Gene description for Hdac1
Gene name histone deacetylase 1
Gene symbol Hdac1
Other names/aliases HD1
Hdac1-ps
MommeD5
RPD3
Species Mus musculus
 Database cross references - Hdac1
ExoCarta ExoCarta_433759
Vesiclepedia VP_433759
Entrez Gene 433759
UniProt O09106  
 Hdac1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Mast cells 17486113    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Hdac1
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO
    RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA
    RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 ISO
    core promoter sequence-specific DNA binding GO:0001046 ISO
    transcription corepressor binding GO:0001222 IEA
    transcription corepressor binding GO:0001222 ISO
    p53 binding GO:0002039 IEA
    p53 binding GO:0002039 ISO
    DNA binding GO:0003677 IDA
    chromatin binding GO:0003682 IDA
    chromatin binding GO:0003682 ISO
    transcription corepressor activity GO:0003714 IDA
    transcription corepressor activity GO:0003714 ISO
    histone deacetylase activity GO:0004407 IBA
    histone deacetylase activity GO:0004407 IDA
    histone deacetylase activity GO:0004407 ISO
    histone deacetylase activity GO:0004407 TAS
    protein binding GO:0005515 IPI
    deacetylase activity GO:0019213 ISO
    enzyme binding GO:0019899 ISO
    histone H3K14 deacetylase activity, hydrolytic mechanism GO:0031078 IEA
    histone H3K9 deacetylase activity, hydrolytic mechanism GO:0032129 IEA
    protein lysine deacetylase activity GO:0033558 ISO
    histone H4K16 deacetylase activity, hydrolytic mechanism GO:0034739 IEA
    Krueppel-associated box domain binding GO:0035851 IPI
    histone deacetylase binding GO:0042826 IEA
    histone deacetylase binding GO:0042826 ISO
    tubulin deacetylase activity GO:0042903 IEA
    protein-containing complex binding GO:0044877 ISO
    metal ion binding GO:0046872 IEA
    NF-kappaB binding GO:0051059 IEA
    NF-kappaB binding GO:0051059 ISO
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 ISO
    E-box binding GO:0070888 IDA
    DNA-binding transcription factor binding GO:0140297 IPI
    DNA-binding transcription factor binding GO:0140297 ISO
    DNA-binding transcription factor binding GO:0140297 TAS
    histone H4K12 deacetylase activity, hydrolytic mechanism GO:0140937 IEA
    histone decrotonylase activity GO:0160009 IDA
    histone decrotonylase activity GO:0160009 ISO
    protein lysine delactylase activity GO:0160216 ISS
    histone H4K5 deacetylase activity, hydrolytic mechanism GO:0180032 IEA
    histone H4K8 deacetylase activity, hydrolytic mechanism GO:0180033 IEA
    histone H3K4 deacetylase activity, hydrolytic mechanism GO:1990162 IEA
    promoter-specific chromatin binding GO:1990841 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 IGI
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    negative regulation of transcription by RNA polymerase II GO:0000122 NAS
    chromatin organization GO:0006325 TAS
    chromatin remodeling GO:0006338 ISO
    DNA methylation-dependent constitutive heterochromatin formation GO:0006346 IEA
    DNA methylation-dependent constitutive heterochromatin formation GO:0006346 ISO
    regulation of transcription by RNA polymerase II GO:0006357 ISO
    protein deacetylation GO:0006476 ISO
    endoderm development GO:0007492 IDA
    endoderm development GO:0007492 IMP
    circadian rhythm GO:0007623 IDA
    positive regulation of cell population proliferation GO:0008284 IGI
    positive regulation of cell population proliferation GO:0008284 ISO
    epidermal cell differentiation GO:0009913 IGI
    negative regulation of gene expression GO:0010629 ISO
    hippocampus development GO:0021766 IGI
    neuron differentiation GO:0030182 IGI
    negative regulation of cell migration GO:0030336 NAS
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 NAS
    heterochromatin formation GO:0031507 IBA
    circadian regulation of gene expression GO:0032922 IDA
    odontogenesis of dentin-containing tooth GO:0042475 IGI
    regulation of cell fate specification GO:0042659 NAS
    embryonic digit morphogenesis GO:0042733 IGI
    negative regulation of apoptotic process GO:0043066 IGI
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IGI
    negative regulation by host of viral transcription GO:0043922 IEA
    negative regulation by host of viral transcription GO:0043922 ISO
    negative regulation of gene expression, epigenetic GO:0045814 ISO
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 ISO
    negative regulation of DNA-templated transcription GO:0045892 NAS
    positive regulation of DNA-templated transcription GO:0045893 ISO
    positive regulation of DNA-templated transcription GO:0045893 NAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    oligodendrocyte differentiation GO:0048709 IGI
