Gene description for BACH2
Gene name BTB and CNC homology 1, basic leucine zipper transcription factor 2
Gene symbol BACH2
Other names/aliases BTBD25
Species Homo sapiens
 Database cross references - BACH2
ExoCarta ExoCarta_60468
Entrez Gene 60468
HGNC 14078
MIM 605394
UniProt Q9BYV9  
 BACH2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for BACH2
Molecular Function
    RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 IEA
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001206 IEA
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified BACH2 in exosomes
1
Experiment ID 234
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for BACH2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF278  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which BACH2 is involved
No pathways found





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