Gene description for Cdc42bpb
Gene name CDC42 binding protein kinase beta
Gene symbol Cdc42bpb
Other names/aliases MRCKb
Species Mus musculus
 Database cross references - Cdc42bpb
ExoCarta ExoCarta_217866
Vesiclepedia VP_217866
Entrez Gene 217866
UniProt Q7TT50  
 Cdc42bpb identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cdc42bpb
Molecular Function
    metal ion binding GO:0046872 IEA
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    protein kinase activity GO:0004672 ISO
    protein serine/threonine kinase activity GO:0004674 ISO
    nucleotide binding GO:0000166 IEA
    transferase activity GO:0016740 IEA
    ATP binding GO:0005524 IEA
    kinase activity GO:0016301 IEA
    Rho GTPase binding GO:0017048 ISO
Biological Process
    phosphorylation GO:0016310 IEA
    actomyosin structure organization GO:0031032 ISO
    intracellular signal transduction GO:0035556 IEA
    cell migration GO:0016477 ISO
    actin cytoskeleton organization GO:0030036 ISO
    protein phosphorylation GO:0006468 ISO
Subcellular Localization
    cell junction GO:0030054 IEA
    membrane GO:0016020 IEA
    extracellular exosome GO:0070062 ISO
    actomyosin GO:0042641 ISO
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified Cdc42bpb in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cdc42bpb
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CPNE1 8904
Reconstituted Complex Homo sapiens
2 CPNE4 131034
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which Cdc42bpb is involved
No pathways found





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