Gene description for Phb2
Gene name	prohibitin 2
Gene symbol	Phb2
Other names/aliases	AU044498 BAP Bap37 Bcap37 REA
Species	Mus musculus
Database cross references - Phb2
ExoCarta	ExoCarta_12034
Vesiclepedia	VP_12034
Entrez Gene	12034
UniProt	O35129
Phb2 identified in sEVs derived from the following tissue/cell type
Pancreatic cells	19351151

Gene ontology annotations for Phb2

Molecular Function     protein binding GO:0005515 IPI     amide binding GO:0033218 IEA     amide binding GO:0033218 ISO     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 ISO     protein homodimerization activity GO:0042803 ISS     sphingolipid binding GO:0046625 IDA     sphingolipid binding GO:0046625 ISO     protein heterodimerization activity GO:0046982 IEA     protein heterodimerization activity GO:0046982 ISO Biological Process     mitophagy GO:0000423 IDA     mitophagy GO:0000423 ISO     positive regulation of immunoglobulin production GO:0002639 IDA     protein import into nucleus GO:0006606 IEA     protein import into nucleus GO:0006606 ISO     mitochondrion organization GO:0007005 IBA     mitochondrion organization GO:0007005 ISO     mitochondrion organization GO:0007005 NAS     sister chromatid cohesion GO:0007062 IEA     sister chromatid cohesion GO:0007062 ISO     cell migration GO:0016477 ISO     cell migration GO:0016477 ISS     estrogen receptor signaling pathway GO:0030520 IMP     positive regulation of exit from mitosis GO:0031536 IEA     positive regulation of exit from mitosis GO:0031536 ISO     negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 IGI     negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 IMP     mammary gland epithelial cell proliferation GO:0033598 IMP     negative regulation of mammary gland epithelial cell proliferation GO:0033600 IMP     RIG-I signaling pathway GO:0039529 IEA     RIG-I signaling pathway GO:0039529 ISO     B cell activation GO:0042113 IDA     negative regulation of apoptotic process GO:0043066 IEA     negative regulation of apoptotic process GO:0043066 ISO     positive regulation of MAPK cascade GO:0043410 ISS     negative regulation of DNA-binding transcription factor activity GO:0043433 ISO     negative regulation of DNA-templated transcription GO:0045892 IDA     negative regulation of DNA-templated transcription GO:0045892 ISO     protein stabilization GO:0050821 ISO     positive regulation of DNA-binding transcription factor activity GO:0051091 ISO     mammary gland branching involved in thelarche GO:0060744 IMP     mammary gland alveolus development GO:0060749 IMP     regulation of branching involved in mammary gland duct morphogenesis GO:0060762 IMP     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     cellular response to retinoic acid GO:0071300 IEA     cellular response to hypoxia GO:0071456 IEA     antiviral innate immune response GO:0140374 IEA     antiviral innate immune response GO:0140374 ISO     regulation of cardiolipin metabolic process GO:1900208 IMP     positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 IDA     positive regulation of cell cycle G1/S phase transition GO:1902808 IEA     positive regulation of cell cycle G1/S phase transition GO:1902808 ISO     regulation of cytochrome-c oxidase activity GO:1904959 IMP     regulation of cytochrome-c oxidase activity GO:1904959 ISO Subcellular Localization     nucleus GO:0005634 IDA     nucleus GO:0005634 ISO     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 HDA     mitochondrion GO:0005739 IBA     mitochondrion GO:0005739 IDA     mitochondrion GO:0005739 ISO     mitochondrial outer membrane GO:0005741 IEA     mitochondrial outer membrane GO:0005741 ISO     mitochondrial inner membrane GO:0005743 IDA     mitochondrial inner membrane GO:0005743 ISO     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     cell surface GO:0009986 IDA     cell surface GO:0009986 ISO     cell surface GO:0009986 ISS     postsynaptic density GO:0014069 IEA     postsynaptic density GO:0014069 ISO     nuclear matrix GO:0016363 ISO     nuclear matrix GO:0016363 ISS     axon GO:0030424 IEA     axon GO:0030424 ISO     protein-containing complex GO:0032991 ISO     protein-containing complex GO:0032991 ISS     mitochondrial prohibitin complex GO:0035632 IPI     mitochondrial prohibitin complex GO:0035632 ISO     mitochondrial prohibitin complex GO:0035632 ISS     presynaptic active zone GO:0048786 IEA     presynaptic active zone GO:0048786 ISO     cell periphery GO:0071944 ISO     inner mitochondrial membrane protein complex GO:0098800 IDA     glutamatergic synapse GO:0098978 IEA     glutamatergic synapse GO:0098978 ISO     GABA-ergic synapse GO:0098982 IEA     GABA-ergic synapse GO:0098982 ISO