Gene description for CPNE7
Gene name copine VII
Gene symbol CPNE7
Other names/aliases -
Species Homo sapiens
 Database cross references - CPNE7
ExoCarta ExoCarta_27132
Vesiclepedia VP_27132
Entrez Gene 27132
HGNC 2320
MIM 605689
UniProt Q9UBL6  
 CPNE7 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CPNE7
Molecular Function
    protein binding GO:0005515 IPI
    calcium-dependent phospholipid binding GO:0005544 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    lipid metabolic process GO:0006629 TAS
    cellular response to calcium ion GO:0071277 IBA
    cellular response to calcium ion GO:0071277 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    synapse GO:0045202 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CPNE7 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CPNE7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF774  
Two-hybrid Homo sapiens
2 CEP57  
Affinity Capture-MS Homo sapiens
3 KIF16B 55614
Affinity Capture-MS Homo sapiens
4 FOXF2  
Affinity Capture-MS Homo sapiens
5 SURF6  
Affinity Capture-MS Homo sapiens
6 C12orf74  
Affinity Capture-MS Homo sapiens
7 GSTO1 9446
Affinity Capture-MS Homo sapiens
8 PKLR 5313
Two-hybrid Homo sapiens
9 MS4A7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CSNK2B 1460
Two-hybrid Homo sapiens
11 METTL2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 WASF3 10810
Affinity Capture-MS Homo sapiens
13 USP53 54532
Affinity Capture-MS Homo sapiens
14 NECAB1  
Two-hybrid Homo sapiens
15 TP53 7157
Affinity Capture-MS Homo sapiens
16 DOCK8 81704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 FAM154A  
Two-hybrid Homo sapiens
18 RNF19B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 ADAMTSL4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
20 REL 5966
Two-hybrid Homo sapiens
21 OTP  
Two-hybrid Homo sapiens
22 SREBF1 6720
Negative Genetic Homo sapiens
23 KRT75 9119
Two-hybrid Homo sapiens
24 TUBGCP3 10426
Affinity Capture-MS Homo sapiens
25 C6orf203  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SETD2  
Affinity Capture-MS Homo sapiens
27 CUL3 8452
Affinity Capture-MS Homo sapiens
28 TRIM27  
Two-hybrid Homo sapiens
29 GEMIN8 54960
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CAND1 55832
Affinity Capture-MS Homo sapiens
31 RPS27A 6233
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 ZDHHC19  
Affinity Capture-MS Homo sapiens
33 ASPDH  
Affinity Capture-MS Homo sapiens
34 DDIT4L  
Two-hybrid Homo sapiens
35 PBX4  
Two-hybrid Homo sapiens
36 CDCA4 55038
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 MAGIX 79917
Affinity Capture-MS Homo sapiens
38 BRD1 23774
Affinity Capture-MS Homo sapiens
39 ZFP90  
Two-hybrid Homo sapiens
40 ZNF18  
Two-hybrid Homo sapiens
41 CEP250 11190
Affinity Capture-MS Homo sapiens
42 ZNF655  
Two-hybrid Homo sapiens
43 CDK20  
Affinity Capture-MS Homo sapiens
44 ZMIZ2  
Two-hybrid Homo sapiens
45 THAP4 51078
Affinity Capture-MS Homo sapiens
46 TRIM23 373
Two-hybrid Homo sapiens
47 VWA2 340706
Affinity Capture-MS Homo sapiens
48 OTUB1 55611
Affinity Capture-MS Homo sapiens
49 MCM2 4171
Affinity Capture-MS Homo sapiens
50 LHX3  
Two-hybrid Homo sapiens
51 ZNF572  
Two-hybrid Homo sapiens
52 CRAMP1L 57585
Affinity Capture-MS Homo sapiens
53 COPS5 10987
Affinity Capture-MS Homo sapiens
54 MEOX2  
Two-hybrid Homo sapiens
55 BAHCC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 UBTF 7343
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 DUSP21  
Two-hybrid Homo sapiens
58 EBF3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 CALCOCO2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
60 EFHC2  
Two-hybrid Homo sapiens
61 GPX7 2882
Two-hybrid Homo sapiens
62 KLHL14 57565
Affinity Capture-MS Homo sapiens
63 SUPT5H 6829
Affinity Capture-MS Homo sapiens
64 ENTHD2  
Two-hybrid Homo sapiens
65 ZNF474  
Two-hybrid Homo sapiens
66 OPALIN  
Affinity Capture-MS Homo sapiens
67 CHMP4A 29082
Affinity Capture-MS Homo sapiens
68 CPNE4 131034
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CPNE7 is involved
PathwayEvidenceSource
Glycerophospholipid biosynthesis TAS Reactome
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Phospholipid metabolism TAS Reactome





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