Gene description for Phb
Gene name prohibitin
Gene symbol Phb
Other names/aliases Bap32
Species Mus musculus
 Database cross references - Phb
ExoCarta ExoCarta_18673
Entrez Gene 18673
UniProt P67778  
 Phb identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Phb
Molecular Function
    histone deacetylase binding GO:0042826 ISO
    complement component C3b binding GO:0001851 ISO
    transcription regulatory region DNA binding GO:0044212 ISO
    sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 IDA
    complement component C3a binding GO:0001850 ISO
    proteinase activated receptor binding GO:0031871 ISO
    enzyme binding GO:0019899 ISO
    protein C-terminus binding GO:0008022 ISO
Biological Process
    cellular response to interleukin-6 GO:0071354 ISO
    negative regulation of androgen receptor signaling pathway GO:0060766 ISO
    negative regulation of transcription by competitive promoter binding GO:0010944 ISO
    negative regulation of protein catabolic process GO:0042177 ISO
    negative regulation of cell proliferation GO:0008285 ISO
    positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 ISO
    negative regulation of glucocorticoid receptor signaling pathway GO:2000323 ISO
    transcription from RNA polymerase II promoter GO:0006366 IDA
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    histone deacetylation GO:0016575 ISO
    protein stabilization GO:0050821 ISO
    osteoblast differentiation GO:0001649 ISO
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    progesterone receptor signaling pathway GO:0050847 ISO
    positive regulation of complement activation GO:0045917 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    negative regulation of cell growth GO:0030308 ISO
    regulation of transcription, DNA-templated GO:0006355 ISO
    negative regulation of ERK1 and ERK2 cascade GO:0070373 ISO
    DNA biosynthetic process GO:0071897 IMP
    mitochondrion organization GO:0007005 ISO
Subcellular Localization
    plasma membrane GO:0005886 ISO
    extrinsic component of mitochondrial outer membrane GO:0031315 ISO
    mitochondrial inner membrane GO:0005743 ISO
    mitochondrion GO:0005739 ISO
    integral component of plasma membrane GO:0005887 ISO
    cytoplasm GO:0005737 ISO
    nucleoplasm GO:0005654 ISO
    myelin sheath GO:0043209 IDA
    membrane GO:0016020 ISO
    mitochondrial crista GO:0030061 ISO
    early endosome GO:0005769 ISO
    cell surface GO:0009986 ISO
    nucleus GO:0005634 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Phb in exosomes
1
Experiment ID 188
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Phb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Phb is involved
No pathways found





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