Gene description for UBR2
Gene name ubiquitin protein ligase E3 component n-recognin 2
Gene symbol UBR2
Other names/aliases C6orf133
bA49A4.1
dJ242G1.1
dJ392M17.3
Species Homo sapiens
 Database cross references - UBR2
ExoCarta ExoCarta_23304
Vesiclepedia VP_23304
Entrez Gene 23304
HGNC 21289
MIM 609134
UniProt Q8IWV8  
 UBR2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for UBR2
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IDA
    L-leucine binding GO:0070728 IDA
    histone H2A ubiquitin ligase activity GO:0141053 ISS
Biological Process
    reciprocal meiotic recombination GO:0007131 ISS
    male meiotic nuclear division GO:0007140 ISS
    male meiosis I GO:0007141 IEA
    spermatogenesis GO:0007283 ISS
    transposable element silencing GO:0010526 ISS
    protein ubiquitination GO:0016567 IBA
    heterochromatin formation GO:0031507 ISS
    negative regulation of TOR signaling GO:0032007 IMP
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA
    positive regulation of T cell receptor signaling pathway GO:0050862 IDA
    protein K63-linked ubiquitination GO:0070534 IDA
    cellular response to L-leucine GO:0071233 IDA
    ubiquitin-dependent protein catabolic process via the N-end rule pathway GO:0071596 IBA
    ubiquitin-dependent protein catabolic process via the N-end rule pathway GO:0071596 IDA
Subcellular Localization
    ubiquitin ligase complex GO:0000151 IBA
    chromatin GO:0000785 IEA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IC
    cytosol GO:0005829 TAS
 Experiment description of studies that identified UBR2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UBR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Reconstituted Complex Homo sapiens
2 GCFC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 UBE2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
4 HOXA7  
Affinity Capture-MS Homo sapiens
5 YWHAE 7531
Affinity Capture-MS Homo sapiens
6 HIST1H2BG 8339
Biochemical Activity Homo sapiens
7 CFC1  
Affinity Capture-MS Homo sapiens
8 GFAP 2670
Affinity Capture-MS Homo sapiens
9 CRHBP  
Affinity Capture-MS Homo sapiens
10 NUDT6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 UBC 7316
Affinity Capture-MS Homo sapiens
12 MRPL50 54534
Affinity Capture-MS Homo sapiens
13 IGFBP4 3487
Affinity Capture-MS Homo sapiens
14 HEPACAM2  
Affinity Capture-MS Homo sapiens
15 HYAL1 3373
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 C1orf87  
Affinity Capture-MS Homo sapiens
17 NDUFS3 4722
Affinity Capture-MS Homo sapiens
18 SULF2 55959
Affinity Capture-MS Homo sapiens
19 TGFB1 7040
Affinity Capture-MS Homo sapiens
20 UBE2O 63893
Affinity Capture-Western Homo sapiens
21 Ttll7  
Affinity Capture-MS Mus musculus
22 RECQL4  
Affinity Capture-MS Homo sapiens
23 PSMC2 5701
Co-fractionation Homo sapiens
24 SMOC1 64093
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 IGF2 3481
Affinity Capture-MS Homo sapiens
26 HIST2H2AC 8338
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
27 TEX19  
Affinity Capture-MS Homo sapiens
28 Naa11  
Affinity Capture-MS Mus musculus
29 CCDC130  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 POLR2M  
Affinity Capture-MS Homo sapiens
31 FAF2 23197
Affinity Capture-MS Homo sapiens
32 METTL2A  
Affinity Capture-MS Homo sapiens
33 PMEPA1 56937
Affinity Capture-MS Homo sapiens
34 PAM 5066
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 IL25  
Affinity Capture-MS Homo sapiens
36 CHRDL2 25884
Affinity Capture-MS Homo sapiens
37 BAG6 7917
Affinity Capture-MS Homo sapiens
38 ALDH18A1 5832
Affinity Capture-MS Homo sapiens
39 IBSP  
Affinity Capture-MS Homo sapiens
40 CLCC1 23155
Affinity Capture-MS Homo sapiens
41 NXPH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 NUDT16 131870
Affinity Capture-MS Homo sapiens
43 PDP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 DEFB110  
Affinity Capture-MS Homo sapiens
45 PLXDC2 84898
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 PLEKHO2 80301
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 SRY  
Affinity Capture-MS Homo sapiens
48 TDGF1  
Affinity Capture-MS Homo sapiens
49 WNT10A  
Affinity Capture-MS Homo sapiens
50 PAK7  
Affinity Capture-MS Homo sapiens
51 RGS8  
Affinity Capture-MS Homo sapiens
52 FOXJ3  
Affinity Capture-MS Homo sapiens
53 PARD6B 84612
Affinity Capture-MS Homo sapiens
54 TIRAP  
Affinity Capture-MS Homo sapiens
55 EPPK1 83481
Affinity Capture-MS Homo sapiens
56 LYPD6B 130576
Affinity Capture-MS Homo sapiens
57 MRM1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 HLA-DPB1 3115
Affinity Capture-MS Homo sapiens
59 DKK4  
Affinity Capture-MS Homo sapiens
60 WBSCR16  
Affinity Capture-MS Homo sapiens
61 DUSP26 78986
Affinity Capture-MS Homo sapiens
62 MRPS11  
Affinity Capture-MS Homo sapiens
63 UBXN7 26043
Affinity Capture-MS Homo sapiens
64 PON2 5445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 UBE2Z 65264
Affinity Capture-Western Homo sapiens
66 HS3ST2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 ASB6 140459
Affinity Capture-MS Homo sapiens
68 SPC24 147841
Affinity Capture-MS Homo sapiens
69 SNX18 112574
Affinity Capture-MS Homo sapiens
70 SGOL1  
Affinity Capture-MS Homo sapiens
71 GADD45GIP1  
Affinity Capture-MS Homo sapiens
72 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
73 INSL5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 INS 3630
Affinity Capture-MS Homo sapiens
75 EPHA7 2045
Affinity Capture-MS Homo sapiens
76 UBE2D2 7322
Reconstituted Complex Homo sapiens
77 MYC  
Affinity Capture-MS Homo sapiens
78 CROCC 9696
Affinity Capture-MS Homo sapiens
79 NOG 9241
Affinity Capture-MS Homo sapiens
80 METTL15  
Affinity Capture-MS Homo sapiens
81 UBXN2B  
Affinity Capture-MS Homo sapiens
82 UBXN1 51035
Affinity Capture-MS Homo sapiens
83 Dynlrb1 67068
Affinity Capture-MS Mus musculus
84 ZRANB1 54764
Affinity Capture-MS Homo sapiens
85 NES 10763
Affinity Capture-MS Homo sapiens
86 NRP1 8829
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 SPCS3 60559
Affinity Capture-MS Homo sapiens
88 CA6 765
Affinity Capture-MS Homo sapiens
89 SOD2 6648
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 SPINK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 CLEC2D  
Affinity Capture-MS Homo sapiens
92 PNLIPRP1  
Affinity Capture-MS Homo sapiens
93 SIL1 64374
Affinity Capture-MS Homo sapiens
94 CELA3B  
Affinity Capture-MS Homo sapiens
95 UBE2B 7320
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
96 FAF1 11124
Affinity Capture-MS Homo sapiens
97 GH2  
Affinity Capture-MS Homo sapiens
98 ATXN3 4287
Affinity Capture-MS Homo sapiens
99 TEX33  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 PLIN2 123
Affinity Capture-Western Homo sapiens
101 Cdc26  
Affinity Capture-MS Mus musculus
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