Gene description for PTPN1
Gene name protein tyrosine phosphatase, non-receptor type 1
Gene symbol PTPN1
Other names/aliases PTP1B
Species Homo sapiens
 Database cross references - PTPN1
ExoCarta ExoCarta_5770
Vesiclepedia VP_5770
Entrez Gene 5770
HGNC 9642
MIM 176885
UniProt P18031  
 PTPN1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Squamous carcinoma cells 20124223    
T lymphocytes 34108659    
Thymus 23844026    
 Gene ontology annotations for PTPN1
Molecular Function
    RNA binding GO:0003723 HDA
    protein tyrosine phosphatase activity GO:0004725 IDA
    protein tyrosine phosphatase activity GO:0004725 TAS
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IBA
    insulin receptor binding GO:0005158 IEA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IDA
    enzyme binding GO:0019899 IPI
    protein kinase binding GO:0019901 IBA
    protein kinase binding GO:0019901 IPI
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    receptor tyrosine kinase binding GO:0030971 IPI
    cadherin binding GO:0045296 HDA
    ephrin receptor binding GO:0046875 IPI
    protein phosphatase 2A binding GO:0051721 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
Biological Process
    positive regulation of systemic arterial blood pressure GO:0003084 IEA
    chromatin remodeling GO:0006338 IEA
    protein dephosphorylation GO:0006470 IMP
    negative regulation of cell population proliferation GO:0008285 IEA
    insulin receptor signaling pathway GO:0008286 IEA
    regulation of signal transduction GO:0009966 IMP
    negative regulation of signal transduction GO:0009968 TAS
    positive regulation of heart rate GO:0010460 IEA
    positive regulation of cardiac muscle cell apoptotic process GO:0010666 IEA
    negative regulation of cell-substrate adhesion GO:0010812 IEA
    negative regulation of neuron projection development GO:0010977 IEA
    actin cytoskeleton organization GO:0030036 IMP
    regulation of endocytosis GO:0030100 IDA
    regulation of proteolysis GO:0030162 IEA
    negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 ISS
    endoplasmic reticulum unfolded protein response GO:0030968 IDA
    response to nutrient levels GO:0031667 IEA
    regulation of intracellular protein transport GO:0033157 IMP
    cellular response to unfolded protein GO:0034620 TAS
    peptidyl-tyrosine dephosphorylation GO:0035335 IDA
    peptidyl-tyrosine dephosphorylation GO:0035335 IMP
    platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IMP
    cellular response to platelet-derived growth factor stimulus GO:0036120 IEA
    IRE1-mediated unfolded protein response GO:0036498 ISS
    insulin receptor recycling GO:0038020 IEA
    negative regulation of MAP kinase activity GO:0043407 IMP
    positive regulation of JUN kinase activity GO:0043507 ISS
    cellular response to fibroblast growth factor stimulus GO:0044344 IEA
    negative regulation of insulin receptor signaling pathway GO:0046627 NAS
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IEA
    regulation of type I interferon-mediated signaling pathway GO:0060338 TAS
    growth hormone receptor signaling pathway via JAK-STAT GO:0060397 TAS
    positive regulation of protein tyrosine kinase activity GO:0061098 IDA
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IBA
    negative regulation of ERK1 and ERK2 cascade GO:0070373 ISS
    cellular response to hypoxia GO:0071456 IEA
    cellular response to nitric oxide GO:0071732 IEA
    regulation of postsynapse assembly GO:0150052 IEA
    regulation of hepatocyte growth factor receptor signaling pathway GO:1902202 IMP
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 ISS
    positive regulation of IRE1-mediated unfolded protein response GO:1903896 TAS
    negative regulation of PERK-mediated unfolded protein response GO:1903898 IBA
    negative regulation of PERK-mediated unfolded protein response GO:1903898 IDA
    cellular response to angiotensin GO:1904385 IEA
