Gene description for CPNE4
Gene name copine IV
Gene symbol CPNE4
Other names/aliases COPN4
CPN4
Species Homo sapiens
 Database cross references - CPNE4
ExoCarta ExoCarta_131034
Vesiclepedia VP_131034
Entrez Gene 131034
HGNC 2317
MIM 604208
UniProt Q96A23  
 CPNE4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CPNE4
Subcellular Localization
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified CPNE4 in exosomes
1
Experiment ID 237
MISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CPNE4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cdc42bpb 217866
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
2 Skil  
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
3 B230113M03Rik  
Two-hybrid Mus musculus
4 MYCBP 26292
Affinity Capture-MS Homo sapiens
5 Mycbp2 105689
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
6 Bicd2  
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
7 Ccdc22  
Reconstituted Complex Mus musculus
8 Ube2m 22192
Reconstituted Complex Mus musculus
9 4922501C03Rik  
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
10 PDCD6 10016
Affinity Capture-MS Homo sapiens
11 DXImx40e  
Two-hybrid Mus musculus
12 Ube2o 217342
Reconstituted Complex Mus musculus
13 Actb 11461
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
14 CPNE1 8904
Affinity Capture-MS Homo sapiens
15 Sptbn1 20742
Reconstituted Complex Mus musculus
16 Alg2 56737
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
17 Map2k1 26395
Reconstituted Complex Mus musculus
18 BC026657  
Reconstituted Complex Mus musculus
19 Cenpf  
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
20 Pitpnm2  
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
21 Spnb2  
Two-hybrid Mus musculus
22 Rdx 19684
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
23 Ppp5c  
Reconstituted Complex Mus musculus
24 Cpne1 266692
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
25 ACTB 60
Affinity Capture-MS Homo sapiens
26 CCDC22 28952
Affinity Capture-MS Homo sapiens
27 Bcor  
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
28 Nono 53610
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which CPNE4 is involved
No pathways found





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