    positive regulation of oligodendrocyte differentiation GO:0048714 IGI
    negative regulation of androgen receptor signaling pathway GO:0060766 IEA
    negative regulation of androgen receptor signaling pathway GO:0060766 ISO
    hair follicle placode formation GO:0060789 IGI
    eyelid development in camera-type eye GO:0061029 IGI
    fungiform papilla formation GO:0061198 IGI
    negative regulation of canonical Wnt signaling pathway GO:0090090 IGI
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISO
    negative regulation of stem cell population maintenance GO:1902455 NAS
    positive regulation of stem cell population maintenance GO:1902459 NAS
    positive regulation of signaling receptor activity GO:2000273 ISO
    regulation of stem cell differentiation GO:2000736 NAS
    negative regulation of intrinsic apoptotic signaling pathway GO:2001243 IGI
Subcellular Localization
    histone deacetylase complex GO:0000118 IPI
    histone deacetylase complex GO:0000118 ISO
    histone deacetylase complex GO:0000118 TAS
    chromatin GO:0000785 IDA
    chromatin GO:0000785 ISO
    heterochromatin GO:0000792 IDA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 ISO
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 IDA
    transcription regulator complex GO:0005667 IPI
    cytoplasm GO:0005737 TAS
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    NuRD complex GO:0016581 IBA
    NuRD complex GO:0016581 IDA
    NuRD complex GO:0016581 IPI
    NuRD complex GO:0016581 ISO
    NuRD complex GO:0016581 NAS
    transcription repressor complex GO:0017053 IPI
    protein-containing complex GO:0032991 IDA
    protein-containing complex GO:0032991 ISO
    neuronal cell body GO:0043025 IDA
    perinuclear region of cytoplasm GO:0048471 ISO
    Sin3-type complex GO:0070822 ISO
    Sin3-type complex GO:0070822 NAS
 Experiment description of studies that identified Hdac1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
3
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Hdac1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Stat5a  
Affinity Capture-Western Mus musculus
2 Phb2 12034
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
3 Jdp2  
Affinity Capture-Western Mus musculus
4 Chd5  
Affinity Capture-Western Mus musculus
5 Pparg  
Affinity Capture-Western Mus musculus
6 Tfcp2l1  
Affinity Capture-MS Mus musculus
7 Tcf7l2  
Affinity Capture-Western Mus musculus
8 Cebpa  
Affinity Capture-MS Mus musculus
9 Cul3  
Affinity Capture-Western Mus musculus
10 Rbbp7 245688
Two-hybrid Mus musculus
11 Dzip3  
Affinity Capture-Western Mus musculus
12 Kdm5b  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
13 Ezh2  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
14 Rb1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
15 Sp3  
Affinity Capture-Western Mus musculus
16 Whsc1  
Affinity Capture-Western Mus musculus
17 Ss18 268996
Affinity Capture-Western Mus musculus
18 Atg16l1  
Affinity Capture-MS Mus musculus
19 Kif2a 16563
Affinity Capture-Western Mus musculus
20 Hdac9  
Affinity Capture-Western Mus musculus
21 Hist4h4 320332
Biochemical Activity Mus musculus
22 Ikzf1  
Co-fractionation Mus musculus
23 Msx2  
Reconstituted Complex Mus musculus
24 Ccnd1  
Affinity Capture-Western Mus musculus
25 Mta1  
Affinity Capture-Western Mus musculus
26 Smad4 17128
Affinity Capture-Western Mus musculus
27 Gata1  
Affinity Capture-Western Mus musculus
28 Satb2  
Affinity Capture-Western Mus musculus
29 Rbl2  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
30 Foxp3  
Affinity Capture-MS Mus musculus
31 Yy1 22632
Affinity Capture-Western Mus musculus
32 Runx1 12394
Affinity Capture-MS Mus musculus
33 Tfe3  
Affinity Capture-MS Mus musculus
34 Sp1 20683
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
Reconstituted Complex Mus musculus
35 Ddb1 13194
Affinity Capture-MS Mus musculus
36 E2f1  
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
37 Ccne1  
Affinity Capture-Western Mus musculus
38 Mybbp1a 18432
Affinity Capture-Western Mus musculus
39 Hdac1 433759
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
40 Ppia 268373
Affinity Capture-Western Mus musculus
41 Tle1 21885
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
42 Nanog  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
43 Gsc  
Affinity Capture-Western Mus musculus
44 Gon4l 76022
Affinity Capture-Western Mus musculus
45 Zbtb16  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
46 Sall4  
Affinity Capture-MS Mus musculus
47 REST 5978
Reconstituted Complex Homo sapiens
48 Cry1  
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
49 Klf5  
Affinity Capture-Western Mus musculus
50 Ifrd1  
