Gene description for CLCC1
Gene name chloride channel CLIC-like 1
Gene symbol CLCC1
Other names/aliases MCLC
Species Homo sapiens
 Database cross references - CLCC1
ExoCarta ExoCarta_23155
Vesiclepedia VP_23155
Entrez Gene 23155
HGNC 29675
UniProt Q96S66  
 CLCC1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CLCC1
Molecular Function
    chloride channel activity GO:0005254 IBA
    chloride channel activity GO:0005254 IDA
    protein binding GO:0005515 IPI
Biological Process
    endoplasmic reticulum calcium ion homeostasis GO:0032469 IMP
    chloride transmembrane transport GO:1902476 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    membrane GO:0016020 HDA
    chloride channel complex GO:0034707 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 IDA
 Experiment description of studies that identified CLCC1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CLCC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTPRG 5793
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 HSD17B11 51170
Proximity Label-MS Homo sapiens
4 TMBIM6 7009
Affinity Capture-MS Homo sapiens
5 METTL7A 25840
Proximity Label-MS Homo sapiens
6 LAMP3  
Proximity Label-MS Homo sapiens
7 ATG9A 79065
Proximity Label-MS Homo sapiens
8 GJA1 2697
Proximity Label-MS Homo sapiens
9 RNASE13  
Affinity Capture-MS Homo sapiens
10 C9orf78 51759
Affinity Capture-MS Homo sapiens
11 GJD3  
Proximity Label-MS Homo sapiens
12 LAMP2 3920
Proximity Label-MS Homo sapiens
13 DNAJC25 548645
Proximity Label-MS Homo sapiens
14 PTPN1 5770
Proximity Label-MS Homo sapiens
15 STX4 6810
Proximity Label-MS Homo sapiens
16 TMA16  
Affinity Capture-MS Homo sapiens
17 FIS1 51024
Proximity Label-MS Homo sapiens
18 DYNC1LI2 1783
Proximity Label-MS Homo sapiens
19 RAB3B 5865
Proximity Label-MS Homo sapiens
20 STX7 8417
Proximity Label-MS Homo sapiens
21 SSR1 6745
Proximity Label-MS Homo sapiens
22 MARCH5  
Proximity Label-MS Homo sapiens
23 AGTR1  
Affinity Capture-MS Homo sapiens
24 TTYH1  
Affinity Capture-MS Homo sapiens
25 DNAJC16  
Proximity Label-MS Homo sapiens
26 SLC25A46 91137
Proximity Label-MS Homo sapiens
27 RAB35 11021
Proximity Label-MS Homo sapiens
28 MARCKS 4082
Proximity Label-MS Homo sapiens
29 LMAN1 3998
Proximity Label-MS Homo sapiens
30 NUP155 9631
Proximity Label-MS Homo sapiens
31 KIAA1715 80856
Proximity Label-MS Homo sapiens
32 PXMP2  
Proximity Label-MS Homo sapiens
33 LRRC59 55379
Proximity Label-MS Homo sapiens
34 NF2 4771
Affinity Capture-MS Homo sapiens
35 PTPRN2  
Proximity Label-MS Homo sapiens
36 COX15 1355
Affinity Capture-MS Homo sapiens
37 PLSCR1 5359
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 EMD 2010
Proximity Label-MS Homo sapiens
39 CXADR 1525
Proximity Label-MS Homo sapiens
40 SPNS3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 RAB4A 5867
Proximity Label-MS Homo sapiens
42 ARHGEF1 9138
Affinity Capture-MS Homo sapiens
43 DAZAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 ACACA 31
Negative Genetic Homo sapiens
45 COMTD1 118881
Affinity Capture-MS Homo sapiens
46 OGT 8473
Reconstituted Complex Homo sapiens
47 STX6 10228
Proximity Label-MS Homo sapiens
48 RPN1 6184
Proximity Label-MS Homo sapiens
49 PSMA5 5686
