Gene description for ATP5H
Gene name ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
Gene symbol ATP5H
Other names/aliases ATPQ
Species Homo sapiens
 Database cross references - ATP5H
ExoCarta ExoCarta_10476
Entrez Gene 10476
HGNC 845
UniProt O75947  
 ATP5H identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for ATP5H
Molecular Function
    hydrogen ion transmembrane transporter activity GO:0015078 IEA
    ATPase activity GO:0016887 IDA
    transmembrane transporter activity GO:0022857 IC
Biological Process
    small molecule metabolic process GO:0044281 TAS
    respiratory electron transport chain GO:0022904 TAS
    mitochondrial ATP synthesis coupled proton transport GO:0042776 TAS
    cellular metabolic process GO:0044237 TAS
Subcellular Localization
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) GO:0000276 IEA
    nucleoplasm GO:0005654 IDA
    extracellular exosome GO:0070062 IDA
    mitochondrion GO:0005739 IDA
    cytoplasm GO:0005737 IDA
    mitochondrial proton-transporting ATP synthase complex GO:0005753 IDA
 Experiment description of studies that identified ATP5H in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ATP5H
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ATP5H is involved
PathwayEvidenceSource
Formation of ATP by chemiosmotic coupling TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here