Gene description for AK5
Gene name adenylate kinase 5
Gene symbol AK5
Other names/aliases AK6
Species Homo sapiens
 Database cross references - AK5
ExoCarta ExoCarta_26289
Vesiclepedia VP_26289
Entrez Gene 26289
HGNC 365
MIM 608009
UniProt Q9Y6K8  
 AK5 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for AK5
Molecular Function
    adenylate kinase activity GO:0004017 IEA
    nucleoside diphosphate kinase activity GO:0004550 IBA
    nucleoside diphosphate kinase activity GO:0004550 IDA
    ATP binding GO:0005524 IEA
Biological Process
    ADP biosynthetic process GO:0006172 TAS
    dADP biosynthetic process GO:0006173 TAS
    pyrimidine ribonucleotide biosynthetic process GO:0009220 TAS
    ATP metabolic process GO:0046034 IEA
    nucleoside monophosphate phosphorylation GO:0046940 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    centriolar satellite GO:0034451 IDA
 Experiment description of studies that identified AK5 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for AK5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STRN4 29888
Two-hybrid Homo sapiens
2 UGDH 7358
Two-hybrid Homo sapiens
3 CEBPA  
Affinity Capture-MS Homo sapiens
4 TRIM46 80128
Two-hybrid Homo sapiens
5 RNF114 55905
Two-hybrid Homo sapiens
6 NUCKS1 64710
Two-hybrid Homo sapiens
7 C7orf26  
Two-hybrid Homo sapiens
8 CPNE6 9362
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which AK5 is involved
PathwayEvidenceSource
Interconversion of nucleotide di- and triphosphates TAS Reactome
Metabolism TAS Reactome
Metabolism of nucleotides TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here