    negative regulation of vascular associated smooth muscle cell migration GO:1904753 IEA
    cellular response to nerve growth factor stimulus GO:1990090 IEA
    peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity GO:1990264 ISS
    positive regulation of endothelial cell apoptotic process GO:2000353 IEA
    positive regulation of receptor catabolic process GO:2000646 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
    mitochondrial matrix GO:0005759 IEA
    early endosome GO:0005769 IBA
    early endosome GO:0005769 IDA
    early endosome GO:0005769 ISS
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    mitochondrial crista GO:0030061 IEA
    endosome lumen GO:0031904 IEA
    protein-containing complex GO:0032991 IDA
    sorting endosome GO:0097443 ISS
    cytoplasmic side of endoplasmic reticulum membrane GO:0098554 IDA
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified PTPN1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
12
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
17
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
21
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
22
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
23
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
24
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
25
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
28
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
29
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
30
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
31
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
32
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
33
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
34
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
35
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
36
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
37
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
38
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PTPN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Proximity Label-MS Homo sapiens
2 ITGB1 3688
Proximity Label-MS Homo sapiens
3 SLC39A12  
Affinity Capture-MS Homo sapiens
4 GJD3  
Proximity Label-MS Homo sapiens
5 ARHGAP1 392
Proximity Label-MS Homo sapiens
6 PPP1CB 5500
Co-fractionation Homo sapiens
7 STAT5B 6777
Protein-peptide Homo sapiens
8 ATG9A 79065
Proximity Label-MS Homo sapiens
9 SRPRB 58477
Proximity Label-MS Homo sapiens
10 DYNC1I2 1781
Co-fractionation Homo sapiens
11 CRK 1398
Reconstituted Complex Homo sapiens
12 JPH1 56704
Proximity Label-MS Homo sapiens
13 PISD  
Affinity Capture-MS Homo sapiens
14 MID1 4281
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 SMARCD2 6603
Affinity Capture-MS Homo sapiens
16 TACC2 10579
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
17 TMEM179B 374395
Affinity Capture-MS Homo sapiens
18 PTRH2 51651
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
19 COL5A1 1289
Affinity Capture-MS Homo sapiens
20 OSBPL9 114883
Proximity Label-MS Homo sapiens
21 SMPD4 55627
Proximity Label-MS Homo sapiens
22 ABCD3 5825
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
23 FBL 2091
Proximity Label-MS Homo sapiens
24 MARCH5  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
25 VPS13D 55187
Proximity Label-MS Homo sapiens
26 LAMTOR3 8649
Co-fractionation Homo sapiens
27 MARCKSL1 65108
Co-fractionation Homo sapiens
28 SLC25A46 91137
Proximity Label-MS Homo sapiens
29 CYP2C9  
Proximity Label-MS Homo sapiens
30 SLC25A3 5250
Co-fractionation Homo sapiens
31 KIF14 9928
Affinity Capture-MS Homo sapiens
32 EMC1 23065
Proximity Label-MS Homo sapiens
33 CAMLG 819
Proximity Label-MS Homo sapiens
34 GOLIM4 27333
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 FAM96A  
Affinity Capture-MS Homo sapiens
36 MTCH2 23788
Proximity Label-MS Homo sapiens
37 SENP2 59343
Proximity Label-MS Homo sapiens
38 NAPA 8775
Co-fractionation Homo sapiens
39 CAPZA1 829
