Gene description for IGF1R
Gene name	insulin-like growth factor 1 receptor
Gene symbol	IGF1R
Other names/aliases	CD221 IGFIR IGFR JTK13
Species	Homo sapiens
Database cross references - IGF1R
ExoCarta	ExoCarta_3480
Entrez Gene	3480
HGNC	5465
MIM	147370
UniProt	P08069
IGF1R identified in exosomes derived from the following tissue/cell type
Melanoma cells	25950383
Neuroblastoma cells	25944692
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for IGF1R

Molecular Function     insulin-like growth factor binding GO:0005520 IDA     protein tyrosine kinase activity GO:0004713 TAS     protein binding GO:0005515 IPI     insulin receptor binding GO:0005158 IDA     G-protein alpha-subunit binding GO:0001965 IEA     ATP binding GO:0005524 IEA     identical protein binding GO:0042802 IPI     insulin receptor substrate binding GO:0043560 IPI     insulin-like growth factor-activated receptor activity GO:0005010 IDA     insulin-like growth factor I binding GO:0031994 IPI     phosphatidylinositol 3-kinase binding GO:0043548 IPI     insulin binding GO:0043559 IPI Biological Process     positive regulation of cytokinesis GO:0032467 IEA     insulin-like growth factor receptor signaling pathway GO:0048009 IDA     negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 IEA     phosphatidylinositol-mediated signaling GO:0048015 IDA     protein autophosphorylation GO:0046777 IDA     axonogenesis GO:0007409 IEA     positive regulation of mitotic nuclear division GO:0045840 IEA     brain development GO:0007420 IEA     response to vitamin E GO:0033197 IEA     positive regulation of cell proliferation GO:0008284 TAS     immune response GO:0006955 IMP     prostate gland epithelium morphogenesis GO:0060740 IEA     negative regulation of protein kinase B signaling GO:0051898 IEA     positive regulation of MAPK cascade GO:0043410 IEA     positive regulation of cell migration GO:0030335 IMP     positive regulation of protein kinase B signaling GO:0051897 IEA     insulin receptor signaling pathway GO:0008286 TAS     signal transduction GO:0007165 TAS     positive regulation of steroid hormone biosynthetic process GO:0090031 IEA     protein tetramerization GO:0051262 IDA     negative regulation of muscle cell apoptotic process GO:0010656 IEA     phosphatidylinositol 3-kinase signaling GO:0014065 IC     positive regulation of DNA replication GO:0045740 IMP     male sex determination GO:0030238 IEA     mammary gland development GO:0030879 IEA     negative regulation of apoptotic process GO:0043066 IDA     regulation of JNK cascade GO:0046328 IDA     peptidyl-tyrosine autophosphorylation GO:0038083 IMP     epidermis development GO:0008544 IEA     exocrine pancreas development GO:0031017 IEA     inactivation of MAPKK activity GO:0051389 IDA     establishment of cell polarity GO:0030010 IEA     protein heterooligomerization GO:0051291 IEA Subcellular Localization     neuron projection GO:0043005 IEA     integral component of plasma membrane GO:0005887 IC     receptor complex GO:0043235 IDA     membrane GO:0016020 IDA     intracellular membrane-bounded organelle GO:0043231 IDA     plasma membrane GO:0005886 TAS     caveola GO:0005901 IEA