Capture-MS

Homo sapiens

MAVS

57506

Proximity Label-MS

Homo sapiens

HK1

3098

Proximity Label-MS

Homo sapiens

EXOC5

10640

Affinity Capture-MS

Homo sapiens

SLC25A3

5250

Co-fractionation

Homo sapiens

RBM8A

9939

Proximity Label-MS

Homo sapiens

KIF14

9928

Affinity Capture-MS

Homo sapiens

ARHGEF11

9826

Affinity Capture-MS

Homo sapiens

RHOH

Two-hybrid

Homo sapiens

APOO

79135

Proximity Label-MS

Homo sapiens

CHMP4C

92421

Affinity Capture-MS

Homo sapiens

PPP1CA

5499

Affinity Capture-MS

Homo sapiens

MTCH2

23788

Proximity Label-MS

Homo sapiens

MIB1

57534

Proximity Label-MS

Homo sapiens

SAMM50

25813

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Reconstituted Complex		Homo sapiens

DUOXA2

Affinity Capture-MS

Homo sapiens

CHRM2

Proximity Label-MS

Homo sapiens

CHCHD3

54927

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SLC2A8

29988

Affinity Capture-MS

Homo sapiens

MAPRE1

22919

Affinity Capture-MS

Homo sapiens

TPD52

7163

Affinity Capture-MS

Homo sapiens

DIABLO

56616

Proximity Label-MS

Homo sapiens

DDX20

11218

Proximity Label-MS

Homo sapiens

CHMP4B

128866

Affinity Capture-MS

Homo sapiens

AKAP9

10142

Proximity Label-MS

Homo sapiens

U2AF2

11338

Proximity Label-MS

Homo sapiens

OPA1

4976

Proximity Label-MS

Homo sapiens

YWHAQ

10971

Affinity Capture-MS

Homo sapiens

ACTB

Affinity Capture-MS

Homo sapiens

CHCHD6

84303

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MARCH2

Proximity Label-MS

Homo sapiens

DNAJC30

Proximity Label-MS

Homo sapiens

DDX39B

7919

Affinity Capture-MS

Homo sapiens

RHOT2

89941

Proximity Label-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

VDAC2

7417

Affinity Capture-MS

Homo sapiens

DNM1L

10059

Proximity Label-MS

Homo sapiens

EIF2B4

8890

Affinity Capture-MS

Homo sapiens

COX4I1

1327

Proximity Label-MS

Homo sapiens

ANLN

54443

Affinity Capture-MS

Homo sapiens

C1QTNF2

Two-hybrid

Homo sapiens

SLC25A12

8604

Proximity Label-MS

Homo sapiens

MINOS1

Affinity Capture-MS

Homo sapiens

ECT2

1894

Affinity Capture-MS

Homo sapiens

SRSF4

6429

Proximity Label-MS

Homo sapiens

UBQLN2

29978

Two-hybrid

Homo sapiens

MGARP

Affinity Capture-MS

Homo sapiens

YKT6

10652

Proximity Label-MS

Homo sapiens

RMND1

55005

Proximity Label-MS

Homo sapiens

FKBP8

23770

Proximity Label-MS

Homo sapiens

MYO19

Proximity Label-MS

Homo sapiens

CCDC155

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

MTFR1

Proximity Label-MS

Homo sapiens

OCIAD1

54940

Proximity Label-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

GEMIN4

50628

Proximity Label-MS

Homo sapiens

TADA2A

Two-hybrid

Homo sapiens

RPA3

6119

Proximity Label-MS

Homo sapiens

APOOL

139322

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RPS14

6208

Affinity Capture-MS

Homo sapiens

TXNL1

9352

Proximity Label-MS

Homo sapiens

CD244

51744

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

COL10A1

Affinity Capture-MS

Homo sapiens

CLPB

81570

Proximity Label-MS

Homo sapiens

BNIP3

664

Proximity Label-MS

Homo sapiens

RNF26

Affinity Capture-MS

Homo sapiens

LRRN4CL

221091

Affinity Capture-MS

Homo sapiens

CEP120

Affinity Capture-MS

Homo sapiens

AKAP1

8165

Proximity Label-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

UBXN4

23190

Proximity Label-MS

Homo sapiens

IMMT

10989

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

100

DNAJC4

Proximity Label-MS

Homo sapiens

101

CLPP

8192

Proximity Label-MS

Homo sapiens

102

TRAK2

66008

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

103

PLEKHA4

57664

Affinity Capture-MS

Homo sapiens

104

PHB2

11331

Affinity Capture-MS

Homo sapiens

105

ALDH3A2

224

Proximity Label-MS

Homo sapiens

106

TRIM13

Affinity Capture-MS

Homo sapiens

107

EDNRA

1909

Affinity Capture-MS

Homo sapiens

108

TDRKH

Proximity Label-MS

Homo sapiens

109

PDCL3

79031

Proximity Label-MS

Homo sapiens

110

TRAK1

22906

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

111

PARVG

64098

Affinity Capture-MS

Homo sapiens

112

MFSD4

Affinity Capture-MS

Homo sapiens

113

PDCL

5082

Proximity Label-MS

Homo sapiens

114

DNAJA2

10294

Proximity Label-MS

Homo sapiens

115

SQSTM1

8878

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

116

TRA2B

6434

Proximity Label-MS

Homo sapiens

117

MMGT1

93380

Co-fractionation

Homo sapiens

118

MFF

56947

Proximity Label-MS

Homo sapiens

119

UFL1

23376

Affinity Capture-MS

Homo sapiens

120

USP30

Proximity Label-MS

Homo sapiens

121

MOV10

4343

Affinity Capture-RNA		Homo sapiens
Proximity Label-MS		Homo sapiens

122

C19orf52

Proximity Label-MS

Homo sapiens

123

SLC25A51

Proximity Label-MS

Homo sapiens

124

CIT

11113

Affinity Capture-MS

Homo sapiens

125

MTX3

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

126

LRRC49

Proximity Label-MS

Homo sapiens

View the network

Pathways in which MTX2 is involved

Pathway	Evidence	Source
Cristae formation	IEA	Reactome
Mitochondrial biogenesis	IEA	Reactome
Mitochondrial protein import	IEA	Reactome
Organelle biogenesis and maintenance	IEA	Reactome
Protein localization	IEA	Reactome

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