Gene description for MAFK
Gene name v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
Gene symbol MAFK
Other names/aliases NFE2U
P18
Species Homo sapiens
 Database cross references - MAFK
ExoCarta ExoCarta_7975
Entrez Gene 7975
HGNC 6782
MIM 600197
UniProt O60675  
 MAFK identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MAFK
Molecular Function
    transcription regulatory region sequence-specific DNA binding GO:0000976 IEA
    transcription cofactor binding GO:0001221 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
Biological Process
    regulation of transcription, DNA-templated GO:0006355 IEA
    transcription, DNA-templated GO:0006351 IEA
    nervous system development GO:0007399 IEA
    blood coagulation GO:0007596 TAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified MAFK in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MAFK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NFE2L2 4780
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
2 NFE2L3 9603
Two-hybrid Homo sapiens
3 MARS 4141
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which MAFK is involved
PathwayEvidenceSource
Factors involved in megakaryocyte development and platelet production TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here