Gene description for ABCA6
Gene name ATP-binding cassette, sub-family A (ABC1), member 6
Gene symbol ABCA6
Other names/aliases EST155051
Species Homo sapiens
 Database cross references - ABCA6
ExoCarta ExoCarta_23460
Vesiclepedia VP_23460
Entrez Gene 23460
HGNC 36
MIM 612504
UniProt Q8N139  
 ABCA6 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ABCA6
Molecular Function
    lipid transporter activity GO:0005319 IBA
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
    ATPase-coupled transmembrane transporter activity GO:0042626 IBA
    ABC-type transporter activity GO:0140359 IEA
Biological Process
    lipid transport GO:0006869 IBA
    transmembrane transport GO:0055085 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IDA
    nucleoplasm GO:0005654 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    intracellular membrane-bounded organelle GO:0043231 IBA
 Experiment description of studies that identified ABCA6 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ABCA6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CISD3 284106
Affinity Capture-MS Homo sapiens
2 ABCA2 20
Affinity Capture-MS Homo sapiens
3 ANKLE2 23141
Affinity Capture-MS Homo sapiens
4 APOA1 335
Affinity Capture-MS Homo sapiens
5 DNAJC30  
Affinity Capture-MS Homo sapiens
6 ABCA10  
Affinity Capture-MS Homo sapiens
7 STX6 10228
Affinity Capture-MS Homo sapiens
8 ABCA8 10351
Affinity Capture-MS Homo sapiens
9 FADS1 3992
Affinity Capture-MS Homo sapiens
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