Co-fractionation Homo sapiens
40 TMX1 81542
Proximity Label-MS Homo sapiens
41 ILVBL 10994
Affinity Capture-MS Homo sapiens
42 PPIH 10465
Co-fractionation Homo sapiens
43 AKAP1 8165
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
44 NTRK3 4916
Protein-peptide Homo sapiens
45 CDH1 999
Proximity Label-MS Homo sapiens
46 CLCC1 23155
Proximity Label-MS Homo sapiens
47 TYK2 7297
Affinity Capture-Western Homo sapiens
48 UBXN4 23190
Proximity Label-MS Homo sapiens
49 PEX14 5195
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
50 LYPD6  
Affinity Capture-MS Homo sapiens
51 CUL2 8453
Co-fractionation Homo sapiens
52 AHCTF1 25909
Proximity Label-MS Homo sapiens
53 SND1 27044
Proximity Label-MS Homo sapiens
54 SEC61B 10952
Proximity Label-MS Homo sapiens
55 REEP5 7905
Proximity Label-MS Homo sapiens
56 ANLN 54443
Affinity Capture-MS Homo sapiens
57 TRIP13 9319
Affinity Capture-MS Homo sapiens
58 RNF40 9810
Co-fractionation Homo sapiens
59 DHCR7 1717
Affinity Capture-MS Homo sapiens
60 LMNB1 4001
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
61 ZC3HAV1 56829
Proximity Label-MS Homo sapiens
62 ZNF622 90441
Proximity Label-MS Homo sapiens
63 GGH 8836
Affinity Capture-MS Homo sapiens
64 CD274 29126
Affinity Capture-MS Homo sapiens
65 BCAP31 10134
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
66 TMEM199  
Proximity Label-MS Homo sapiens
67 ASS1 445
Two-hybrid Homo sapiens
68 SYT6  
Affinity Capture-MS Homo sapiens
69 FKBP8 23770
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
70 MYO19  
Proximity Label-MS Homo sapiens
71 AAAS 8086
Proximity Label-MS Homo sapiens
72 TCTN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 KIAA1467 57613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 SNX19  
Proximity Label-MS Homo sapiens
75 TMEM86B  
Two-hybrid Homo sapiens
76 PLTP 5360
Affinity Capture-MS Homo sapiens
77 ZW10 9183
Proximity Label-MS Homo sapiens
78 SOAT1 6646
Proximity Label-MS Homo sapiens
79 RPA3 6119
Proximity Label-MS Homo sapiens
80 TMCO1 54499
Proximity Label-MS Homo sapiens
81 RINT1 60561
Proximity Label-MS Homo sapiens
82 CCT8 10694
Co-fractionation Homo sapiens
83 RPL35A 6165
Affinity Capture-MS Homo sapiens
84 PSMC5 5705
Co-fractionation Homo sapiens
85 FAM169A  
Proximity Label-MS Homo sapiens
86 ENTPD2 954
Affinity Capture-MS Homo sapiens
87 STX4 6810
Proximity Label-MS Homo sapiens
88 TMEM214 54867
Proximity Label-MS Homo sapiens
89 ATP6V0A1 535
Affinity Capture-MS Homo sapiens
90 CSDE1 7812
Co-fractionation Homo sapiens
91 KIDINS220 57498
Affinity Capture-MS Homo sapiens
92 PEX3 8504
Proximity Label-MS Homo sapiens
93 FASN 2194
Co-fractionation Homo sapiens
94 TMEM57  
Proximity Label-MS Homo sapiens
95 GRB2 2885
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
96 AGPAT9  
Proximity Label-MS Homo sapiens
97 RGPD8  
Proximity Label-MS Homo sapiens
98 PCMT1 5110
Affinity Capture-MS Homo sapiens
99 EMC7 56851
Proximity Label-MS Homo sapiens
100 IL1B  
Affinity Capture-Western Homo sapiens
101 EMC4 51234
Proximity Label-MS Homo sapiens
102 WRAP53  
Affinity Capture-MS Homo sapiens
103 HSD3B7 80270
Proximity Label-MS Homo sapiens
104 ITPR3 3710
Proximity Label-MS Homo sapiens
105 C19orf25  
Proximity Label-MS Homo sapiens
106 WIF1 11197
Affinity Capture-MS Homo sapiens
107 DYNC1H1 1778
Co-fractionation Homo sapiens
108 RABL3 285282
Proximity Label-MS Homo sapiens
109 HM13 81502
Proximity Label-MS Homo sapiens
110 PSMA5 5686
Co-fractionation Homo sapiens
111 NDC1 55706
Proximity Label-MS Homo sapiens
112 CDK4 1019
Affinity Capture-MS Homo sapiens
113 RAB11A 8766
Proximity Label-MS Homo sapiens
114 CISD2 493856
Proximity Label-MS Homo sapiens
115 RAB5C 5878
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 NTRK2 4915
Protein-peptide Homo sapiens
117 ACBD3 64746
Proximity Label-MS Homo sapiens
118 ASB14  
Affinity Capture-MS Homo sapiens
119 SEC61A1 29927
Affinity Capture-MS Homo sapiens
120 C5AR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 NCBP1 4686
