Gene description for Dld
Gene name dihydrolipoamide dehydrogenase
Gene symbol Dld
Other names/aliases -
Species Mus musculus
 Database cross references - Dld
ExoCarta ExoCarta_13382
Entrez Gene 13382
UniProt O08749  
 Dld identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Dld
Molecular Function
    NAD binding GO:0051287 ISO
    dihydrolipoyl dehydrogenase activity GO:0004148 ISO
    oxidoreductase activity GO:0016491 IEA
    lipoamide binding GO:0043544 ISO
    oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor GO:0016668 IEA
    flavin adenine dinucleotide binding GO:0050660 ISO
Biological Process
    proteolysis GO:0006508 IDA
    sperm capacitation GO:0048240 IDA
    dihydrolipoamide metabolic process GO:0051068 ISO
    lipoate metabolic process GO:0009106 ISO
    gastrulation GO:0007369 IMP
    acetyl-CoA biosynthetic process from pyruvate GO:0006086 ISO
    regulation of membrane potential GO:0042391 IMP
    mitochondrial electron transport, NADH to ubiquinone GO:0006120 IMP
    2-oxoglutarate metabolic process GO:0006103 ISO
    cell redox homeostasis GO:0045454 IEA
    oxidation-reduction process GO:0055114 ISO
Subcellular Localization
    mitochondrion GO:0005739 ISO
    cilium GO:0005929 IDA
    oxoglutarate dehydrogenase complex GO:0045252 ISO
    myelin sheath GO:0043209 IDA
    acrosomal matrix GO:0043159 IDA
    nucleoplasm GO:0005654 ISO
    pyruvate dehydrogenase complex GO:0045254 ISO
 Experiment description of studies that identified Dld in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Dld
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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