Gene description for Hdac1
Gene name histone deacetylase 1
Gene symbol Hdac1
Other names/aliases HD1
Hdac1-ps
MommeD5
RPD3
Species Mus musculus
 Database cross references - Hdac1
ExoCarta ExoCarta_433759
Vesiclepedia VP_433759
Entrez Gene 433759
UniProt O09106  
 Hdac1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Mast cells 17486113    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Hdac1
Molecular Function
    RNA polymerase II repressing transcription factor binding GO:0001103 ISO
    RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 ISO
    transcription regulatory region sequence-specific DNA binding GO:0000976 IDA
    histone deacetylase activity GO:0004407 ISO
    enzyme binding GO:0019899 ISO
    protein N-terminus binding GO:0047485 ISO
    protein binding GO:0005515 IPI
    Krueppel-associated box domain binding GO:0035851 IPI
    deacetylase activity GO:0019213 IDA
    DNA binding GO:0003677 IDA
    transcription corepressor activity GO:0003714 IDA
    activating transcription factor binding GO:0033613 ISO
    histone deacetylase binding GO:0042826 ISO
    transcription factor binding GO:0008134 TAS
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    histone deacetylase activity (H3-K14 specific) GO:0031078 IEA
    NAD-dependent histone deacetylase activity (H3-K18 specific) GO:0097372 IEA
    NAD-dependent histone deacetylase activity (H4-K16 specific) GO:0046970 IEA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 ISO
    core promoter binding GO:0001047 ISO
    hydrolase activity GO:0016787 IEA
    NF-kappaB binding GO:0051059 ISO
    chromatin binding GO:0003682 ISO
    RNA polymerase II transcription corepressor activity GO:0001106 ISO
    protein deacetylase activity GO:0033558 ISO
    histone deacetylase activity (H3-K9 specific) GO:0032129 IEA
    NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0032041 IEA
    transcription regulatory region DNA binding GO:0044212 ISO
    protein complex binding GO:0032403 ISO
    histone deacetylase activity (H4-K16 specific) GO:0034739 IEA
    nucleosomal DNA binding GO:0031492 ISO
    repressing transcription factor binding GO:0070491 ISO
    NAD-dependent histone deacetylase activity (H3-K9 specific) GO:0046969 IEA
Biological Process
    negative regulation of insulin secretion GO:0046676 ISO
    hair follicle placode formation GO:0060789 IGI
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    transcription from RNA polymerase II promoter GO:0006366 ISO
    embryonic digit morphogenesis GO:0042733 IGI
    protein deacetylation GO:0006476 ISO
    negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 IGI
    negative regulation of canonical Wnt signaling pathway GO:0090090 IGI
    negative regulation of androgen receptor signaling pathway GO:0060766 ISO
    positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
    histone H4 deacetylation GO:0070933 ISO
    positive regulation of cell proliferation GO:0008284 ISO
    positive regulation of receptor biosynthetic process GO:0010870 ISO
    negative regulation by host of viral transcription GO:0043922 ISO
    eyelid development in camera-type eye GO:0061029 IGI
    transcription, DNA-templated GO:0006351 IEA
    response to amphetamine GO:0001975 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    positive regulation of tumor necrosis factor production GO:0032760 ISO
    positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 ISO
    neuron differentiation GO:0030182 IGI
    negative regulation of neuron apoptotic process GO:0043524 ISO
    chromatin modification GO:0016568 TAS
    negative regulation of apoptotic process GO:0043066 IGI
    negative regulation of cell proliferation GO:0008285 ISO
    circadian rhythm GO:0007623 IDA
    cellular response to oxidative stress GO:0034599 ISO
    positive regulation of oligodendrocyte differentiation GO:0048714 ISO
    positive regulation of interleukin-1 production GO:0032732 ISO
    epidermal cell differentiation GO:0009913 IGI
    fungiform papilla formation GO:0061198 IGI
    circadian regulation of gene expression GO:0032922 IDA
    negative regulation of intrinsic apoptotic signaling pathway GO:2001243 IGI
    positive regulation of type B pancreatic cell apoptotic process GO:2000676 ISO
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    negative regulation of gene expression GO:0010629 ISO
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    histone H3 deacetylation GO:0070932 ISO
    negative regulation of peptidyl-lysine acetylation GO:2000757 ISO
    endoderm development GO:0007492 IMP
    histone deacetylation GO:0016575 ISO
    hippocampus development GO:0021766 IGI
    odontogenesis of dentin-containing tooth GO:0042475 IGI
    rhythmic process GO:0048511 IEA
    ATP-dependent chromatin remodeling GO:0043044 ISO
Subcellular Localization
    nuclear chromatin GO:0000790 ISO
    NuRD complex GO:0016581 ISO
    cytosol GO:0005829 ISO
    neuron projection GO:0043005 ISO
    transcription factor complex GO:0005667 IPI
    perinuclear region of cytoplasm GO:0048471 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 TAS
    protein complex GO:0043234 ISO
    nucleoplasm GO:0005654 ISO
    transcriptional repressor complex GO:0017053 IPI
    Sin3 complex GO:0016580 ISO
    chromatin GO:0000785 ISO
    histone deacetylase complex GO:0000118 TAS
    neuronal cell body GO:0043025 IDA
    heterochromatin GO:0000792 IDA
 Experiment description of studies that identified Hdac1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 15
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
3
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Hdac1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Myod1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
2 RELA 5970
Affinity Capture-Western Homo sapiens
3 IKZF1  
Affinity Capture-Western Homo sapiens
4 Rela  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
5 Rb1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
6 Ikzf1  
Co-fractionation Mus musculus
7 Nfkb1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
8 Sall1  
Reconstituted Complex Mus musculus
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