Co-fractionation Homo sapiens
122 ATL1 51062
Proximity Label-MS Homo sapiens
123 ARHGAP39  
Affinity Capture-MS Homo sapiens
124 METTL7A 25840
Proximity Label-MS Homo sapiens
125 LAMP3  
Proximity Label-MS Homo sapiens
126 SLC39A4 55630
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 GJA1 2697
Proximity Label-MS Homo sapiens
128 ARL6IP5 10550
Proximity Label-MS Homo sapiens
129 INSR 3643
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
130 NTNG1  
Affinity Capture-MS Homo sapiens
131 GOSR2 9570
Proximity Label-MS Homo sapiens
132 GPR114  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 COPA 1314
Proximity Label-MS Homo sapiens
134 PTPN2 5771
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
135 NUP160 23279
Proximity Label-MS Homo sapiens
136 DNAJB6 10049
Affinity Capture-MS Homo sapiens
137 GOLGA7 51125
Affinity Capture-MS Homo sapiens
138 VANGL2  
Proximity Label-MS Homo sapiens
139 PAAF1 80227
Co-fractionation Homo sapiens
140 FIS1 51024
Proximity Label-MS Homo sapiens
141 INSRR 3645
Affinity Capture-MS Homo sapiens
142 CHP1 11261
Proximity Label-MS Homo sapiens
143 NARS 4677
Affinity Capture-MS Homo sapiens
144 TBC1D15 64786
Affinity Capture-MS Homo sapiens
145 PHB 5245
Affinity Capture-MS Homo sapiens
146 PSMB6 5694
Co-fractionation Homo sapiens
147 PFN2 5217
Affinity Capture-MS Homo sapiens
148 TSN 7247
Co-fractionation Homo sapiens
149 HK1 3098
Proximity Label-MS Homo sapiens
150 GSK3B 2932
Biochemical Activity Homo sapiens
151 TDRKH  
Proximity Label-MS Homo sapiens
152 LMAN1 3998
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
153 PDZD8 118987
Proximity Label-MS Homo sapiens
154 KIAA1715 80856
Proximity Label-MS Homo sapiens
155 STAM2 10254
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
156 PCNP 57092
Affinity Capture-MS Homo sapiens
157 CHMP7 91782
Proximity Label-MS Homo sapiens
158 KLC1 3831
Co-fractionation Homo sapiens
159 STOM 2040
Affinity Capture-MS Homo sapiens
160 SNAP47 116841
Proximity Label-MS Homo sapiens
161 MTX2 10651
Proximity Label-MS Homo sapiens
162 RNF213 57674
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
163 CDKAL1  
Proximity Label-MS Homo sapiens
164 TRPM7 54822
Proximity Label-MS Homo sapiens
165 LAMP1 3916
Proximity Label-MS Homo sapiens
166 GK  
Proximity Label-MS Homo sapiens
167 PREB 10113
Proximity Label-MS Homo sapiens
168 TMEM63A 9725
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 ATP4A 495
Affinity Capture-MS Homo sapiens
170 STX5 6811
Proximity Label-MS Homo sapiens
171 TMEM131  
Proximity Label-MS Homo sapiens
172 MRAP2  
Affinity Capture-MS Homo sapiens
173 CXADR 1525
Proximity Label-MS Homo sapiens
174 CDIPT 10423
Affinity Capture-MS Homo sapiens
175 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
176 RPN2 6185
Proximity Label-MS Homo sapiens
177 AIFM1 9131
Proximity Label-MS Homo sapiens
178 CANX 821
Proximity Label-MS Homo sapiens
179 FLNA 2316
Co-fractionation Homo sapiens
180 TMPO 7112
Proximity Label-MS Homo sapiens
181 EMC8 10328
Proximity Label-MS Homo sapiens
182 RAB5A 5868
Proximity Label-MS Homo sapiens
183 SEC13 6396
Proximity Label-MS Homo sapiens
184 ADCY9 115
Proximity Label-MS Homo sapiens
185 SLC27A4 10999
Affinity Capture-MS Homo sapiens
186 TMEM41A  
Two-hybrid Homo sapiens
187 PRKAR2A 5576
Proximity Label-MS Homo sapiens
188 EGFR 1956
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
189 PEX5 5830
Proximity Label-MS Homo sapiens
190 TMEM194A  
Proximity Label-MS Homo sapiens
191 GHITM 27069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
192 TMEM169  
Affinity Capture-MS Homo sapiens
193 TOMM70A 9868
Affinity Capture-MS Homo sapiens
194 DYNC1LI1 51143
Co-fractionation Homo sapiens
195 ATP2A1 487
Proximity Label-MS Homo sapiens
196 FAM134B 54463
Proximity Label-MS Homo sapiens
197 MTFR1  
Proximity Label-MS Homo sapiens
198 VRK2 7444
Proximity Label-MS Homo sapiens
199 DDB1 1642
Co-fractionation Homo sapiens
200 DDRGK1 65992
Proximity Label-MS Homo sapiens