Affinity Capture-MS Homo sapiens
50 DNAJC30  
Proximity Label-MS Homo sapiens
51 RHOT2 89941
Proximity Label-MS Homo sapiens
52 ELOVL5 60481
Proximity Label-MS Homo sapiens
53 SEC61B 10952
Proximity Label-MS Homo sapiens
54 DNAJB11 51726
Proximity Label-MS Homo sapiens
55 ZACN  
Affinity Capture-MS Homo sapiens
56 RMDN3 55177
Proximity Label-MS Homo sapiens
57 UBR2 23304
Affinity Capture-MS Homo sapiens
58 REEP5 7905
Proximity Label-MS Homo sapiens
59 SEC63 11231
Proximity Label-MS Homo sapiens
60 TMEM30A 55754
Affinity Capture-MS Homo sapiens
61 RPN2 6185
Proximity Label-MS Homo sapiens
62 CANX 821
Affinity Capture-MS Homo sapiens
63 DNAJB12 54788
Proximity Label-MS Homo sapiens
64 CALR3  
Proximity Label-MS Homo sapiens
65 PANX1 24145
Proximity Label-MS Homo sapiens
66 TBCE 6905
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 LAMP1 3916
Proximity Label-MS Homo sapiens
68 BCAP31 10134
Proximity Label-MS Homo sapiens
69 HSD3B7 80270
Proximity Label-MS Homo sapiens
70 CUL3 8452
Affinity Capture-MS Homo sapiens
71 STIM1 6786
Proximity Label-MS Homo sapiens
72 FKBP8 23770
Proximity Label-MS Homo sapiens
73 ARF6 382
Proximity Label-MS Homo sapiens
74 OCIAD1 54940
Proximity Label-MS Homo sapiens
75 PRKACA 5566
Proximity Label-MS Homo sapiens
76 UBR1 197131
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 ATP2A1 487
Proximity Label-MS Homo sapiens
78 RAB9A 9367
Proximity Label-MS Homo sapiens
79 DNAJC3 5611
Proximity Label-MS Homo sapiens
80 DHFRL1  
Proximity Label-MS Homo sapiens
81 VDAC1 7416
Affinity Capture-MS Homo sapiens
82 CYP2C9  
Proximity Label-MS Homo sapiens
83 HAX1  
Proximity Label-MS Homo sapiens
84 GMCL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 AMTN  
Affinity Capture-MS Homo sapiens
86 C17orf80 55028
Proximity Label-MS Homo sapiens
87 FASN 2194
Negative Genetic Homo sapiens
88 GABRE  
Affinity Capture-MS Homo sapiens
89 SEMA7A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 PDIA4 9601
Proximity Label-MS Homo sapiens
91 CALU 813
Proximity Label-MS Homo sapiens
92 TPTE  
Proximity Label-MS Homo sapiens
93 TSPAN15 23555
Affinity Capture-MS Homo sapiens
94 ERGIC1 57222
Proximity Label-MS Homo sapiens
95 DDX58 23586
Affinity Capture-RNA Homo sapiens
96 ZNF684  
Affinity Capture-MS Homo sapiens
97 RAB5A 5868
Proximity Label-MS Homo sapiens
98 ERGIC2 51290
Proximity Label-MS Homo sapiens
99 PLD3 23646
Affinity Capture-MS Homo sapiens
100 SPCS1 28972
Affinity Capture-MS Homo sapiens
101 SEC62 7095
Proximity Label-MS Homo sapiens
102 B3GAT1  
Proximity Label-MS Homo sapiens
103 RAB7A 7879
Proximity Label-MS Homo sapiens
104 RAB11A 8766
Proximity Label-MS Homo sapiens
105 DNAJC1 64215
Proximity Label-MS Homo sapiens
106 KRAS 3845
Proximity Label-MS Homo sapiens
107 RAB5C 5878
Proximity Label-MS Homo sapiens
108 CCDC47 57003
Affinity Capture-MS Homo sapiens
109 CKAP4 10970
Proximity Label-MS Homo sapiens
110 VAV3 10451
Affinity Capture-MS Homo sapiens
111 DERL1 79139
Proximity Label-MS Homo sapiens
112 DNAJC22  
Proximity Label-MS Homo sapiens
113 Klhl22  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which CLCC1 is involved
No pathways found





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