Gene description for SMOC1
Gene name SPARC related modular calcium binding 1
Gene symbol SMOC1
Other names/aliases OAS
Species Homo sapiens
 Database cross references - SMOC1
ExoCarta ExoCarta_64093
Vesiclepedia VP_64093
Entrez Gene 64093
HGNC 20318
MIM 608488
UniProt Q9H4F8  
 SMOC1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for SMOC1
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IBA
    extracellular matrix binding GO:0050840 IBA
Biological Process
    eye development GO:0001654 IMP
    cell differentiation GO:0030154 IEA
    extracellular matrix organization GO:0030198 IBA
    regulation of osteoblast differentiation GO:0045667 IMP
    limb development GO:0060173 IMP
Subcellular Localization
    basement membrane GO:0005604 IBA
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified SMOC1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SMOC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBR2 23304
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 CISD3 284106
Affinity Capture-MS Homo sapiens
4 NOTCH2NL 388677
Two-hybrid Homo sapiens
5 DKK3 27122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 NR4A3  
Two-hybrid Homo sapiens
7 RETNLB  
Affinity Capture-MS Homo sapiens
8 DEFA1 1667
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TCTN1  
Affinity Capture-MS Homo sapiens
10 NOTCH2 4853
Affinity Capture-MS Homo sapiens
11 CTH 1491
Affinity Capture-MS Homo sapiens
12 SMOC2 64094
Reconstituted Complex Homo sapiens
13 TNFSF8  
Affinity Capture-MS Homo sapiens
14 TAZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 KRTAP10-8  
Two-hybrid Homo sapiens
16 PON2 5445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 NME2 4831
Affinity Capture-MS Homo sapiens
18 IGFBP1  
Affinity Capture-MS Homo sapiens
19 KRTAP1-1  
Two-hybrid Homo sapiens
20 KRTAP10-3  
Two-hybrid Homo sapiens
21 SLURP1  
Affinity Capture-MS Homo sapiens
22 FEM1B 10116
Affinity Capture-MS Homo sapiens
23 NAF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CORO1C 23603
Co-fractionation Homo sapiens
25 PNN 5411
Affinity Capture-MS Homo sapiens
26 Hoxa1  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
27 EPHA7 2045
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 LRP1 4035
Affinity Capture-MS Homo sapiens
29 HSP90AA4P 3323
Affinity Capture-MS Homo sapiens
30 TCF4  
Two-hybrid Homo sapiens
31 RNPS1 10921
Affinity Capture-MS Homo sapiens
32 TRMU  
Affinity Capture-MS Homo sapiens
33 VGLL3  
Two-hybrid Homo sapiens
34 CYSRT1 375791
Two-hybrid Homo sapiens
35 AFF4 27125
Affinity Capture-MS Homo sapiens
36 PAPSS1 9061
Affinity Capture-MS Homo sapiens
37 TMED7 51014
Affinity Capture-MS Homo sapiens
38 FAM115C  
Affinity Capture-MS Homo sapiens
39 DCAF16 54876
Affinity Capture-MS Homo sapiens
40 GINM1 116254
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 MLLT3 4300
Affinity Capture-MS Homo sapiens
42 ITGA9 3680
Affinity Capture-MS Homo sapiens
43 PATE1  
Affinity Capture-MS Homo sapiens
44 FBLN5 10516
Affinity Capture-MS Homo sapiens
45 ST14 6768
Affinity Capture-MS Homo sapiens
46 PRSS21  
Affinity Capture-MS Homo sapiens
47 SMOC1 64093
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
48 DNAJB11 51726
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which SMOC1 is involved
No pathways found





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