201 WDR44 54521
Proximity Label-MS Homo sapiens
202 TMEM209 84928
Proximity Label-MS Homo sapiens
203 LEMD3  
Proximity Label-MS Homo sapiens
204 LMNA 4000
Proximity Label-MS Homo sapiens
205 OSBPL8 114882
Proximity Label-MS Homo sapiens
206 LARP4 113251
Proximity Label-MS Homo sapiens
207 HUWE1 10075
Affinity Capture-MS Homo sapiens
208 SPCS3 60559
Proximity Label-MS Homo sapiens
209 PIGP  
Two-hybrid Homo sapiens
210 SUN1 23353
Proximity Label-MS Homo sapiens
211 TRIM13  
Proximity Label-MS Homo sapiens
212 TMEM9 252839
Proximity Label-MS Homo sapiens
213 ILF3 3609
Co-fractionation Homo sapiens
214 AMTN  
Affinity Capture-MS Homo sapiens
215 PGRMC1 10857
Affinity Capture-MS Homo sapiens
216 NUP85 79902
Proximity Label-MS Homo sapiens
217 C3AR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
218 GOSR1 9527
Affinity Capture-MS Homo sapiens
219 RFWD2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
220 PDCL 5082
Proximity Label-MS Homo sapiens
221 SEC23B 10483
Proximity Label-MS Homo sapiens
222 NSDHL 50814
Proximity Label-MS Homo sapiens
223 THEM6  
Proximity Label-MS Homo sapiens
224 PALD1 27143
Proximity Label-MS Homo sapiens
225 PRKAR2B 5577
Proximity Label-MS Homo sapiens
226 HNRNPK 3190
Co-fractionation Homo sapiens
227 RAD50 10111
Co-fractionation Homo sapiens
228 MMGT1 93380
Proximity Label-MS Homo sapiens
229 AUP1 550
Proximity Label-MS Homo sapiens
230 AHCYL2 23382
Proximity Label-MS Homo sapiens
231 ERGIC2 51290
Proximity Label-MS Homo sapiens
232 OSBPL3 26031
Proximity Label-MS Homo sapiens
233 ST7  
Proximity Label-MS Homo sapiens
234 TECTB  
Affinity Capture-MS Homo sapiens
235 ATP1A1 476
Proximity Label-MS Homo sapiens
236 YKT6 10652
Proximity Label-MS Homo sapiens
237 ARF1 375
Affinity Capture-MS Homo sapiens
238 C1QBP 708
Proximity Label-MS Homo sapiens
239 KRAS 3845
Proximity Label-MS Homo sapiens
240 CKAP4 10970
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
241 PTRF 284119
Affinity Capture-MS Homo sapiens
242 EIF2AK3  
Proximity Label-MS Homo sapiens
243 JAK2 3717
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
244 CALR3  
Affinity Capture-MS Homo sapiens
245 ZDBF2  
Proximity Label-MS Homo sapiens
246 STRA6 64220
Affinity Capture-MS Homo sapiens
247 MVP 9961
Affinity Capture-MS Homo sapiens
248 ATP6V1B2 526
Affinity Capture-MS Homo sapiens
249 SUCO  
Proximity Label-MS Homo sapiens
250 LYPD3 27076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
251 MTCH1 23787
Proximity Label-MS Homo sapiens
252 DHCR24 1718
Affinity Capture-MS Homo sapiens
253 MARCKS 4082
Proximity Label-MS Homo sapiens
254 STAT5A 6776
Protein-peptide Homo sapiens
255 UBE4A 9354
Proximity Label-MS Homo sapiens
256 NBAS 51594
Proximity Label-MS Homo sapiens
257 SSB 6741
Co-fractionation Homo sapiens
258 SYNE2 23224
Proximity Label-MS Homo sapiens
259 APBB1  
Proximity Label-MS Homo sapiens
260 DERL1 79139
Proximity Label-MS Homo sapiens
261 LTN1 26046
Affinity Capture-MS Homo sapiens
262 RTN4 57142
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
263 CAPZB 832
Co-fractionation Homo sapiens
264 TEX264 51368
Proximity Label-MS Homo sapiens
265 HEATR3 55027
Affinity Capture-MS Homo sapiens
266 TMEM183A  
Affinity Capture-MS Homo sapiens
267 SENP1  
Proximity Label-MS Homo sapiens
268 TIMMDC1  
Two-hybrid Homo sapiens
269 RAB3B 5865
Proximity Label-MS Homo sapiens
270 STAT3 6774
Biochemical Activity Homo sapiens
271 LSG1  
Proximity Label-MS Homo sapiens
272 SSR1 6745
Proximity Label-MS Homo sapiens
273 PIGH  
Affinity Capture-MS Homo sapiens
274 CCDC47 57003
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
275 MXRA7 439921
Proximity Label-MS Homo sapiens
276 MTDH 92140
Proximity Label-MS Homo sapiens
277 MAVS 57506
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
278 ESYT2 57488
Proximity Label-MS Homo sapiens
279 PABPC4 8761
Co-fractionation Homo sapiens
280 DHRS7 51635
Proximity Label-MS Homo sapiens
281 NUP155 9631
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
