Gene description for AK5
Gene name adenylate kinase 5
Gene symbol AK5
Other names/aliases AK6
Species Homo sapiens
 Database cross references - AK5
ExoCarta ExoCarta_26289
Vesiclepedia VP_26289
Entrez Gene 26289
HGNC 365
MIM 608009
UniProt Q9Y6K8  
 AK5 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for AK5
Molecular Function
    nucleoside diphosphate kinase activity GO:0004550 IDA
    adenylate kinase activity GO:0004017 IEA
    ATP binding GO:0005524 IEA
    nucleoside kinase activity GO:0019206 EXP
Biological Process
    nucleobase-containing small molecule metabolic process GO:0055086 TAS
    pyrimidine ribonucleotide biosynthetic process GO:0009220 TAS
    nucleobase-containing small molecule interconversion GO:0015949 TAS
    ATP metabolic process GO:0046034 IEA
    dADP biosynthetic process GO:0006173 TAS
    nucleoside diphosphate phosphorylation GO:0006165 IDA
    nucleoside triphosphate biosynthetic process GO:0009142 IDA
    ADP biosynthetic process GO:0006172 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IDA
    microtubule organizing center GO:0005815 IDA
 Experiment description of studies that identified AK5 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for AK5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STRN4 29888
Two-hybrid Homo sapiens
2 UGDH 7358
Two-hybrid Homo sapiens
3 TRIM46 80128
Two-hybrid Homo sapiens
4 RNF114 55905
Two-hybrid Homo sapiens
5 NUCKS1 64710
Two-hybrid Homo sapiens
6 C7orf26  
Two-hybrid Homo sapiens
7 CPNE6 9362
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which AK5 is involved
PathwayEvidenceSource
Synthesis and interconversion of nucleotide di- and triphosphates TAS Reactome





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