Gene description for Phb
Gene name	prohibitin
Gene symbol	Phb
Other names/aliases	Bap32
Species	Mus musculus
Database cross references - Phb
ExoCarta	ExoCarta_18673
Vesiclepedia	VP_18673
Entrez Gene	18673
UniProt	P67778
Phb identified in sEVs derived from the following tissue/cell type
Melanoma cells	34957415
Melanoma cells	34957415
Pancreatic cells	19351151

Gene ontology annotations for Phb

Molecular Function     complement component C3a binding GO:0001850 IEA     complement component C3a binding GO:0001850 ISO     complement component C3b binding GO:0001851 IEA     complement component C3b binding GO:0001851 ISO     transcription corepressor activity GO:0003714 IDA     transcription corepressor activity GO:0003714 ISO     protein binding GO:0005515 IPI     enzyme binding GO:0019899 ISO     proteinase activated receptor binding GO:0031871 IEA     proteinase activated receptor binding GO:0031871 ISO     histone deacetylase binding GO:0042826 IEA     histone deacetylase binding GO:0042826 ISO     protein heterodimerization activity GO:0046982 IEA     protein heterodimerization activity GO:0046982 ISO Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     ovarian follicle development GO:0001541 IEA     ovarian follicle atresia GO:0001552 IEA     positive regulation of immunoglobulin production GO:0002639 IDA     regulation of DNA-templated transcription GO:0006355 ISO     mitochondrion organization GO:0007005 IBA     mitochondrion organization GO:0007005 ISO     mitochondrion organization GO:0007005 NAS     negative regulation of cell population proliferation GO:0008285 IEA     negative regulation of cell population proliferation GO:0008285 ISO     response to xenobiotic stimulus GO:0009410 IEA     positive regulation of gene expression GO:0010628 ISO     negative regulation of gene expression GO:0010629 IEA     negative regulation of gene expression GO:0010629 ISO     negative regulation of transcription by competitive promoter binding GO:0010944 IEA     negative regulation of transcription by competitive promoter binding GO:0010944 ISO     negative regulation of cell growth GO:0030308 IEA     negative regulation of cell growth GO:0030308 ISO     animal organ regeneration GO:0031100 IEA     positive regulation of interleukin-17 production GO:0032740 ISO     positive regulation of interleukin-17 production GO:0032740 ISS     response to immobilization stress GO:0035902 IEA     RIG-I signaling pathway GO:0039529 IEA     RIG-I signaling pathway GO:0039529 ISO     epigenetic regulation of gene expression GO:0040029 IEA     epigenetic regulation of gene expression GO:0040029 ISO     B cell activation GO:0042113 IDA     negative regulation of protein catabolic process GO:0042177 IEA     negative regulation of protein catabolic process GO:0042177 ISO     negative regulation of apoptotic process GO:0043066 IEA     negative regulation of apoptotic process GO:0043066 ISO     response to peptide hormone GO:0043434 IEA     positive regulation of neuron apoptotic process GO:0043525 IEA     positive regulation of neuron apoptotic process GO:0043525 ISO     modulation by host of viral RNA genome replication GO:0044830 IDA     response to ethanol GO:0045471 IEA     positive regulation of G protein-coupled receptor signaling pathway GO:0045745 IEA     positive regulation of G protein-coupled receptor signaling pathway GO:0045745 ISO     negative regulation of DNA-templated transcription GO:0045892 ISO     positive regulation of DNA-templated transcription GO:0045893 IEA     positive regulation of DNA-templated transcription GO:0045893 ISO     positive regulation of complement activation GO:0045917 IEA     positive regulation of complement activation GO:0045917 ISO     symbiont entry into host cell GO:0046718 IDA     positive regulation of smooth muscle cell proliferation GO:0048661 ISO     positive regulation of smooth muscle cell proliferation GO:0048661 ISS     protein stabilization GO:0050821 ISO     progesterone receptor signaling pathway GO:0050847 IEA     progesterone receptor signaling pathway GO:0050847 ISO     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS     negative regulation of androgen receptor signaling pathway GO:0060766 IEA     negative regulation of androgen receptor signaling pathway GO:0060766 ISO     negative regulation of ERK1 and ERK2 cascade GO:0070373 IEA     negative regulation of ERK1 and ERK2 cascade GO:0070373 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     cellular response to interleukin-6 GO:0071354 IEA     cellular response to interleukin-6 GO:0071354 ISO     DNA biosynthetic process GO:0071897 IMP     T-helper 17 type immune response GO:0072538 ISO     T-helper 17 type immune response GO:0072538 ISS     antiviral innate immune response GO:0140374 IEA     antiviral innate immune response GO:0140374 ISO     positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 IDA     negative regulation of glucocorticoid receptor signaling pathway GO:2000323 IEA     negative regulation of glucocorticoid receptor signaling pathway GO:2000323 ISO Subcellular Localization     nucleus GO:0005634 IDA     nucleus GO:0005634 ISO     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 HDA     mitochondrion GO:0005739 IBA     mitochondrion GO:0005739 IDA     mitochondrion GO:0005739 ISO     mitochondrial outer membrane GO:0005741 IEA     mitochondrial outer membrane GO:0005741 ISO     mitochondrial inner membrane GO:0005743 HDA     mitochondrial inner membrane GO:0005743 IDA     mitochondrial inner membrane GO:0005743 ISO     early endosome GO:0005769 IEA     early endosome GO:0005769 ISO     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     cell surface GO:0009986 IDA     cell surface GO:0009986 ISO     cell surface GO:0009986 ISS     postsynaptic density GO:0014069 IEA     postsynaptic density GO:0014069 ISO     mitochondrial prohibitin complex GO:0035632 IPI     mitochondrial prohibitin complex GO:0035632 ISO     mitochondrial prohibitin complex GO:0035632 ISS     myelin sheath GO:0043209 HDA     synapse GO:0045202 ISO     extrinsic component of presynaptic active zone membrane GO:0098891 IEA     extrinsic component of presynaptic active zone membrane GO:0098891 ISO     glutamatergic synapse GO:0098978 IEA     glutamatergic synapse GO:0098978 ISO     GABA-ergic synapse GO:0098982 IEA     GABA-ergic synapse GO:0098982 ISO