282 PXMP2  
Proximity Label-MS Homo sapiens
283 ENPP6 133121
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
284 CLK2 1196
Biochemical Activity Homo sapiens
285 BCAR1 9564
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
286 SCFD1 23256
Proximity Label-MS Homo sapiens
287 BNIP1 662
Proximity Label-MS Homo sapiens
288 ANTXR1 84168
Affinity Capture-MS Homo sapiens
289 PARK2  
Affinity Capture-MS Homo sapiens
290 IGF1R 3480
Affinity Capture-Western Homo sapiens
291 COPE 11316
Proximity Label-MS Homo sapiens
292 RAB4A 5867
Proximity Label-MS Homo sapiens
293 VANGL1 81839
Proximity Label-MS Homo sapiens
294 NTRK1 4914
Protein-peptide Homo sapiens
295 CARM1 10498
Co-fractionation Homo sapiens
296 TACC1 6867
Proximity Label-MS Homo sapiens
297 DHFRL1  
Proximity Label-MS Homo sapiens
298 SMS 6611
Co-fractionation Homo sapiens
299 TSPAN31 6302
Affinity Capture-MS Homo sapiens
300 MFF 56947
Proximity Label-MS Homo sapiens
301 DNM1L 10059
Proximity Label-MS Homo sapiens
302 RMDN3 55177
Co-localization Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
303 SLC4A7 9497
Proximity Label-MS Homo sapiens
304 NPPC  
Affinity Capture-MS Homo sapiens
305 DUSP1  
Affinity Capture-MS Homo sapiens
306 NUP37 79023
Proximity Label-MS Homo sapiens
307 SRPR 6734
Proximity Label-MS Homo sapiens
308 ITPR2 3709
Proximity Label-MS Homo sapiens
309 EMC3 55831
Proximity Label-MS Homo sapiens
310 TTYH1  
Affinity Capture-MS Homo sapiens
311 ECT2 1894
Affinity Capture-MS Homo sapiens
312 SMIM5  
Affinity Capture-MS Homo sapiens
313 TMPRSS3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
314 LMNB2 84823
Proximity Label-MS Homo sapiens
315 CASC4 113201
Affinity Capture-MS Homo sapiens
316 STIM1 6786
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
317 NIPAL1  
Affinity Capture-MS Homo sapiens
318 VAMP3 9341
Proximity Label-MS Homo sapiens
319 OCIAD1 54940
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
320 OSBPL11 114885
Proximity Label-MS Homo sapiens
321 MREG  
Affinity Capture-MS Homo sapiens
322 C3orf18  
Affinity Capture-MS Homo sapiens
323 MCMBP 79892
Co-fractionation Homo sapiens
324 EMC2 9694
Proximity Label-MS Homo sapiens
325 SEC16A 9919
Proximity Label-MS Homo sapiens
326 RAB9A 9367
Proximity Label-MS Homo sapiens
327 GPR21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
328 ACTB 60
Affinity Capture-MS Homo sapiens
329 RPN1 6184
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
330 KTN1 3895
Proximity Label-MS Homo sapiens
331 GALNT2 2590
Affinity Capture-MS Homo sapiens
332 MSN 4478
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
333 MAGT1 84061
Proximity Label-MS Homo sapiens
334 FLOT1 10211
Affinity Capture-MS Homo sapiens
335 SLC12A2 6558
Proximity Label-MS Homo sapiens
336 ACBD5 91452
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
337 UBE2J1 51465
Proximity Label-MS Homo sapiens
338 IMMT 10989
Proximity Label-MS Homo sapiens
339 HERC1 8925
Proximity Label-MS Homo sapiens
340 DDX50 79009
Proximity Label-MS Homo sapiens
341 PRMT3 10196
Co-fractionation Homo sapiens
342 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
343 PHB2 11331
Affinity Capture-MS Homo sapiens
344 ALDH3A2 224
Proximity Label-MS Homo sapiens
345 GPR89A  
Proximity Label-MS Homo sapiens
346 RAB3GAP2 25782
Proximity Label-MS Homo sapiens
347 TOR1AIP2 163590
Proximity Label-MS Homo sapiens
348 ASF1B  
Co-fractionation Homo sapiens
349 RTN3 10313
Proximity Label-MS Homo sapiens
350 TMCC3  
Proximity Label-MS Homo sapiens
351 ERLIN2 11160
Proximity Label-MS Homo sapiens
352 FLOT2 2319
Affinity Capture-MS Homo sapiens
353 ERGIC1 57222
Proximity Label-MS Homo sapiens
354 LTK 4058
Protein-peptide Homo sapiens
355 UFL1 23376
Proximity Label-MS Homo sapiens
356 SCN4A  
Affinity Capture-MS Homo sapiens
357 INF2 64423
Proximity Label-MS Homo sapiens
358 Clk1  
Biochemical Activity Mus musculus
359 RAB7A 7879
Proximity Label-MS Homo sapiens
360 TMEM38B  
