Gene description for BACH2
Gene name BTB and CNC homology 1, basic leucine zipper transcription factor 2
Gene symbol BACH2
Other names/aliases BTBD25
Species Homo sapiens
 Database cross references - BACH2
ExoCarta ExoCarta_60468
Vesiclepedia VP_60468
Entrez Gene 60468
HGNC 14078
MIM 605394
UniProt Q9BYV9  
 BACH2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for BACH2
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IEA
    protein binding GO:0005515 IPI
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 NAS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of transcription by RNA polymerase II GO:0006357 NAS
    import into nucleus GO:0051170 ISS
    primary adaptive immune response involving T cells and B cells GO:0090721 IMP
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    RNA polymerase II transcription regulator complex GO:0090575 IPI
    RNA polymerase II transcription regulator complex GO:0090575 ISS
 Experiment description of studies that identified BACH2 in exosomes
1
Experiment ID 234
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for BACH2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KLHL9 55958
Affinity Capture-MS Homo sapiens
2 ZNF792 126375
Two-hybrid Homo sapiens
3 SOX7  
Proximity Label-MS Homo sapiens
4 ZBTB34 403341
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
5 BAHD1  
Two-hybrid Homo sapiens
6 ACOX3 8310
Affinity Capture-MS Homo sapiens
7 MAFK 7975
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
8 LUZP4  
Two-hybrid Homo sapiens
9 ZBTB17  
Affinity Capture-MS Homo sapiens
10 MAFF 23764
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
FRET Homo sapiens
11 FAM196A  
Two-hybrid Homo sapiens
12 CCDC88A 55704
Affinity Capture-MS Homo sapiens
13 MCRS1  
Two-hybrid Homo sapiens
14 ZBTB7C  
Affinity Capture-MS Homo sapiens
15 ZNF438  
Two-hybrid Homo sapiens
16 CCDC185  
Two-hybrid Homo sapiens
17 KLHL25  
Affinity Capture-MS Homo sapiens
18 NFE2L1  
FRET Homo sapiens
19 CSNK1E 1454
Affinity Capture-MS Homo sapiens
20 ANKRD55  
Two-hybrid Homo sapiens
21 SLC43A1 8501
Two-hybrid Homo sapiens
22 ZBTB24  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
23 SCNM1  
Two-hybrid Homo sapiens
24 TSHZ2  
Two-hybrid Homo sapiens
25 FARS2 10667
Two-hybrid Homo sapiens
26 KLHL21 9903
Affinity Capture-MS Homo sapiens
27 HMG20A  
Two-hybrid Homo sapiens
28 CUL3 8452
Affinity Capture-MS Homo sapiens
29 CENPP  
Two-hybrid Homo sapiens
30 BATF3  
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
31 RPL9 6133
Two-hybrid Homo sapiens
32 CYTH1 9267
Affinity Capture-MS Homo sapiens
33 HOOK3 84376
Proximity Label-MS Homo sapiens
34 MAFG  
FRET Homo sapiens
FRET Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
35 MTA2 9219
Affinity Capture-MS Homo sapiens
36 ZNF774  
Two-hybrid Homo sapiens
37 NAT6  
Affinity Capture-MS Homo sapiens
38 ZNF124  
Two-hybrid Homo sapiens
39 TCEA2  
Two-hybrid Homo sapiens
40 FOSL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 TRIM42  
Two-hybrid Homo sapiens
42 CREB5 9586
Affinity Capture-MS Homo sapiens
43 NXF1 10482
Two-hybrid Homo sapiens
44 BACH1 571
Affinity Capture-MS Homo sapiens
45 CWF19L2  
Two-hybrid Homo sapiens
46 ATF2  
Affinity Capture-MS Homo sapiens
47 JUN 3725
Affinity Capture-MS Homo sapiens
48 DDIT3 1649
FRET Homo sapiens
49 ATF7  
Affinity Capture-MS Homo sapiens
50 HDAC3 8841
Affinity Capture-MS Homo sapiens
51 NCOR1  
Affinity Capture-MS Homo sapiens
52 RPP25  
Two-hybrid Homo sapiens
53 SULF2 55959
Affinity Capture-MS Homo sapiens
54 SP110  
Affinity Capture-MS Homo sapiens
55 NIN 51199
Proximity Label-MS Homo sapiens
56 ARRB1 408
Affinity Capture-MS Homo sapiens
57 FAM161A  
Two-hybrid Homo sapiens
58 KLHL24  
Affinity Capture-MS Homo sapiens
59 CBX8 57332
Two-hybrid Homo sapiens
60 COPS6 10980
Affinity Capture-MS Homo sapiens
61 MLX  
Two-hybrid Homo sapiens
62 ZNF131  
Affinity Capture-MS Homo sapiens
63 KAT5  
Two-hybrid Homo sapiens
64 ZBTB45  
Affinity Capture-MS Homo sapiens
65 CFAP58 159686
Two-hybrid Homo sapiens
66 MAEA 10296
Affinity Capture-MS Homo sapiens
67 BCL6  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
68 NCOR2  
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
69 PATZ1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
70 ENPP7 339221
Two-hybrid Homo sapiens
71 FUS 2521
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
72 PLD1 5337
Affinity Capture-MS Homo sapiens
73 NFE2L3 9603
FRET Homo sapiens
74 IPP  
Affinity Capture-MS Homo sapiens
75 CTSZ 1522
Two-hybrid Homo sapiens
76 SMYD1  
Two-hybrid Homo sapiens
77 TUT1  
Affinity Capture-MS Homo sapiens
78 ENC1  
Affinity Capture-MS Homo sapiens
79 TULP3 7289
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 MAFB  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BACH2 is involved
No pathways found





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