Gene description for Sptan1
Gene name spectrin alpha, non-erythrocytic 1
Gene symbol Sptan1
Other names/aliases 2610027H02Rik
Species Mus musculus
 Database cross references - Sptan1
ExoCarta ExoCarta_20740
Entrez Gene 20740
 Sptan1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Sptan1
Molecular Function
    syntaxin binding GO:0019905 ISO
    protein complex binding GO:0032403 ISO
    actin binding GO:0003779 IEA
    protein N-terminus binding GO:0047485 ISO
    spectrin binding GO:0030507 ISO
    protein binding GO:0005515 IPI
    protein heterodimerization activity GO:0046982 IDA
    calmodulin binding GO:0005516 IEA
    calcium ion binding GO:0005509 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    actin filament capping GO:0051693 IEA
    actin cytoskeleton reorganization GO:0031532 ISO
Subcellular Localization
    cortical cytoskeleton GO:0030863 IDA
    extracellular vesicle GO:1903561 ISO
    Z disc GO:0030018 IDA
    intracellular membrane-bounded organelle GO:0043231 ISO
    lateral plasma membrane GO:0016328 IDA
    extracellular exosome GO:0070062 ISO
    plasma membrane GO:0005886 ISO
    microtubule cytoskeleton GO:0015630 ISO
    paranode region of axon GO:0033270 IDA
    protein complex GO:0043234 ISO
    membrane GO:0016020 IDA
    fascia adherens GO:0005916 IDA
    cuticular plate GO:0032437 IDA
    cytoskeleton GO:0005856 IEA
    cytoplasm GO:0005737 IEA
    myelin sheath GO:0043209 IDA
 Experiment description of studies that identified Sptan1 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Sptan1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sptan1 is involved
No pathways found

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