Proximity Label-MS Homo sapiens
361 AGPAT6 137964
Proximity Label-MS Homo sapiens
362 SERBP1 26135
Affinity Capture-MS Homo sapiens
363 STT3B 201595
Proximity Label-MS Homo sapiens
364 GHR  
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
365 TMEM31  
Two-hybrid Homo sapiens
366 FLAD1 80308
Affinity Capture-MS Homo sapiens
367 WDR41  
Proximity Label-MS Homo sapiens
368 CAV1 857
Affinity Capture-Western Homo sapiens
369 HSD17B11 51170
Proximity Label-MS Homo sapiens
370 C5AR1  
Affinity Capture-MS Homo sapiens
371 POR 5447
Proximity Label-MS Homo sapiens
372 ANKLE2 23141
Proximity Label-MS Homo sapiens
373 DERL2 51009
Affinity Capture-MS Homo sapiens
374 PSMD6 9861
Co-fractionation Homo sapiens
375 VAPA 9218
Proximity Label-MS Homo sapiens
376 ELOVL2  
Proximity Label-MS Homo sapiens
377 CTDNEP1 23399
Proximity Label-MS Homo sapiens
378 ASGR2  
Affinity Capture-MS Homo sapiens
379 TMEM9B 56674
Affinity Capture-MS Homo sapiens
380 LAMP2 3920
Proximity Label-MS Homo sapiens
381 DNAJC25 548645
Proximity Label-MS Homo sapiens
382 GRAMD1A  
Proximity Label-MS Homo sapiens
383 PDE3B  
Proximity Label-MS Homo sapiens
384 TNFSF18 8995
Affinity Capture-MS Homo sapiens
385 SNRPD2 6633
Affinity Capture-MS Homo sapiens
386 PEX1 5189
Proximity Label-MS Homo sapiens
387 SRP54 6729
Proximity Label-MS Homo sapiens
388 RPS20 6224
Co-fractionation Homo sapiens
389 B3GAT1  
Proximity Label-MS Homo sapiens
390 COX11  
Affinity Capture-MS Homo sapiens
391 SMCR8 140775
Proximity Label-MS Homo sapiens
392 OTUB1 55611
Co-fractionation Homo sapiens
393 TSNAX 7257
Co-fractionation Homo sapiens
394 STIM2 57620
Proximity Label-MS Homo sapiens
395 KIF5B 3799
Co-fractionation Homo sapiens
396 IMPDH2 3615
Co-fractionation Homo sapiens
397 STX18 53407
Proximity Label-MS Homo sapiens
398 AHCY 191
Co-fractionation Homo sapiens
399 RTN1 6252
Proximity Label-MS Homo sapiens
400 NUP98 4928
Proximity Label-MS Homo sapiens
401 PGRMC2 10424
Proximity Label-MS Homo sapiens
402 EXD2  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
403 DNAJC16  
Proximity Label-MS Homo sapiens
404 BCOR  
Affinity Capture-MS Homo sapiens
405 CCDC115 84317
Proximity Label-MS Homo sapiens
406 ATP6V0D1 9114
Affinity Capture-MS Homo sapiens
407 SEC23A 10484
Proximity Label-MS Homo sapiens
408 RAB35 11021
Proximity Label-MS Homo sapiens
409 ARL1 400
Affinity Capture-MS Homo sapiens
410 FAF2 23197
Proximity Label-MS Homo sapiens
411 FAM20C 56975
Affinity Capture-MS Homo sapiens
412 SLCO6A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
413 LRRC59 55379
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
414 GEMIN5 25929
Co-fractionation Homo sapiens
415 ARHGAP12  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
416 EMD 2010
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
417 CEP295  
Co-fractionation Homo sapiens
418 CCT5 22948
Co-fractionation Homo sapiens
419 ATF2  
Affinity Capture-MS Homo sapiens
420 APLP2 334
Affinity Capture-MS Homo sapiens
421 DCUN1D5 84259
Affinity Capture-MS Homo sapiens
422 OPA1 4976
Proximity Label-MS Homo sapiens
423 MIA3 375056
Proximity Label-MS Homo sapiens
424 ZMPSTE24 10269
Co-fractionation Homo sapiens
425 DDX54 79039
Proximity Label-MS Homo sapiens
426 AIP 9049
Affinity Capture-MS Homo sapiens
427 VMA21  
Proximity Label-MS Homo sapiens
428 RHOT2 89941
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
429 ELOVL5 60481
Proximity Label-MS Homo sapiens
430 SLC33A1 9197
Proximity Label-MS Homo sapiens
431 DNAJB11 51726
Co-fractionation Homo sapiens
432 ZACN  
Affinity Capture-MS Homo sapiens
433 USP32 84669
Affinity Capture-MS Homo sapiens
434 SNAP29 9342
Proximity Label-MS Homo sapiens
435 TEX2 55852
Proximity Label-MS Homo sapiens
436 ASH2L 9070
Co-fractionation Homo sapiens
437 SEC63 11231
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
438 PKMYT1  
Proximity Label-MS Homo sapiens
439 TOR1AIP1 26092
Proximity Label-MS Homo sapiens
440 GOLGA3 2802
Proximity Label-MS Homo sapiens
441 IPO5 3843
