Gene description for Bach1
Gene name BTB and CNC homology 1
Gene symbol Bach1
Other names/aliases 6230421P05Rik
AI323795
Species Mus musculus
 Database cross references - Bach1
ExoCarta ExoCarta_12013
Vesiclepedia VP_12013
Entrez Gene 12013
UniProt P97302  
 Bach1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Bach1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 ISO
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 ISS
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA binding GO:0003677 IDA
    DNA-binding transcription factor activity GO:0003700 IDA
    protein binding GO:0005515 IPI
    ligand-activated transcription factor activity GO:0098531 IEA
    ligand-activated transcription factor activity GO:0098531 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    DNA repair GO:0006281 IEA
    DNA repair GO:0006281 ISO
    regulation of DNA-templated transcription GO:0006355 IDA
    regulation of DNA-templated transcription GO:0006355 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    RNA polymerase II transcription regulator complex GO:0090575 IEA
    RNA polymerase II transcription regulator complex GO:0090575 ISO
 Experiment description of studies that identified Bach1 in exosomes
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Bach1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRDX4 10549
Affinity Capture-MS Homo sapiens
2 MAFK 7975
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 KIF1B 23095
Affinity Capture-MS Homo sapiens
4 MAFF 23764
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 DPP9 91039
Affinity Capture-MS Homo sapiens
6 SYNM 23336
Affinity Capture-MS Homo sapiens
7 CCDC174  
Affinity Capture-MS Homo sapiens
8 BACH1 571
Affinity Capture-MS Homo sapiens
9 TTC3 7267
Affinity Capture-MS Homo sapiens
10 ELP3 55140
Affinity Capture-MS Homo sapiens
11 ARF3 377
Affinity Capture-MS Homo sapiens
12 Tfe3  
Affinity Capture-MS Mus musculus
13 MAFG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 SLC12A2 6558
Affinity Capture-MS Homo sapiens
15 Bach1 12013
Two-hybrid Mus musculus
Two-hybrid Mus musculus
16 Xpo1 103573
Reconstituted Complex Mus musculus
17 HMMR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 MAGT1 84061
Affinity Capture-MS Homo sapiens
19 FAM134C 162427
Affinity Capture-MS Homo sapiens
20 Smad9  
Affinity Capture-MS Mus musculus
21 ARF1 375
Affinity Capture-MS Homo sapiens
22 FAM83D 81610
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 MRPL3  
Affinity Capture-MS Homo sapiens
24 HEXB 3074
Affinity Capture-MS Homo sapiens
25 Smad1  
Affinity Capture-MS Mus musculus
26 DYNLL1 8655
Affinity Capture-MS Homo sapiens
27 Smad5  
Affinity Capture-MS Mus musculus
28 ERICH3 127254
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here