Gene description for Pdhx
Gene name pyruvate dehydrogenase complex, component X
Gene symbol Pdhx
Other names/aliases AI481367
E3bp
Pdx1
Species Mus musculus
 Database cross references - Pdhx
ExoCarta ExoCarta_27402
Vesiclepedia VP_27402
Entrez Gene 27402
UniProt Q8BKZ9  
 Pdhx identified in sEVs derived from the following tissue/cell type
Osteosarcoma cells 33785738    
 Gene ontology annotations for Pdhx
Molecular Function
    acyltransferase activity GO:0016746 IEA
    pyruvate dehydrogenase (NAD+) activity GO:0034604 ISO
    molecular adaptor activity GO:0060090 ISO
Biological Process
    acetyl-CoA biosynthetic process from pyruvate GO:0006086 IMP
    acetyl-CoA biosynthetic process from pyruvate GO:0006086 ISO
    acetyl-CoA biosynthetic process from pyruvate GO:0006086 ISO
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IBA
    mitochondrial matrix GO:0005759 IDA
    pyruvate dehydrogenase complex GO:0045254 IBA
    pyruvate dehydrogenase complex GO:0045254 ISO
    acetyltransferase complex GO:1902493 ISO
 Experiment description of studies that identified Pdhx in sEVs
1
Experiment ID 1321
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 33785738    
Organism Homo sapiens
Experiment description Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs
Authors "Todkar K, Chikhi L, Desjardins V, El-Mortada F, Pépin G, Germain M. "
Journal name Nat Commun
Publication year 2021
Sample Osteosarcoma cells
Sample name U2OS
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
 Protein-protein interactions for Pdhx
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
2 Mapt  
Affinity Capture-MS Mus musculus
3 Atg16l1  
Affinity Capture-MS Mus musculus
4 HSD17B10 3028
Affinity Capture-MS Homo sapiens
5 Dld 13382
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
6 Pdhx 27402
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here