Gene description for ABCA8
Gene name ATP-binding cassette, sub-family A (ABC1), member 8
Gene symbol ABCA8
Other names/aliases -
Species Homo sapiens
 Database cross references - ABCA8
ExoCarta ExoCarta_10351
Vesiclepedia VP_10351
Entrez Gene 10351
HGNC 38
MIM 612505
UniProt O94911  
 ABCA8 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ABCA8
Molecular Function
    lipid transporter activity GO:0005319 IBA
    ATP binding GO:0005524 IEA
    ABC-type xenobiotic transporter activity GO:0008559 IDA
    ABC-type xenobiotic transporter activity GO:0008559 IMP
    ATP hydrolysis activity GO:0016887 IEA
    ATPase-coupled transmembrane transporter activity GO:0042626 IBA
    ATPase-coupled transmembrane transporter activity GO:0042626 TAS
    ABC-type transporter activity GO:0140359 IMP
    ABC-type transporter activity GO:0140359 ISS
Biological Process
    sphingomyelin biosynthetic process GO:0006686 IMP
    xenobiotic transmembrane transport GO:0006855 IDA
    lipid transport GO:0006869 IBA
    regulation of cholesterol efflux GO:0010874 IMP
    positive regulation of cholesterol efflux GO:0010875 IMP
    cholesterol transport GO:0030301 IMP
    cholesterol transport GO:0030301 ISS
    cholesterol efflux GO:0033344 IMP
    cholesterol efflux GO:0033344 ISS
    xenobiotic transport GO:0042908 IMP
    transmembrane transport GO:0055085 IEA
    transmembrane transport GO:0055085 TAS
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    basolateral plasma membrane GO:0016323 ISS
    intracellular membrane-bounded organelle GO:0043231 IBA
 Experiment description of studies that identified ABCA8 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ABCA8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BRD1 23774
Affinity Capture-MS Homo sapiens
2 AMY1C 278
Affinity Capture-MS Homo sapiens
3 CST2  
Affinity Capture-MS Homo sapiens
4 CST4 1472
Affinity Capture-MS Homo sapiens
5 ABCA6 23460
Affinity Capture-MS Homo sapiens
6 VCP 7415
Cross-Linking-MS (XL-MS) Homo sapiens
7 SARNP 84324
Cross-Linking-MS (XL-MS) Homo sapiens
8 SUMO2 6613
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which ABCA8 is involved
PathwayEvidenceSource
ABC-family proteins mediated transport TAS Reactome
Transport of small molecules TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here