Gene description for Hspb2
Gene name heat shock protein 2
Gene symbol Hspb2
Other names/aliases 27kDa
2810021G24Rik
HSP27
MKBP
Species Mus musculus
 Database cross references - Hspb2
ExoCarta ExoCarta_69253
Vesiclepedia VP_69253
Entrez Gene 69253
UniProt Q99PR8  
 Hspb2 identified in exosomes derived from the following tissue/cell type
Brain cancer cells 19109410    
 Gene ontology annotations for Hspb2
Molecular Function
    structural constituent of eye lens GO:0005212 IEA
    unfolded protein binding GO:0051082 IBA
Biological Process
    somatic muscle development GO:0007525 IGI
    response to heat GO:0009408 IBA
    protein refolding GO:0042026 IBA
    negative regulation of apoptotic process GO:0043066 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified Hspb2 in exosomes
1
Experiment ID 26
MISEV standards
EM
Biophysical techniques
Alix|GAPDH|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method FACS
PubMed ID 19109410    
Organism Mus musculus
Experiment description Proteomic and immunologic analyses of brain tumor exosomes.
Authors Graner MW, Alzate O, Dechkovskaia AM, Keene JD, Sampson JH, Mitchell DA, Bigner DD
Journal name FASEB
Publication year 2008
Sample Brain cancer cells
Sample name SMA560vIII
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
 Protein-protein interactions for Hspb2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Lama2  
Affinity Capture-MS Mus musculus
2 Sptbn1 20742
Affinity Capture-MS Mus musculus
3 Actn1 109711
Affinity Capture-MS Mus musculus
4 Lamc1 226519
Affinity Capture-MS Mus musculus
5 Apoo  
Affinity Capture-MS Mus musculus
6 ND1  
Affinity Capture-MS Mus musculus
7 Akt1  
Affinity Capture-Western Mus musculus
8 Ndufb5  
Affinity Capture-MS Mus musculus
9 Naca 17938
Affinity Capture-MS Mus musculus
10 Crat  
Affinity Capture-MS Mus musculus
11 Ndufc2  
Affinity Capture-MS Mus musculus
12 Ap3d1  
Affinity Capture-MS Mus musculus
13 Opa1  
Affinity Capture-MS Mus musculus
14 Crip2  
Affinity Capture-MS Mus musculus
15 Mtx2  
Affinity Capture-MS Mus musculus
16 Sptan1 20740
Affinity Capture-MS Mus musculus
17 Vcl 22330
Affinity Capture-MS Mus musculus
18 Hspb2 69253
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
19 Cisd1  
Affinity Capture-MS Mus musculus
20 Uqcrh  
Affinity Capture-MS Mus musculus
21 Aifm1  
Affinity Capture-MS Mus musculus
22 Hspg2 15530
Affinity Capture-MS Mus musculus
23 D10Jhu81e  
Affinity Capture-MS Mus musculus
24 ND5  
Affinity Capture-MS Mus musculus
25 Slc25a12  
Affinity Capture-MS Mus musculus
26 Mapk14  
FRET Mus musculus
Affinity Capture-Western Mus musculus
27 Rab7 19349
Affinity Capture-MS Mus musculus
28 HSD17B10 3028
Affinity Capture-MS Homo sapiens
29 Atp5l  
Affinity Capture-MS Mus musculus
30 Ndufb8  
Affinity Capture-MS Mus musculus
31 Mccc1  
Affinity Capture-MS Mus musculus
32 Nnt 18115
Affinity Capture-MS Mus musculus
33 Cox7a2l  
Affinity Capture-MS Mus musculus
34 Ndufb6  
Affinity Capture-MS Mus musculus
35 Atp5k  
Affinity Capture-MS Mus musculus
36 Mrpl12  
Affinity Capture-MS Mus musculus
37 Slc25a42  
Affinity Capture-MS Mus musculus
38 Samm50  
Affinity Capture-MS Mus musculus
39 Ogdh 18293
Affinity Capture-MS Mus musculus
40 Ndufa11  
Affinity Capture-MS Mus musculus
41 Acad12  
Affinity Capture-MS Mus musculus
42 Maob 109731
Affinity Capture-MS Mus musculus
43 Mtch2  
Affinity Capture-MS Mus musculus
44 Auh  
Affinity Capture-MS Mus musculus
45 Ogdhl  
Affinity Capture-MS Mus musculus
46 Mtfp1  
Affinity Capture-MS Mus musculus
47 Slc25a5 11740
Affinity Capture-MS Mus musculus
48 Slc25a20  
Affinity Capture-MS Mus musculus
49 Phb 18673
Affinity Capture-MS Mus musculus
50 Ehd4 98878
Affinity Capture-MS Mus musculus
51 ND4  
Affinity Capture-MS Mus musculus
52 Tnnc1  
Affinity Capture-MS Mus musculus
53 Cpt2  
Affinity Capture-MS Mus musculus
54 Ndufb3  
Affinity Capture-MS Mus musculus
55 Ndufb9  
Affinity Capture-MS Mus musculus
56 Ndufb11  
Affinity Capture-MS Mus musculus
57 Fech  
Affinity Capture-MS Mus musculus
58 Plin4  
Affinity Capture-MS Mus musculus
59 Hspa8 15481
Affinity Capture-MS Mus musculus
60 Uqcrq  
Affinity Capture-MS Mus musculus
61 Nid1 18073
Affinity Capture-MS Mus musculus
62 Timmdc1  
Affinity Capture-MS Mus musculus
63 C1qbp 12261
Affinity Capture-MS Mus musculus
64 Cpt1b  
Affinity Capture-MS Mus musculus
65 Mpc2  
Affinity Capture-MS Mus musculus
66 Dld 13382
Affinity Capture-MS Mus musculus
67 Dlst  
Affinity Capture-MS Mus musculus
68 Cd36 12491
Affinity Capture-MS Mus musculus
69 Vim 22352
Affinity Capture-MS Mus musculus
70 Mccc2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Hspb2 is involved
No pathways found





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