Gene description for ARPP19
Gene name cAMP-regulated phosphoprotein, 19kDa
Gene symbol ARPP19
Other names/aliases ARPP-16
ARPP-19
ARPP16
ENSAL
Species Homo sapiens
 Database cross references - ARPP19
ExoCarta ExoCarta_10776
Entrez Gene 10776
HGNC 16967
MIM 605487
UniProt P56211  
 ARPP19 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ARPP19
Molecular Function
    protein phosphatase inhibitor activity GO:0004864 IEA
    protein phosphatase type 2A regulator activity GO:0008601 ISS
    phosphatase inhibitor activity GO:0019212 ISS
    protein phosphatase 2A binding GO:0051721 ISS
    potassium channel regulator activity GO:0015459 IDA
    receptor binding GO:0005102 IDA
Biological Process
    dopamine receptor signaling pathway GO:0007212 IEA
    cell division GO:0051301 IEA
    regulation of protein phosphatase type 2A activity GO:0034047 ISS
    G2/M transition of mitotic cell cycle GO:0000086 IMP
    positive regulation of Ras protein signal transduction GO:0046579 IEA
    mitotic cell cycle GO:0000278 TAS
    mitotic nuclear division GO:0007067 IMP
    positive regulation of gluconeogenesis GO:0045722 IDA
    positive regulation of glucose import GO:0046326 NAS
    negative regulation of catalytic activity GO:0043086 ISS
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified ARPP19 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ARPP19
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ARPP19 is involved
PathwayEvidenceSource
MASTL Facilitates Mitotic Progression TAS Reactome





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