Co-fractionation Homo sapiens
442 VAPB 9217
Proximity Label-MS Homo sapiens
443 ATP6AP2 10159
Proximity Label-MS Homo sapiens
444 PANX1 24145
Proximity Label-MS Homo sapiens
445 CCT6A 908
Co-fractionation Homo sapiens
446 HMOX2 3163
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
447 CTNNB1 1499
Reconstituted Complex Homo sapiens
448 ARF6 382
Proximity Label-MS Homo sapiens
449 EHBP1 23301
Proximity Label-MS Homo sapiens
450 PSMA4 5685
Co-fractionation Homo sapiens
451 ACSL3 2181
Proximity Label-MS Homo sapiens
452 C1orf210  
Affinity Capture-MS Homo sapiens
453 ACKR2  
Affinity Capture-MS Homo sapiens
454 FNDC3A 22862
Proximity Label-MS Homo sapiens
455 NDUFAF4 29078
Affinity Capture-MS Homo sapiens
456 STBD1 8987
Proximity Label-MS Homo sapiens
457 TRIM28 10155
Co-fractionation Homo sapiens
458 BRD3 8019
Affinity Capture-MS Homo sapiens
459 ATP6AP1 537
Proximity Label-MS Homo sapiens
460 SEC24B 10427
Proximity Label-MS Homo sapiens
461 LBR 3930
Proximity Label-MS Homo sapiens
462 DHX15 1665
Co-fractionation Homo sapiens
463 TTC17 55761
Proximity Label-MS Homo sapiens
464 RRBP1 6238
Proximity Label-MS Homo sapiens
465 SLMAP 7871
Proximity Label-MS Homo sapiens
466 NUP133 55746
Proximity Label-MS Homo sapiens
467 MCAT 27349
Co-fractionation Homo sapiens
468 SYAP1 94056
Proximity Label-MS Homo sapiens
469 SRP72 6731
Proximity Label-MS Homo sapiens
470 RAB3GAP1 22930
Proximity Label-MS Homo sapiens
471 VPS33B 26276
Proximity Label-MS Homo sapiens
472 TMCC1 23023
Proximity Label-MS Homo sapiens
473 TMX4 56255
Proximity Label-MS Homo sapiens
474 MIA2  
Proximity Label-MS Homo sapiens
475 ARF4 378
Affinity Capture-MS Homo sapiens
476 ATP6V1F 9296
Proximity Label-MS Homo sapiens
477 USP30  
Proximity Label-MS Homo sapiens
478 NUP107 57122
Proximity Label-MS Homo sapiens
479 CLMN  
Proximity Label-MS Homo sapiens
480 SEC62 7095
Proximity Label-MS Homo sapiens
481 LPAR2 9170
Affinity Capture-MS Homo sapiens
482 CDK5RAP3 80279
Proximity Label-MS Homo sapiens
483 MOSPD2 158747
Proximity Label-MS Homo sapiens
484 DNAJC1 64215
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
485 HNRNPU 3192
Co-fractionation Homo sapiens
486 C9orf72  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
487 IRS1 3667
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
488 ELOVL4  
Two-hybrid Homo sapiens
489 ESYT1 23344
Proximity Label-MS Homo sapiens
490 VEZT 55591
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PTPN1 is involved
PathwayEvidenceSource
Cellular responses to mechanical stimuli TAS Reactome
Cellular responses to stimuli TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
Cytokine Signaling in Immune system TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
Growth hormone receptor signaling IEA Reactome
Growth hormone receptor signaling TAS Reactome
Hemostasis TAS Reactome
Immune System IEA Reactome
Immune System TAS Reactome
Insulin receptor recycling TAS Reactome
Integrin signaling TAS Reactome
Interferon alpha/beta signaling TAS Reactome
Interferon gamma signaling IEA Reactome
Interferon Signaling IEA Reactome
Interferon Signaling TAS Reactome
MECP2 regulates neuronal receptors and channels TAS Reactome
Negative regulation of MET activity TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet Aggregation (Plug Formation) TAS Reactome
PTK6 Down-Regulation TAS Reactome
Regulation of IFNA/IFNB signaling TAS Reactome
Regulation of IFNG signaling IEA Reactome
Response of endothelial cells to shear stress TAS Reactome
RNA Polymerase II Transcription TAS Reactome
Signal Transduction TAS Reactome
Signaling by Insulin receptor TAS Reactome
Signaling by MET TAS Reactome
Signaling by Non-Receptor Tyrosine Kinases TAS Reactome
Signaling by PTK6 TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Transcriptional Regulation by MECP2 TAS Reactome
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells TAS Reactome





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