Gene description for UBTF
Gene name upstream binding transcription factor, RNA polymerase I
Gene symbol UBTF
Other names/aliases NOR-90
UBF
UBF-1
UBF1
UBF2
Species Homo sapiens
 Database cross references - UBTF
ExoCarta ExoCarta_7343
Entrez Gene 7343
HGNC 12511
MIM 600673
UniProt P17480  
 UBTF identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for UBTF
Molecular Function
    protein binding GO:0005515 IPI
    chromatin binding GO:0003682 IBA
    poly(A) RNA binding GO:0044822 IDA
    DNA binding GO:0003677 IEA
Biological Process
    positive regulation of transcription from RNA polymerase I promoter GO:0045943 ISS
    regulation of transcription from RNA polymerase I promoter GO:0006356 TAS
    chromatin remodeling GO:0006338 IBA
    transcription from RNA polymerase I promoter GO:0006360 TAS
    termination of RNA polymerase I transcription GO:0006363 TAS
    transcription elongation from RNA polymerase I promoter GO:0006362 TAS
    negative regulation of gene expression, epigenetic GO:0045814 TAS
    transcription initiation from RNA polymerase I promoter GO:0006361 TAS
    gene expression GO:0010467 TAS
    regulation of gene expression, epigenetic GO:0040029 TAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 ISS
 Experiment description of studies that identified UBTF in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for UBTF
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TAF1C  
Reconstituted Complex Homo sapiens
2 CSNK2A1 1457
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
3 TBP  
Affinity Capture-Western Homo sapiens
4 CENPC1  
Invivo Homo sapiens
Invitro Homo sapiens
5 RB1 5925
Invivo Homo sapiens
Invitro Homo sapiens
6 IRS2 8660
Invivo Homo sapiens
7 LEF1  
Affinity Capture-Western Homo sapiens
8 RRN3  
Affinity Capture-Western Homo sapiens
9 CD3EAP  
Reconstituted Complex Homo sapiens
10 RBL2 5934
Invivo Homo sapiens
11 SERPINH1 871
Invivo Homo sapiens
Invitro Homo sapiens
12 PAF53  
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
13 TAF1  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
14 IRS1 3667
Invivo Homo sapiens
View the network image/svg+xml



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