Gene description for Xpo1
Gene name exportin 1, CRM1 homolog (yeast)
Gene symbol Xpo1
Other names/aliases AA420417
Crm1
Exp1
Species Mus musculus
 Database cross references - Xpo1
ExoCarta ExoCarta_103573
Vesiclepedia VP_103573
Entrez Gene 103573
UniProt Q6P5F9  
 Xpo1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Xpo1
Molecular Function
    protein binding GO:0005515 IPI
    protein transporter activity GO:0008565 IDA
    Ran GTPase binding GO:0008536 IEA
    nucleocytoplasmic transporter activity GO:0005487 ISO
    protein domain specific binding GO:0019904 ISO
    RNA binding GO:0003723 IEA
Biological Process
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    transport GO:0006810 IEA
    intracellular protein transport GO:0006886 IEA
    protein localization to nucleus GO:0034504 IMP
    protein export from nucleus GO:0006611 ISO
    regulation of centrosome duplication GO:0010824 IMP
    ribosomal large subunit export from nucleus GO:0000055 ISO
    regulation of protein export from nucleus GO:0046825 IMP
    ribosomal small subunit export from nucleus GO:0000056 ISO
    protein transport GO:0015031 IEA
    mRNA transport GO:0051028 IEA
    regulation of protein catabolic process GO:0042176 IMP
Subcellular Localization
    cell GO:0005623 IMP
    intracellular GO:0005622 IMP
    membrane GO:0016020 ISO
    nucleoplasm GO:0005654 ISO
    nuclear membrane GO:0031965 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    kinetochore GO:0000776 ISO
    annulate lamellae GO:0005642 ISO
    ribonucleoprotein complex GO:0030529 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Xpo1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Xpo1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPS6KB1 6198
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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