Gene description for Phb2
Gene name prohibitin 2
Gene symbol Phb2
Other names/aliases AU044498
BAP
Bap37
Bcap37
REA
Species Mus musculus
 Database cross references - Phb2
ExoCarta ExoCarta_12034
Entrez Gene 12034
UniProt O35129  
 Phb2 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Phb2
Molecular Function
    protein binding GO:0005515 IPI
    protein C-terminus binding GO:0008022 ISO
    amide binding GO:0033218 ISO
    chromatin binding GO:0003682 ISO
    protein N-terminus binding GO:0047485 ISO
Biological Process
    positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 ISO
    negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 ISO
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    mammary gland branching involved in thelarche GO:0060744 IMP
    protein import into nucleus, translocation GO:0000060 ISO
    sister chromatid cohesion GO:0007062 ISO
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of cell cycle G1/S phase transition GO:1902808 ISO
    protein stabilization GO:0050821 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
    negative regulation of apoptotic process GO:0043066 ISO
    negative regulation of mammary gland epithelial cell proliferation GO:0033600 IMP
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    regulation of branching involved in mammary gland duct morphogenesis GO:0060762 IMP
    positive regulation of exit from mitosis GO:0031536 ISO
    mammary gland alveolus development GO:0060749 IMP
    negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 IMP
    mitochondrion organization GO:0007005 ISO
Subcellular Localization
    membrane GO:0016020 IEA
    extracellular exosome GO:0070062 ISO
    cell surface GO:0009986 ISO
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrion GO:0005739 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    nuclear matrix GO:0016363 ISO
    chromatin GO:0000785 ISO
    cell periphery GO:0071944 ISO
    protein complex GO:0043234 ISO
    mitochondrial outer membrane GO:0005741 ISO
 Experiment description of studies that identified Phb2 in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Phb2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Phb2 is involved
No pathways found





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