Affinity Capture-Western Mus musculus
51 Smyd1 12180
Affinity Capture-Western Mus musculus
52 Mecp2  
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
53 Xpo1 103573
Affinity Capture-Western Mus musculus
54 Apex1  
Affinity Capture-Western Mus musculus
55 Myod1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
56 Zfp932  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
57 Mta2 23942
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
58 Nfkb1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
59 Tet2  
Affinity Capture-MS Mus musculus
60 Tal1  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
61 IKZF1  
Affinity Capture-Western Homo sapiens
62 Eed  
Two-hybrid Mus musculus
Affinity Capture-MS Mus musculus
63 Tet1  
Affinity Capture-MS Mus musculus
64 Fancd2  
Affinity Capture-MS Mus musculus
65 Tcf21  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
66 RELA 5970
Affinity Capture-Western Homo sapiens
67 Esrrb  
Affinity Capture-MS Mus musculus
68 Ets1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
69 Klf13  
Reconstituted Complex Mus musculus
70 PHB2 11331
Two-hybrid Homo sapiens
71 Hdac2  
Affinity Capture-Western Mus musculus
Synthetic Growth Defect Mus musculus
72 Pou5f1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
73 Sin3a  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
74 Brms1 107392
Affinity Capture-Western Mus musculus
75 Rbbp4 19646
Affinity Capture-Western Mus musculus
76 Atxn1  
Affinity Capture-MS Mus musculus
77 Cebpb  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
78 Chaf1a  
Affinity Capture-MS Mus musculus
79 Ubtf 21429
Affinity Capture-Western Mus musculus
Biochemical Activity Mus musculus
80 Bhlhe40  
Affinity Capture-Western Mus musculus
81 Sox2  
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
82 Sall1  
Reconstituted Complex Mus musculus
83 Rela  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
84 Zfpm1  
Affinity Capture-MS Mus musculus
85 Sin3b  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
86 Klf6  
Affinity Capture-Western Mus musculus
87 Zbtb7b  
Affinity Capture-MS Mus musculus
88 Mnt  
Affinity Capture-Western Mus musculus
89 Arid1a  
Affinity Capture-Western Mus musculus
90 Pdx1  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
91 Mad1l1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
92 Gfi1b  
Reconstituted Complex Mus musculus
View the network image/svg+xml
 Pathways in which Hdac1 is involved
PathwayEvidenceSource
Cell Cycle IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Chromatin modifying enzymes IEA Reactome
Chromatin organization IEA Reactome
Deactivation of the beta-catenin transactivating complex IEA Reactome
Developmental Biology IEA Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity IEA Reactome
Factors involved in megakaryocyte development and platelet production IEA Reactome
Formation of the beta-catenin:TCF transactivating complex IEA Reactome
G0 and Early G1 IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
HDACs deacetylate histones IEA Reactome
Hemostasis IEA Reactome
Intracellular signaling by second messengers IEA Reactome
Metabolism of proteins IEA Reactome
MITF-M-dependent gene expression IEA Reactome
MITF-M-regulated melanocyte development IEA Reactome
Mitotic G1 phase and G1/S transition IEA Reactome
Notch-HLH transcription pathway IEA Reactome
PIP3 activates AKT signaling IEA Reactome
Post-translational protein modification IEA Reactome
PTEN Regulation IEA Reactome
Regulation of MECP2 expression and activity IEA Reactome
Regulation of MITF-M-dependent genes involved in apoptosis IEA Reactome
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation IEA Reactome
Regulation of PTEN gene transcription IEA Reactome
Regulation of TP53 Activity IEA Reactome
Regulation of TP53 Activity through Acetylation IEA Reactome
RNA Polymerase I Promoter Clearance IEA Reactome
RNA Polymerase I Transcription IEA Reactome
RNA Polymerase I Transcription Initiation IEA Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function IEA Reactome
Signal Transduction IEA Reactome
Signaling by ALK IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by TGF-beta Receptor Complex IEA Reactome
Signaling by TGFB family members IEA Reactome
Signaling by WNT IEA Reactome
STAT3 nuclear events downstream of ALK signaling IEA Reactome
SUMO E3 ligases SUMOylate target proteins IEA Reactome
SUMOylation IEA Reactome
SUMOylation of chromatin organization proteins IEA Reactome
TCF dependent signaling in response to WNT IEA Reactome
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IEA Reactome
Transcriptional Regulation by MECP2 IEA Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional Regulation by TP53 IEA Reactome





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