Gene description for Sptbn1
Gene name spectrin beta, non-erythrocytic 1
Gene symbol Sptbn1
Other names/aliases 9930031C03Rik
Species Mus musculus
 Database cross references - Sptbn1
ExoCarta ExoCarta_20742
Entrez Gene 20742
UniProt Q62261  
 Sptbn1 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Sptbn1
Molecular Function
    ankyrin binding GO:0030506 ISO
    actin binding GO:0003779 IEA
    phospholipid binding GO:0005543 IEA
    calmodulin binding GO:0005516 IEA
    poly(A) RNA binding GO:0044822 ISO
    GTPase binding GO:0051020 ISO
    protein complex binding GO:0032403 ISO
    structural constituent of cytoskeleton GO:0005200 ISO
    protein binding GO:0005515 IPI
Biological Process
    common-partner SMAD protein phosphorylation GO:0007182 IDA
    SMAD protein import into nucleus GO:0007184 IDA
    regulation of protein localization to plasma membrane GO:1903076 ISO
    positive regulation of interleukin-2 secretion GO:1900042 ISO
    Golgi to plasma membrane protein transport GO:0043001 ISO
    membrane assembly GO:0071709 ISO
    actin filament capping GO:0051693 IEA
    protein targeting to plasma membrane GO:0072661 ISO
    plasma membrane organization GO:0007009 ISO
    positive regulation of protein localization to plasma membrane GO:1903078 ISO
    mitotic cytokinesis GO:0000281 ISO
Subcellular Localization
    membrane GO:0016020 IDA
    nucleus GO:0005634 IDA
    cytoskeleton GO:0005856 IEA
    nucleolus GO:0005730 ISO
    plasma membrane GO:0005886 IDA
    axolemma GO:0030673 IDA
    cuticular plate GO:0032437 IDA
    cell GO:0005623 IMP
    cytoplasm GO:0005737 ISO
    M band GO:0031430 IDA
    cortical cytoskeleton GO:0030863 IDA
    neuronal postsynaptic density GO:0097481 IDA
    spectrin GO:0008091 IEA
    extracellular exosome GO:0070062 ISO
    intracellular GO:0005622 IMP
    protein complex GO:0043234 ISO
 Experiment description of studies that identified Sptbn1 in exosomes
Experiment ID 188
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Sptbn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CPNE1 8904
Reconstituted Complex Homo sapiens
2 CPNE4 131034
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which Sptbn1 is involved
Interaction between L1 and Ankyrins IEA Reactome
NCAM signaling for neurite out-growth IEA Reactome
Nephrin interactions IEA Reactome

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