Gene description for CISD3
Gene name CDGSH iron sulfur domain 3
Gene symbol CISD3
Other names/aliases Miner2
Species Homo sapiens
 Database cross references - CISD3
ExoCarta ExoCarta_284106
Vesiclepedia VP_284106
Entrez Gene 284106
HGNC 27578
MIM 611933
UniProt P0C7P0  
 CISD3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CISD3
Molecular Function
    metal ion binding GO:0046872 IDA
    2 iron, 2 sulfur cluster binding GO:0051537 IBA
    2 iron, 2 sulfur cluster binding GO:0051537 IDA
Biological Process
    protein maturation by [2Fe-2S] cluster transfer GO:0106034 IBA
    protein maturation by [2Fe-2S] cluster transfer GO:0106034 IDA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified CISD3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CISD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC16A1 6566
Affinity Capture-MS Homo sapiens
2 GLRX5 51218
Affinity Capture-MS Homo sapiens
3 CISD3 284106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 AFG3L2 10939
Affinity Capture-MS Homo sapiens
5 GLS 2744
Affinity Capture-MS Homo sapiens
6 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
7 TIMM50 92609
Affinity Capture-MS Homo sapiens
8 PMPCB 9512
Affinity Capture-MS Homo sapiens
9 CLPX 10845
Affinity Capture-MS Homo sapiens
10 NDUFS1 4719
Affinity Capture-MS Homo sapiens
11 MTERF3  
Affinity Capture-MS Homo sapiens
12 DHCR24 1718
Affinity Capture-MS Homo sapiens
13 TRMT10C 54931
Affinity Capture-MS Homo sapiens
14 PITRM1 10531
Affinity Capture-MS Homo sapiens
15 MTX1 4580
Affinity Capture-MS Homo sapiens
16 STOML2 30968
Affinity Capture-MS Homo sapiens
17 ADAM33 80332
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 ATP5H 10476
Affinity Capture-MS Homo sapiens
19 UQCRB 7381
Affinity Capture-MS Homo sapiens
20 HAVCR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 BCKDHA 593
Affinity Capture-MS Homo sapiens
22 ECH1 1891
Affinity Capture-MS Homo sapiens
23 ATP5F1 515
Affinity Capture-MS Homo sapiens
24 COX6A1  
Affinity Capture-MS Homo sapiens
25 SLC25A1 6576
Affinity Capture-MS Homo sapiens
26 DHX30 22907
Affinity Capture-MS Homo sapiens
27 NDUFS2 4720
Affinity Capture-MS Homo sapiens
28 NT5DC2 64943
Affinity Capture-MS Homo sapiens
29 COX6C 1345
Affinity Capture-MS Homo sapiens
30 IDE 3416
Affinity Capture-MS Homo sapiens
31 NDUFS3 4722
Affinity Capture-MS Homo sapiens
32 CHCHD4  
Affinity Capture-MS Homo sapiens
33 NIPSNAP1 8508
Affinity Capture-MS Homo sapiens
34 NDUFA2 4695
Affinity Capture-MS Homo sapiens
35 NCAPD3 23310
Affinity Capture-MS Homo sapiens
36 MYC  
Affinity Capture-MS Homo sapiens
37 ABCA6 23460
Affinity Capture-MS Homo sapiens
38 ATP5E 514
Affinity Capture-MS Homo sapiens
39 PMPCA 23203
Affinity Capture-MS Homo sapiens
40 SARS2 54938
Affinity Capture-MS Homo sapiens
41 MIPEP  
Affinity Capture-MS Homo sapiens
42 CHCHD2  
Affinity Capture-MS Homo sapiens
43 TARS2 80222
Affinity Capture-MS Homo sapiens
44 POLDIP2 26073
Affinity Capture-MS Homo sapiens
45 GRSF1 2926
Affinity Capture-MS Homo sapiens
46 MYCN  
Affinity Capture-MS Homo sapiens
47 YARS2  
Affinity Capture-MS Homo sapiens
48 S100B 6285
Affinity Capture-MS Homo sapiens
49 NDUFA5 4698
Affinity Capture-MS Homo sapiens
50 CACNG5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 CLPB 81570
Affinity Capture-MS Homo sapiens
52 MRPL22  
Affinity Capture-MS Homo sapiens
53 NDUFC2 4718
Affinity Capture-MS Homo sapiens
54 POLRMT 5442
Affinity Capture-MS Homo sapiens
55 ATP5O 539
Affinity Capture-MS Homo sapiens
56 SMOC1 64093
Affinity Capture-MS Homo sapiens
57 TOMM5  
Affinity Capture-MS Homo sapiens
58 TIMM44 10469
Affinity Capture-MS Homo sapiens
59 ERAL1  
Affinity Capture-MS Homo sapiens
60 SCO2  
Affinity Capture-MS Homo sapiens
61 LRFN4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CISD3 is involved
No pathways found





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