Gene description for Bach1
Gene name BTB and CNC homology 1
Gene symbol Bach1
Other names/aliases 6230421P05Rik
AI323795
Species Mus musculus
 Database cross references - Bach1
ExoCarta ExoCarta_12013
Entrez Gene 12013
UniProt P97302  
 Bach1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Bach1
Molecular Function
    sequence-specific DNA binding GO:0043565 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001205 IDA
    DNA binding GO:0003677 IDA
    RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 IDA
    protein binding GO:0005515 IPI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 ISO
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001206 IDA
Biological Process
    DNA repair GO:0006281 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    regulation of transcription involved in G2/M transition of mitotic cell cycle GO:0000117 ISO
    regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 ISO
    transcription from RNA polymerase II promoter GO:0006366 ISO
    regulation of transcription, DNA-templated GO:0006355 IDA
    regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083 ISO
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    cytosol GO:0005829 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Bach1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Bach1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Bach1 is involved
No pathways found





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