Gene description for ABCA6
Gene name ATP-binding cassette, sub-family A (ABC1), member 6
Gene symbol ABCA6
Other names/aliases EST155051
Species Homo sapiens
 Database cross references - ABCA6
ExoCarta ExoCarta_23460
Entrez Gene 23460
HGNC 36
MIM 612504
UniProt Q8N139  
 ABCA6 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ABCA6
Molecular Function
    ATPase activity, coupled to transmembrane movement of substances GO:0042626 IBA
    ATP binding GO:0005524 IEA
Biological Process
    lipid transport GO:0006869 IBA
    metabolic process GO:0008152 IEA
    transmembrane transport GO:0055085 IBA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    intracellular membrane-bounded organelle GO:0043231 IBA
 Experiment description of studies that identified ABCA6 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ABCA6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ABCA6 is involved
PathwayEvidenceSource
ABCA transporters in lipid homeostasis TAS Reactome





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