Gene description for Smyd1
Gene name SET and MYND domain containing 1
Gene symbol Smyd1
Other names/aliases 4632404M21Rik
Bop
C78565
Zmynd18
Species Mus musculus
 Database cross references - Smyd1
ExoCarta ExoCarta_12180
Entrez Gene 12180
UniProt P97443  
 Smyd1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Smyd1
Molecular Function
    methyltransferase activity GO:0008168 IEA
    metal ion binding GO:0046872 IEA
    DNA binding GO:0003677 IEA
    transferase activity GO:0016740 IEA
    histone-lysine N-methyltransferase activity GO:0018024 IEA
    protein binding GO:0005515 IPI
    transcription corepressor activity GO:0003714 IDA
Biological Process
    positive regulation of myoblast differentiation GO:0045663 ISO
    methylation GO:0032259 IEA
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    heart development GO:0007507 IMP
    skeletal muscle cell differentiation GO:0035914 IMP
    chromatin remodeling GO:0006338 IPI
    positive regulation of myotube differentiation GO:0010831 ISO
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified Smyd1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Smyd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Smyd1 is involved
No pathways found





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