Gene description for CTDSP2
Gene name CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
Gene symbol CTDSP2
Other names/aliases OS4
PSR2
SCP2
Species Homo sapiens
 Database cross references - CTDSP2
ExoCarta ExoCarta_10106
Vesiclepedia VP_10106
Entrez Gene 10106
HGNC 17077
MIM 608711
UniProt O14595  
 CTDSP2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CTDSP2
Molecular Function
    protein binding GO:0005515 IPI
    RNA polymerase II CTD heptapeptide repeat phosphatase activity GO:0008420 IBA
    RNA polymerase II CTD heptapeptide repeat phosphatase activity GO:0008420 IDA
    myosin phosphatase activity GO:0017018 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    metal ion binding GO:0046872 IEA
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    protein dephosphorylation GO:0006470 IDA
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 IEA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified CTDSP2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CTDSP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP2B3 492
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 TUBA1A 7846
Affinity Capture-MS Homo sapiens
3 P4HA1 5033
Affinity Capture-MS Homo sapiens
4 VPS41 27072
Affinity Capture-MS Homo sapiens
5 TIMM50 92609
Affinity Capture-MS Homo sapiens
6 SETD1A 9739
Affinity Capture-MS Homo sapiens
7 MAP7 9053
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CTDSP1 58190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SNAI1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
10 ENDOD1 23052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 PLEKHH3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TBC1D4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CDCA3 83461
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 BSG 682
Affinity Capture-MS Homo sapiens
15 TUBB8 347688
Affinity Capture-MS Homo sapiens
16 ATP12A 479
Affinity Capture-MS Homo sapiens
17 ARF3 377
Proximity Label-MS Homo sapiens
18 ANKRD13D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 POM121  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 GPA33 10223
Affinity Capture-MS Homo sapiens
21 DDX58 23586
Affinity Capture-RNA Homo sapiens
22 POLR2A 5430
Biochemical Activity Homo sapiens
23 NEK1  
Affinity Capture-MS Homo sapiens
24 TUBB6 84617
Affinity Capture-MS Homo sapiens
25 APEX1 328
Affinity Capture-RNA Homo sapiens
26 TYRO3 7301
Two-hybrid Homo sapiens
27 EPHA3 2042
Two-hybrid Homo sapiens
28 MAP7D1 55700
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 ZMYM6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SLC25A4 291
Affinity Capture-MS Homo sapiens
31 INSRR 3645
Two-hybrid Homo sapiens
32 SLC25A20 788
Affinity Capture-MS Homo sapiens
33 PRR14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 RAB7A 7879
Proximity Label-MS Homo sapiens
35 NEK4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 N4BP3  
Two-hybrid Homo sapiens
37 RPS27L 51065
Affinity Capture-MS Homo sapiens
38 UBTF 7343
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 DNAJA3 9093
Affinity Capture-MS Homo sapiens
40 LCN2 3934
Two-hybrid Homo sapiens
41 CWC22 57703
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 HAX1  
Affinity Capture-MS Homo sapiens
43 ZC3H3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 CSF1R  
Two-hybrid Homo sapiens
45 CTDSPL 10217
Affinity Capture-MS Homo sapiens
46 EPHA1 2041
Two-hybrid Homo sapiens
47 ANKRD13A 88455
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 MBP 4155
Affinity Capture-MS Homo sapiens
49 PTK7 5754
Two-hybrid Homo sapiens
50 INTS6 26512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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