Gene description for Smyd1
Gene name SET and MYND domain containing 1
Gene symbol Smyd1
Other names/aliases 4632404M21Rik
Bop
C78565
Zmynd18
Species Mus musculus
 Database cross references - Smyd1
ExoCarta ExoCarta_12180
Vesiclepedia VP_12180
Entrez Gene 12180
UniProt P97443  
 Smyd1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Smyd1
Molecular Function
    DNA binding GO:0003677 IEA
    transcription corepressor activity GO:0003714 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    histone H3K4 trimethyltransferase activity GO:0140999 IEA
Biological Process
    chromatin remodeling GO:0006338 IPI
    heart development GO:0007507 IMP
    positive regulation of myotube differentiation GO:0010831 IEA
    positive regulation of myotube differentiation GO:0010831 ISO
    methylation GO:0032259 IEA
    skeletal muscle cell differentiation GO:0035914 IMP
    positive regulation of myoblast differentiation GO:0045663 IEA
    positive regulation of myoblast differentiation GO:0045663 ISO
    negative regulation of DNA-templated transcription GO:0045892 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified Smyd1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Smyd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Leng8  
Co-fractionation Mus musculus
2 Smyd2  
Co-fractionation Mus musculus
3 Hdac1 433759
Affinity Capture-Western Mus musculus
4 Mypn  
Co-fractionation Mus musculus
5 Hdac3  
Affinity Capture-Western Mus musculus
6 Ttc33  
Co-fractionation Mus musculus
7 Xirp2  
Co-fractionation Mus musculus
8 Usp7  
Affinity Capture-MS Mus musculus
9 Hdac2  
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Smyd1 is involved
No pathways found





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