Gene description for CPNE6
Gene name copine VI (neuronal)
Gene symbol CPNE6
Other names/aliases -
Species Homo sapiens
 Database cross references - CPNE6
ExoCarta ExoCarta_9362
Entrez Gene 9362
HGNC 2319
MIM 605688
UniProt O95741  
 CPNE6 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for CPNE6
Molecular Function
    calcium ion binding GO:0005509 TAS
    protein binding GO:0005515 IPI
    phosphatidylserine binding GO:0001786 IEA
    transporter activity GO:0005215 TAS
Biological Process
    phospholipid metabolic process GO:0006644 TAS
    positive regulation of dendrite extension GO:1903861 IDA
    synaptic transmission GO:0007268 TAS
    nervous system development GO:0007399 TAS
    small molecule metabolic process GO:0044281 TAS
    vesicle-mediated transport GO:0016192 TAS
    lipid metabolic process GO:0006629 TAS
    glycerophospholipid biosynthetic process GO:0046474 TAS
Subcellular Localization
    dendrite GO:0030425 IEA
    axon GO:0030424 IEA
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified CPNE6 in exosomes
1
Experiment ID 274
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for CPNE6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AK5  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CPNE6 is involved
PathwayEvidenceSource
Glycerophospholipid biosynthesis TAS Reactome





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