Gene description for COX15
Gene name cytochrome c oxidase assembly homolog 15 (yeast)
Gene symbol COX15
Other names/aliases CEMCOX2
Species Homo sapiens
 Database cross references - COX15
ExoCarta ExoCarta_1355
Vesiclepedia VP_1355
Entrez Gene 1355
HGNC 2263
MIM 603646
UniProt Q7KZN9  
 COX15 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for COX15
Molecular Function
    protein binding GO:0005515 IPI
    oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 IMP
    oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 TAS
    oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor GO:0016653 IBA
    heme binding GO:0020037 TAS
    metal ion binding GO:0046872 IEA
Biological Process
    heme biosynthetic process GO:0006783 TAS
    heme A biosynthetic process GO:0006784 IBA
    heme A biosynthetic process GO:0006784 IEA
    heme A biosynthetic process GO:0006784 IGI
    cytochrome complex assembly GO:0017004 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IBA
    mitochondrial inner membrane GO:0005743 TAS
    cytochrome complex GO:0070069 IDA
    respiratory chain complex GO:0098803 TAS
 Experiment description of studies that identified COX15 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for COX15
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNAJC4  
Proximity Label-MS Homo sapiens
2 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
3 OCIAD1 54940
Proximity Label-MS Homo sapiens
4 CLN3 1201
Affinity Capture-MS Homo sapiens
5 SLC25A12 8604
Proximity Label-MS Homo sapiens
6 NDUFS6  
Co-fractionation Homo sapiens
7 NDUFA9 4704
Co-fractionation Homo sapiens
8 APOO 79135
Proximity Label-MS Homo sapiens
9 RPL27 6155
Affinity Capture-MS Homo sapiens
10 MRPS14  
Co-fractionation Homo sapiens
11 NDUFS4 4724
Co-fractionation Homo sapiens
12 DNAJA3 9093
Proximity Label-MS Homo sapiens
13 RMND1 55005
Proximity Label-MS Homo sapiens
14 NDUFA12 55967
Co-fractionation Homo sapiens
15 CENPV 201161
Affinity Capture-MS Homo sapiens
16 CCDC90B  
Proximity Label-MS Homo sapiens
17 ILF2 3608
Affinity Capture-MS Homo sapiens
18 MRPL15 29088
Co-fractionation Homo sapiens
19 DIABLO 56616
Proximity Label-MS Homo sapiens
20 NDUFS8 4728
Co-fractionation Homo sapiens
21 PABPC1 26986
Affinity Capture-MS Homo sapiens
22 CHMP4B 128866
Affinity Capture-MS Homo sapiens
23 COQ9  
Affinity Capture-MS Homo sapiens
24 C19orf52  
Proximity Label-MS Homo sapiens
25 SLC25A51  
Proximity Label-MS Homo sapiens
26 OPA1 4976
Proximity Label-MS Homo sapiens
27 RPL12 6136
Affinity Capture-MS Homo sapiens
28 LDLR 3949
Positive Genetic Homo sapiens
29 CYC1 1537
Co-fractionation Homo sapiens
30 DDRGK1 65992
Affinity Capture-MS Homo sapiens
31 CLPB 81570
Proximity Label-MS Homo sapiens
32 TOMM7 54543
Co-fractionation Homo sapiens
33 DNAJC30  
Proximity Label-MS Homo sapiens
34 FLOT2 2319
Affinity Capture-MS Homo sapiens
35 SURF1  
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
36 LAMTOR3 8649
Co-fractionation Homo sapiens
37 MCUR1 63933
Proximity Label-MS Homo sapiens
38 FLOT1 10211
Affinity Capture-MS Homo sapiens
39 RPL30 6156
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here