Gene description for INSRR
Gene name insulin receptor-related receptor
Gene symbol INSRR
Other names/aliases IRR
Species Homo sapiens
 Database cross references - INSRR
ExoCarta ExoCarta_3645
Entrez Gene 3645
HGNC 6093
MIM 147671
UniProt P14616  
 INSRR identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for INSRR
Molecular Function
    phosphatidylinositol 3-kinase binding GO:0043548 IEA
    insulin receptor substrate binding GO:0043560 IEA
    ATP binding GO:0005524 IEA
    transmembrane receptor protein tyrosine kinase activity GO:0004714 NAS
Biological Process
    protein autophosphorylation GO:0046777 IMP
    peptidyl-tyrosine phosphorylation GO:0018108 NAS
    cellular response to alkaline pH GO:0071469 IDA
    actin cytoskeleton reorganization GO:0031532 IDA
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 NAS
    male sex determination GO:0030238 IEA
Subcellular Localization
    integral component of plasma membrane GO:0005887 NAS
    receptor complex GO:0043235 IDA
 Experiment description of studies that identified INSRR in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for INSRR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 INSR 3643
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which INSRR is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here